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G Biron

Publications and source records attributed to G Biron.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Cutaneous delayed hypersensitivity in a French reference population using the cell-mediated immunity multitest device].

The authors present a disposable device which may be used for skin tests studying delayed cellular hypersensitivity with 7 antigens and a glycerin control. With the aim of more objective evaluation of the results, they suggest the establishment of a score taking into account the number of positive reactions and the degree of the reactions. Finally, they describe the results of a large multicentre study involving 830 subjects considered to be healthy and divided into 4 groups according to the response to the tests.

Adolescent↗
PubMed1980

Intradermal immunization with rabies vaccine. Inactivated Wistar strain cultivated in human diploid cells.

We report a comparative study of the Mérieux Institute's inactivated rabies vaccine administered intradermally or subcutaneously. Vaccine safety was satisfactory, with only minor local and generalized reactions. Serological effectiveness was outstanding: all of those who had been seronegative became seropositive following either two intradermal or subcutaneous injections given one month apart. A comparison of the intradermal and subcutaneous routes demonstrated several important points. Antibody titers developing after subcutaneous immunization were greater than after intradermal immunization. The kinetics of antibody development during primary immunization were parallel in the two immunization protocols. Eleven months after primary immunization, subcutaneous administration of a booster dose of vaccine resulted in a titer elevation 1.86-fold greater than that in intradermal administration. Each of these levels indicated good serological response.

Adult↗
PubMed1980

[Multipuncture: a simple test for cell immunity at the patient's bedside. Determination of a reference population (author's transl)].

Two-hundred and fifty-four hospital patients (125 men and 129 women) treated for neurological or osteo-articular disorders, free from severe underlying diseases, non-atopic and not receiving immunosuppressants were tested for cutaneous delayed hypersensitivity with a multipuncture instrument which measures the response to 7 antigens simultaneously. The purpose of the trial was to determine normal control values in an immunologically normal population. The antigens used were tuberculin, tetanus and diphtheria anatoxins, Candida, Proteus, Streptococcus and Trichophyton. All tests were carried out by the same operator. The subjects were divided into 8 groups according to their sex and age (15-24, 25-39, 40-64 and 65 years or more) and statistical assessment of the results was based on the number and diameter of skin reactions and on individual scores, each score being the sum of mean diameters of all positive reactions observed at 24 and 48 hours. The overall incidence of positive responses was superior to 50%, except for Trichophyton in men and anatoxins in women. Responses were less pronounced in women of all ages than in men, and the number of positive skin tests, as well as the score values, were reduced in subjects aged 65 or more, particularly in males. The population thus tested could serve as reference in further studies using multipuncture.

Adult↗
PubMed1978

Combination of attenuated measles vaccine (Schwarz) with meningococcus A and A + C vaccine.

There is an obvious interest in a combined meningococcus-measles vaccine since the two diseases are widespread and serious in Third World countries among children under five years of age. The purpose of our study was to show the safety and effectiveness of such a combined preparation. The study covered 110 children between 8 months and 4 years of age who were followed systematically in a maternal child health center in the Paris area. Only 93 of them were checked before and after the immunization. The serologic titrations by the hemagglutination assay (IHA) for measles, and by radioimmunological assay (RIA) for meningococcus A and C showed that the Schwarz strain measles vaccine combined with meningococcus A or the association A+C does not interfere with the increase of A or C titers. 100% of the children showed a seroconversion equal to or less than 2 micrograms per ml, in the case of meningococcus A, as well as for C, regardless of age. Furthermore, 88% of the subjects showed a titer greater than or equal to 4 micrograms for the meningococcus A and 79% for C. On the other hand, meningococcus A or the association A+C seem to depress measles vaccine activity. Nevertheless, more than 80% of the children tested showed seroconversion when the measles vaccine was combined with meningococcus A, and only 69% when combined with meningococcus A and C.

Age Factors↗
PubMed1978

[Results of preventive rabies vaccination with a concentrated vaccine of the PM/WI38-1503-3M rabies strain cultured on human diploid cells. Preparation of mixed antirabies-antitetanus hyperimmune immunoglobulin by plasmapheresis of blood taken from vaccinated veterinary students].

Many thousands of people in France and abroad have already benefited from preventive rabies vaccination by means of a vaccine obtained from culture on human diploid cells, perfected ten years ago by R. Lang, the Institut Mérieux and the Wistar Institute. In addition to being well tolerated, the serological efficacy of this vaccine is such that 100% of the vaccines observed had a seroconversion after only two injections at an interval of one month. However, a booster dose should be given 6 to 12 months after the first injection, and a further booster 3 to 5 years later or on request in case of known contamination. These boosters, combined with an anti-tetanus booster, induce such high antibody titers--between 10-100 and even 1000 I.U./ml--that it is easy to obtain substantial batches of combined anti-rabies and anti-tetanus immunoglobulin from a small number of volunteers. The complete efficacy of this new vaccine reduces the number of systematic post-vaccinal serologic controls and its innocuity is such that an extended preventive vaccination programme may be carried out, for instance in the case of children living in areas known to be dangerous.

Adult↗
PubMed1977

Endodontic classification.

Clinical and histopathologic findings are mixed in current endodontic classifications. A new system, based on symptomatology, may be more useful in clincial practice. The classifications are vital asymptomatic, hypersensitive dentin, inflamed-reversible, inflamed/dengenerating without area-irreversible, inflamed/degenerating with area-irreversible, necrotic without area, and necrotic with area.

Acute Disease↗