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Biomedical subjects

G Bettega

Publications and source records attributed to G Bettega.

At least 19 recordsLinked to original sources

[Nasopalatine canal cyst: 4 cases and a review of the literature].

OBJECTIVES: Nasopalatine cyst (NPC) is the most common epithelial and non-odontogenic cyst arising in the maxilla. It is nevertheless generally underestimated by ENT surgeons. The purpose of our report was to provide details about the pathophysiology, diagnosis and treatment of NPC. MATERIAL AND METHODS: Our study was based on a retrospective analysis of four cases and a review of the literature. RESULTS: From January 2002 to March 2003, four patients (3 males and 1 female, mean age 43 Years) were treated for NPC at the ENT Department of Grenoble University hospital. One patient had received prior treatment. Symptoms were a palatine mass on the midline of the hard palate behind the central maxillary incisors in two patients, and a superior vestibular mass in the two others. Diagnosis was established on the basis of the CT-scan and histological findings. Excision was performed under general anesthesia in all four patients. Median hospital stay was four days (3-5 days). There was no post-operative complication. Median follow-up was 10 Months. CONCLUSION: NPC is arises from embryological tIssue. It must be differentiated from radicular cyst. Diagnosis is based on radiographic and histological results. Treatment consists in enucleation. Surgical access depends on the size of the cyst and its anterior or posterior extension. Excision must be total to avoid relapse which may occur after five Years. Long-term follow-up is essential.

Adult↗

Nasopalatine duct cyst (NPDc): one case report.

OBJECTIVES: NPDc arises from embryological tissue. It is classified among the epithelial non-odontogenic cysts according to the 1992 WHO histological typing of odontogenic tumors. The purpose of our report was to provide details about the pathophysiology, diagnosis and treatment of NPDc. CASE REPORT: A 25 year-old male was referred by his practitioner regarding to an intermittent palatal swelling for 6 months. Diagnosis of NPDc was suggested on the basis of computed tomography (CT-scan). Excision was performed under general anaesthesia. There was no post-operative complication. Histological features confirmed an inflamed NPDc. Follow up was 22 months, without relapse. CONCLUSION: NPDc occurs in approximately 1% of the population and forms approximately 12% of all jaw cyst tumors. NPDc may occur at any age, but main cases are seen between 40 and 60 years old. It has a slight male predilection. Black and white people are equally involved. NPDc is normally asymptomatic, unless it is infected. The most common symptom is swelling, usually in the anterior part of palate's midline. Diagnosis is based on radiographic and histological results. Treatment of choice is enucleation.

Adult↗

[Results of an evaluation of clinical practice in orthognathic surgery in France in 2002].

BACKGROUND: Over the years, orthognathic surgery has become a mainstay of maxillofacial surgery and is the object of many publications and oral communications. However, in spite of well-established methodology, disparities still exist in France basically concerning the way orthognathic surgery is performed. MATERIALS AND METHODS: In relation with the XXXIXth congress of Stomatology and Maxillofacial surgery, a questionnaire was mailed to 100 French maxillofacial surgeons. Questions dealing with some practical points of orthognathic surgery (condylar positioning, osteosynthesis technique, rate of condylar resorption.) were asked. RESULTS: Overall reply rate was 37%. Condylar positioning was performed empirically in 73% of the cases. Mandibular osteosynthesis was achieved by titanium miniplates alone in 70%. Post-operative condylar resorption rate was about 2%. This survey produced numerous astute comments. DISCUSSION: This survey highlighted the interest of maxillofacial surgeons for practical aspects of orthognathic surgery including the questions of condylar positioning or osteosynthesis technique. These points are instrumental in achieving high-quality surgical result.

Bone Plates↗

[Alveolar and hard palate repair by tibial periosteal graft in complete unilateral cleft lip and palate. Long-term follow-up of 51 cases].

PURPOSE OF THE STUDY: The purpose of this study was double: appreciate the osteogenic and growth capacities of the free tibial periosteal graft concerning the alveolar and hard palate repair in the complete unilateral cleft lip and palate, and evaluate long-term follow-up concerning maxillo-mandibular morphology and palatal air-tight. MATERIAL AND METHOD: This retrospective study concerns 51 patients, of more than 13 years of age, treated for complete unilateral cleft lip and palate. The treatment included a Skoog type cheiloplasty, a tibial periosteal graft between 4 and 6 months (as described by M. Stricker) and a staphyloraphy between 8 and 18 months. Our documentation was: figures, pictures and precise description of the initial cleft, dental casts, teleradiographies, dental panorams performed at different stages of treatment, orthodontic, orthophonic and otologic follow-up. Growth was evaluated using casts during the first 6 years then by profil teleradiographies after puberty. Ossification was evaluated quantitatively by CT scan in 18 patients. RESULTS: Results confirm an ossification of the periosteal graft in 72% of cases and the advantage of periosteal graft in palatal air-tight. 85% of cases show equilibrated squeletal growth with good occlusion, and 13.7% of cases needed deferral osteotomy. CONCLUSION: We propose a method for long-term cleft results evaluation, with the use of periosteal graft.

Adolescent↗

[Tools available for the diagnosis of obstructive sleep apnea syndrome. Measurements for the evaluation of therapeutic efficacy].

Obstructive sleep apnea syndrome (OSAS) is characterized by the development of repeated episodes of pharyngeal collapse. Respiratory movements attempt to reopen the closed pharynx leading to resumption of ventilation associated with micro-arousals. Three kinds of measurements are needed to establish the diagnosis of OSAS: airflow (reduction or complete interruption), respiratory effort in response to increased airway resistance, micro-arousals associated with the end of the respiratory event. Classically, polysomnography was used to establish sleep architecture using electroencephalography, electromyography and electro-oculography. Air flow was measured by thermistors, chest and abdominal movements and oximetry were monitored. Other more accessible methods can also be used to establish reliable diagnosis. Measuring pulse transit time using ECG and oximeter sensors provide a semi-quantitative measurement of respiratory effort. Likewise, cardiovascular markers (heart rate, blood pressure, pulse time) can be used instead of electroencephalography to establish the arousal pattern. Cardiovascular markers are as sensitive and probably as specific as EEG for identifying micro-arousals. Measuring nasal pressure provides a much less invasive quantitative assessment of airflow than pneumotachography. The shape of the inspiratory signal is also an indirect marker of respiratory effort. These new tools can be used to characterize the three elementary abnormalities observed in OSAS: variations in airflow, increased respiratory effort, fragmented sleep, using a very simplified setting compared with classical techniques. Therapeutic monitoring of OSAS patients, particularly after surgery, should not be limited to physical examination known to lack sufficient sensitivity. It should also include simplified methods or complete polysomnography to obtain a precise measurement of residual respiratory events and sleep pattern after treatment.

Air Pressure↗

[Surgery and obstructive sleep apnea syndrome: indications and precautions].

Surgery has long been a therapeutic option for obstructive sleep apnea syndrome (OSAS). The first procedures targeted the soft palate but results of isolated uvulo-palatopharyngoplasty (UPPP) were inconstant. A better understanding of the mechanisms involved in pharyngeal collapse incited interest in the role of the tongue and the retropharyngeal space. Surgical procedures were then developed for this level of the upper airways. There are a large number of possibilities. Excepting tracheostomy which court-circuits the collapsed zone, all the other procedures are designed to widen more or less one or more of the upper airway levels. The target can be the nose, the soft palate or the tongue, alone or in combinations. In all cases, the surgical alternative should be balanced against a non-invasive option: continuous positive pressure ventilation. The objective is to minimize the operative risks and sequelae while assuring success equivalent to positive pressure ventilation. It is important to note that sufficiently effective and permanent results have not been proven for any surgical technique, excepting tracheostomy and to a lesser degree bimaxillary advancement osteotomy, due to the lack of objective long-term rigorous evaluation. A considerable effort must be made in this domain.

Humans↗

[Mandibular growth, its environmental interactions].

A thorough knowledge of mandibular growth is necessary for proper comprehension of growth disorders and malformations affecting the lateral cranio-facial region. The growth mechanisms are complex and multifactorial, the mandible itself is subdivided into two heterogeneous and interdependent segments, as far as growth is concerned. These are the ramus and the corpus. The ramus is interacting with the middle cranial base through the TMJ and the temporo-pterygoid muscle belt. The mandibular body is interacting with the maxilla and the anterior cranial base. Its occlusal role is a function of the adaptive capacity of the alveolodental region.

Alveolar Process↗

[Morphological alterations of oto-mandibular syndromes].

Otomandibular dysplasia is a congenital malformation defined by a certain degree of temporomandibular or pterygomandibular hypoplasia. The syndrome is characterised by the variability of clinical findings, but the three major features are auricular, mandibular and maxillary hypoplasia. All the laterofacial structures may be affected. The deformity is usually unilateral but bilateral cases exist; a lot of associated malformations have been described. Multiple classification systems have been published. Some of them are very complex, but it is possible to define a simple diagnostic diagram based on ethiopathogenic data. Bilateral involvement affects predominantly the zygoma, and concerns hereditary syndromes. When the mandibular hypoplasia is evident Franceschetti or Goldenhar syndrome is suspected; otherwise Treacher-Collins syndrome is probable. Unilateral cases are not, in general, hereditary and the hypoplasia predominates on the mandible. The difference between hemifacial microsomia or mandibular dysplasia is made by the presence of associated laterofacial deformities.

Ear, External↗

Sleep apnoea and Turner's syndrome.

A 32-yr-old female with Turner's syndrome and anatomical craniofacial abnormalities, presented with obstructive sleep apnoea syndrome. This was initially treated by nasal continuous positive airway pressure and secondarily cured by maxillomandibullar advancement osteotomy. Anatomical upper airway abnormalities and hormonal factors, which predispose Turner patients to develop obstructive sleep apnoea syndrome, are discussed. A systematic assessment and treatment of sleep-disordered breathing is probably of interest in these patients.

Adult↗

[Bilateral labio-maxillo-palatal clefts. Therapeutic evaluation].

The wide diversity of bilateral facial clefts makes it most difficult to assess surgical success, particularly in terms of long-term outcome. The aim of this work was to examine the rationale for the current protocol used for cleft surgery at the Grenoble University Hospital. In a first group of 28 children, a 3-step surgical protocol was applied. The first two steps were performed between 4 and 8 months with at least 3 months between each procedure. Skoog's unilateral cheilo-rhino-uranoplasty was used, associated with a periosteal tibial graft. The third step, performed between 10 and 12 months, was for staphylorraphy. Outcome was analyzed at 15 years and evidenced the deleterious effect of excessive and asymmetrical premaxillary scars, of the 2-step cheiloplasty and of columella lengthenings from the lip. The frequency of secondary revision of the superior labial vestibule and the medial labial tubercule (43%) was considered to be high; this procedure should be re-examined as should be osteotomy (32% revision). Palatine closure, acquired in 82% of the cases and premaxillary stability, achieved in 86%, would appear to favor use of the periosteal tibial graft. The osteogenic capacity of this graft tissue was less satisfactory after a second harvesting (from the same tibia three months later). These results have led us to modify our protocol, favoring early and total closure of the bony palate and continued use of the periosteal tibial graft. We now use the following operative protocol: premaxillary alignment using an active orthopedic plate at 2 months, lip adhesion associated with staphylorraphy and passive palatine contention plate at 3 months, definitive bilateral cheilo-uranoplasty associated with a single periosteal graft at 7 months. The preliminary results with this protocol in a group of 12 children have shown better quality scars, more harmonious maxillary arches, an excellent occlusion of the deciduous dentition, and preservation of the positive results obtained with the periosteal tibial graft.

Adolescent↗

[The French Journal of Stomatology and Maxillofacial Surgery: what is the future?].

UNLABELLED: A scientific journal reflects the dynamics of a specialty and should allow wide diffusion of clinical as well as fundamental research findings in order for all practitioners to keep up with changes in their specialty. These objectives are totally different from a journal designed to meet teaching objectives where general reviews, technical notes or clinical cases are in the forefront. The purpose of this work was to determine the current role of the Revue de Stomatologie et de Chirurgie Maxillo-faciale in an attempt to determine future perspectives. MATERIAL AND METHODS: A Medline research was conducted for the period 1998-2000 to ascertain what French papers in the field of stomatology and maxillo-facial surgery had been published in indexed international reviews devoted to the specialty or related areas. The results obtained were compared with articles submitted for publication in the Revue de Stomatologie et de Chirurgie Maxillo-Faciale in 1999. RESULTS: Nineteen French papers were published in indexed international journals. These papers included 10 original articles, 8 cases reports and one technical note. The 10 original articles issued from 8 different centers and the 19 papers from 12 centers. During 1999, 96 papers were submitted to the Revue de Stomatologie et de Chirurgie Maxillo-Faciale for publication. Before acceptation, these papers included original articles (25%) case reports (45%) and technical notes or reviews (30%). In all, 18 original articles issuing from 10 different centers, the same centers that had published in the indexed international journals, were published. DISCUSSION: Considering that the substance of a scientific review lies in the abundance of its original articles, whether the work reports fundamental or clinical research, but more particularly clinical research for a surgery review, one is obliged to observe that the volume of French publications produced annually is insufficient to fullfil the objectives of a truly scientific journal. The 45% submission rate of case reports is in line with this observation. The number of international publications clearly does not explain this situation since globally, over a 2.5 year period, the number of original articles published was to order of one-third of the number published in the Revue de Stomatologie et de Chirurgie Maxillo-Faciale in the single year of 1999, and since the teams involved were the same.

Dental Research↗

A simulator for maxillofacial surgery integrating 3D cephalometry and orthodontia.

OBJECTIVES: This paper presents a new simulator for maxillofacial surgery that gathers the dental and maxillofacial analyses together into a single computer-assisted procedure. The idea is to first propose a repositioning of the maxilla via the introduction of 3D cephalometry applied to a 3D virtual model of the patient's skull. Orthodontic data are then integrated into this model, using optical measurements of plaster casts of the teeth. MATERIALS AND METHODS: The feasibility of the maxillofacial demonstrator was first evaluated on a dry skull. To simulate malformations (and thus simulate a "real" patient), the skull was modified and manually cut by the surgeon to generate a given maxillofacial malformation (with asymmetries in the sagittal, frontal, and axial planes). RESULTS: The validation of our simulator consisted of evaluating its ability to propose a bone repositioning diagnosis that would restore the skull to its original configuration. An initial qualitative validation is provided in this paper, with a 1.5-mm error in the repositioning diagnosis. CONCLUSIONS: These results mainly validate the concept of a maxillofacial numerical simulator that integrates 3D cephalometry and guarantees a correct dental occlusion.

Cephalometry↗

Obstructive sleep apnea syndrome. fifty-one consecutive patients treated by maxillofacial surgery.

The place of surgical treatment in obstructive sleep apnea syndrome (OSAS) remains unclear. Uvulopalatopharyngoplasty (UPPP) has a response rate of 41% overall and only 5% when retrolingual narrowing is present. Thus, in cases with suspected hypopharyngeal collapse maxillofacial surgery has been proposed with improved results. The Stanford group has designed a step-by-step surgical procedure tailored to the specific anatomical abnormalities encountered in each patient. The goal is to avoid a full maxillomandibular advancement osteotomy (MMO), at least in a subgroup of patients, beginning with a limited mandibular osteotomy (with or without hyoid myotomy and hyothyroidopexy and with or without UPPP) (phase 1 surgery). In this procedure MMO is performed as the second or third step (phase 2 surgery). The present study reports on our prospective experience with 51 consecutive patients (64 surgical procedures) treated by the step-by-step maxillofacial surgery previously described by the Stanford team. Only 2 of the 53 patients initially treated were lost for follow-up. Surgery was considered a success if the postoperative apnea and hypopnea index (AHI) was less than 15/h with at least a 50% reduction. Forty-four patients had phase 1 surgery. The success rate was 22.7% (10 of 44). The mean AHI was unchanged with a trend for reduction in the apnea index. Twenty patients had maxillomandibular advancement surgery (phase 2) (13 failures of phase 1, 7 patients primarily because of facioskeletal deformities). The AHI decreased from 59 +/- 29/h to 11 +/- 9/h after phase 2. Of the patients 75% (15 of 20) were considered to have had a successful outcome. In conclusion, phase 1 does not seem effective in most patients with OSAS. The results of phase 2 surgery are successful in young patients with severe OSAS even if the surgical technique is more aggressive.

Female↗

[Functional evaluation of intraoral reconstructive surgery. A valuable tool: articulatory evaluation of the acoustic signal].

Functional tests are needed to assess the quality of reconstructive surgery after treatment of intraoral cancers. Quality of Life tests are subjective and Cinefluoroscopy is a demanding and non-comparative procedure. We develop here a method to test the capacity of patients to maximize use of their articulatory space. We recorded a corpus of sounds. These sounds were analyzed with classical signal processing procedures. By comparison with a non-distorded sound database, it was possible to evaluate speech disorders, localize the defect, and provide a guide for rehabilitation. This method is an objective, reproductible, and comparative measurement tool.

Cohort Studies↗