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Biomedical subjects

G Bianchi

Publications and source records attributed to G Bianchi.

At least 469 records · Page 26Linked to original sources
PubMed1981

Familial aggregation of cation transport abnormalities and essential hypertension.

The maximal rate of activity of Na extrusion by the Na pump, Na-K outward cotransport, Na-Li countertransport and the rate constant for passive permeability to Na, K and Li were measured in the RBC of 24 normotensive subjects with both parents normotensive, 45 hypertensive subjects and 24 of their normotensive offspring. The Na extrusion by the Na pump and the passive permeability to Na, K and Li are equal. The hypertensives have significantly greater Na-Li countertransport and smaller Na-K cotransport when compared to the normotensives. Na-K cotransport and Na-Li countertransport are positively correlated, thus suggesting some relationship between the two systems. When arbitrary normal limits are set the hypertensives are divided in three groups: normal cotransport and countertransport (22.2%) high countertransport (31.1%) and low cotransport (44.4%). In nine hypertensive families studied if either alteration was observed in a hypertensive propositus, this was of the same kind as the one in case observed in any first degree relative, whether already hypertensive or young normotensive. The observed alterations are primitive to the development of hypertension and possibly related to its pathogenesis.

Adolescent↗
PubMed1981

Safety and efficacy of feprazone for long-term treatment of rheumatoid arthritis and osteoarthritis.

Long-term safety and efficacy of feprazone (4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione), an antirheumatic drug that is well tolerated in the gastrointestinal tract, were assessed in a noncontrolled multicenter trial. Administered at a daily dosage of 600 mg for a mean duration of 114.1 days, feprazone was well tolerated by 43 (77%) of 56 treated subjects. Thirteen patients reported side effects, but only five discontinued treatment. The side effects were generally mild and occurred in the first weeks of therapy. Feprazone was found effective after one month on both considered indices of disease activity: Ritchie index (articular index for assessment of joint tenderness) and corticosteroid consumption.

Arthritis, Rheumatoid↗
PubMed1980

Enzyme dissolution of a phytobezoar in a gastrectomized subject.

A case of phytobezoar in a gastrectomized patient with liver disorders is reported. Owing to the difficulty of establishing the diagnosis, the need for gastroscopy and biopsy is emphasized. Apart from the cases in which surgical removal is urgent, attention is drawn to the effectiveness of enzyme dissolution in connection with the experience described.

Bezoars↗
PubMed1980

Molding catheterism in the treatment of TB ureter stenoses: a ten-year experiment.

The authors describe their experience with molding catheterism for the treatment of TB ureter stenoses, both primitive and secondary after using chemotherapy. 85% of the cases treated with this method proved to be successful, which led the authors to recommend it prior to proceeding to any surgical treatment.

Antitubercular Agents↗
PubMed1980

[Corneoscleral melanosarcoma. Keratoplasty].

In cases of corneoscleral melanosarcoma enucleation is generally ineritable. In the case described, the patient was treated with a corneoscleral lamellar graft after excision of the enormous tumor and of a recidive. Uneventful recovery and good anatomical and functional result in the six months since the last operation.

Cornea↗
PubMed1979

Morphine no longer blocks gastrointestinal transit but retains antinociceptive action in diallylnormorphine-pretreated rats.

Diallylnormorphine (DANM) the quaternary N-allyl derivative of nalorphine, administered to rats, 8 mg/kg i.p., 20 min before i.v. injection of the potent opiate buprenorphine (1 microgram/kg, tritrium-labeled), reduced in vivo binding of the latter (63% of controls at 30 min) in small intestine longitudinal muscle including myenteric plexus, but not in cerebrum. Naloxone, 1 mg/kg s.c., had the same effect of buprenorphine binding in the two sites (52 and 54% of controls respectively). The marked slowing in the transit of a forced charcoal meal through the small intestine of rats given 10 mg/kg morphine, i.v. was prevented to comparable extents by DANM and naloxone; the latter also abolished the delay in hot plate reaction induced in these animals by morphine which, however, retained considerable antinociceptive effect in DANM-pretreated rats.

Analgesics↗
PubMed1979

[Surgical treatment in peripheral acute obliterating arterial diseases].

Vascular surgery of acute cases, embolism and thromboses encountered since 1973 in the Surgical division of Manerbio (BS) hospital is reviewed and reference made to the surgical treatment and results in 78 cases of direct vascular surgery in 68 acute patients. Following schematic presentation of the type of pathology observed and of the types of operation performed, stress is laid on the effectiveness of Vollmar rings in association with traditional Fogarty catheters in thrombectomy operations. The frequent need to associate by-pass or disobliteration of the acutely occluded segment with thrombectomy in acute thrombosis is also pointed out. The varied series involves most acute vascular pathology, inluding sapheno-femoral anastomosis, and the very low mortality and small number of amputations support surgical indications and the techniques employed.

Acute Disease↗
PubMed1979

A renal abnormality as a possible cause of "essential" hypertension.

The renal abnormality which causes hypertension in the Milan hypertensive strain of rats disappears as hypertension develops. Because of the many analogies between the condition in these rats and "essential" hypertension in man, the same pattern of change may occur if a renal abnormality is the cause of essential hypertension in man. This hypothesis was tested in two groups of young normotensive subjects matched for age, sex, and body-surface area; in the first group both parents were hypertensive, and in the second group both parents were normotensive. Renal plasma-flow, glomerular filtration-rate, plasma-volume, plasma-renin activity, plasma-concentrations of Na+, K+, and catecholamines, 24 h urinary excretion of Na+, K+, and aldosterone, and the cardiac index were measured so that renal function and the role of factors affecting blood-pressure regulation could be assessed. Renal plasma-flow was significantly higher (p less than 0.01) in the first group, whereas results of tests for all the other factors were almost the same in both groups. The hypothesis that a primary kidney abnormality causes hypertension in a proportion of patients with essential hypertension is proposed.

Adult↗