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Biomedical subjects

G Bhat

Publications and source records attributed to G Bhat.

47 records · Page 3Linked to original sources
PubMed1983

Influence of prolactin on mitotic activity of the bursa of Fabricius of the chick.

The effect of ovine prolactin (NIH-LTH) in different does (1.5, 5.0, 10.0 IU) on the mitotic activity of the bursa of Fabricius of the chick was studied. Prolactin at all doses increased the mitotic activity, but the lowest dosage (1.5 IU) was most effective). Also, prolactin, at all doses, inhibited histologically bursal secretory activity. Thus, dual action of prolactin on bursal activity in chicks is indicated.

Animals↗
PubMed1982

Thyroid gland responses to intermale aggression in an inherently aggressive wild rat.

The aim of the present investigation was to ascertain whether intermale aggression (by fighting) affects thyroid gland activity in wild rat. Following intermale aggression for three hours, thyro-follicular epithelial height was significantly decreased and colloidal content in follicular lumen increased only in the subordinate rats whereas the thyroid gland of the dominant rats was not perceptibly changed. Thus, aggression inhibits thyroid gland activity only in the subordinate rats. It is suggested that this effect may be due to psychosomatic rather than physical stress during aggression.

Aggression↗
PubMedDate not supplied

Evaluation of a patient with left ventricular assist device dysfunction.

With the increasing number of LVAD recipients due to lack of donor availability and use of an LVAD as destination therapy, there will be a significant proportion of this population presenting with device related complications. Initial evaluation should be with TEE because conduit obstruction would be a significant complication, among others. As observed in this case report, it is sometimes difficult to noninvasively detect device malfunction, and even surgical exploration left questions unanswered. Echocardiography has been the principal modality used so far to assess the LVAD cannulas. More reliance on Doppler velocities and establishment of a normal range of values and flow profiles of the inflow and outflow cannulas are necessary. Baseline echocardiographic studies could be used for future comparisons. Fluoroscopy and selective angiography have also been reported to be helpful. We would also recommend measuring LV hemodynamics, which have not been previously described, as an additional mode of evaluation of this emerging problem. This case report demonstrates the need for additional noninvasive modalities for diagnosis of ventricular assist device malfunction.

Adolescent↗
PubMedDate not supplied

The role of hearing aids in providing environmental feedback for the profoundly hearing impaired.

A number of studies have brought out the limitations of hearing aids in the rehabilitation of hearing impaired. This study was undertaken to assess the use of hearing aids in improving the ability of the hearing impaired to hear vehicular horns. The students of a school for the hearing impaired were interviewed with the help of their teachers. Out of total 102 study subjects, 47 (46%) said that they drove vehicles. None of them used hearing aid while driving vehicles. However, 56 (55%) students possessed functional box type hearing aids. Their ability to hear the sound of vehicular horns with and without hearing aids in the presence of background noise under experimental set up was assessed. None of the 36 study subjects could hear the horns (< 85 dB and > 85 dB) without hearing aid. Only 5 (16.6%) of the 30 profoundly hearing impaired students could hear the sound of horns (> 85 dB) with the hearing aid. The hearing aid was found to be more beneficial to subjects with severe hearing impairment. There is a need to bring forth newer and better varieties of hearing aids and other technologies e.g. Cochlear implant within the reach of those in need.

Accidents, Traffic↗
PubMedDate not supplied

Pretransplantation risk factors for acute rejection after heart transplantation: a multiinstitutional study. The Transplant Cardiologists Research Database Group.

To better understand the phenomenon of acute rejection in the current era of heart transplantation, complete rejection data (918 rejection episodes) from 25 institutions were analyzed for all 911 patients undergoing primary heart transplantation between January 1, 1990, and July 1, 1991. During a mean follow-up of 8.1 months (maximum, 18 months), 54% of the patients had one or more rejection episodes. The mean cumulative number of rejection episodes per patient was 0.8 at 3 months, 1.10 at 6 months, and 1.3 at 12 months after transplantation. By univariate analysis, female donor hearts (irrespective of recipient sex) (p < 0.01) and the use of induction therapy (p < 0.01) were associated with greater cumulative rejection frequency. By multivariate analysis, younger donor age and female donor gender were risk factors for earlier rejection. Solution of the multivariate equation predicted an 85% probability of rejection at 1 month for a 5-year-old female with a female donor and 50% for a 50-year-old man with a male donor. Inferences: (1) In the current era, over 40% of patients appear to be free of rejection during the first year after transplantation. (2) Younger recipient age and female donors are associated with earlier onset of allograft rejection, but the precise immunologic basis for these observations remains unknown. (3) In this experience, induction therapy did not delay the onset of first rejection nor did it reduce the cumulative number of rejection episodes. Further studies are indicated to examine the need for induction therapy.

Actuarial Analysis↗