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Biomedical subjects

G Berglund

Publications and source records attributed to G Berglund.

At least 307 records · Page 17Linked to original sources
PubMed1976

Anti-hypertensive action, time of onset and effects on carbohydrate metabolism of labetalol.

1 Seventeen men, aged 45-57 yr, with essential hypertension showed obvious and, in the standing position, dose-related reductions in blood pressure during treatment with oral labetalol with weekly dose increments. 2 Pulse rate changes were not related to dose but reduced compared with pre-treatment values. 3 No postural hypotension was recorded indicating lack of a dominant alpha-adrenoreceptor-blocking component. 4 There was a small increase in mean fasting blood glucose levels during labetalol treatment but no alteration in insulin activity or response to an oral glucose tolerance test.

Animals↗
PubMed1975

Renin-angiotensin system in essential hypertension.

In a random sample of normotensive and hypertensive fifty-year-old men plasma-renin-activity (P.R.A.), plasma-renin-concentration (P.R.C.), and renin substrate were measured using radioimmunoassay for angiotensin I. P.R.A. in normotensives and untreated hypertensives were normally distributed with slight skewness to the right. The mean P.R.A. for untreated hypertensives (0.65 ng. per ml. per hour) was slightly, but not significantly, lower than that of the normotensive reference group (0.78 ng. per ml. per hour). Previously untreated hypertensives who had been off treatment for four weeks had either high or low P.R.A. depending on the previous treatment. No differences in the angiotensin-generation rate were noted as judged from the P.R.A./P.R.C. ratio. No differences in the renin-substrate concentration between the groups were found. The findings suggest that renin changes in essential hypertenion are secondary to pressure changes. Thus, the renin-angiotensin system may not be of primary pathogenetic importance in the development of essential hypertension.

Angiotensin II↗
PubMed1975

Urinary noradrenaline excretion and renal function in normal and hypertensive 50-year-old men.

1. Sympathetic nervous system activity, measured by urinary noradrenaline excretion, was determined in a group of untreated hypertensive subjects (n = 35), a reference group (n = 80) and a normotensive group (n = 51), all derived from a random population sample of 50-year-old men. It was compared with casual and resting blood pressure, urinary sodium excretion, urinary cretinine concentration and glomerular filtration rate. Hypertension was defined as systolic pressure greater than 175 or diastolic greater than 115 mmHg on two separate occasions. Normotension was defined as systolic pressure less than 160 and diastolic pressure less than 95 mmHg. 2. There was no difference in the average excretion of noradrenaline during the day or night between the reference, normotensive and hypertensive groups. None of the hypertensive patients had values for urinary noradrenaline excretion during the day above the range found in normotensive subjects, indicating that hypertension with increased sympathetic nervous system activity is uncommon when hypertension in defined as above. 3. No correlation between urinary noradrenaline excretion during the day and blood pressure was found in the reference group or in the normotensive group. In the hypertensive group, there was a negative correlation between urinary noradrenaline excretion and blood pressure after rest. This finding might indicate that factors other than sympathetic nervous system activity determine the level of blood pressure in hypertensive subjects. 4. In the hypertensive group, urinary noradrenaline excretion during the day was positively correlated with both urinary sidium excretion during the day and glomerular filtration rate. Urinary noradrenaline excretion per 24 h was positively correlated with urinary sodium excretion during the same time. High resting blood pressure, low urinary sodium excretion, low glomerular filtration rate and a reversed diurnal rhythm of urinary excretion characterized hypertensive patients with low urinary noradrenaline excretion, indicating more severe hypertension in these hypertensive patients with reduced sympathetic nervous system activity.

Blood Pressure↗
PubMed1975

Minoxidil--haemodynamic and clinical experiences with a new peripheral vasodilator.

Minoxidil, a new peripheral vasodilator, given orally to hypertensive men in single doses of 5-25 mg, produced no haemodynamic changes within one hour after administration. After repeated oral doses within 24 hours to a total of 15-45 mg and after 10 mg t.i.d. orally for one week, moderate decreases in BP were seen concomitant with tendencies to increased heart rate and cardiac output. Clinically, oral minoxidil 10-50 mg daily in combination with diuretics and adrenergic beta-receptor blocking agents achieved an improved BP control in five patients with sustained arterial hypertension and unsatisfactory response to previous treatment. However, in four of the five patients minoxidil had to be withdrawn because of side-effects. It is concluded that minoxidil, producing a hypotensive effect of slow onset, may find a place as a therapeutic addition to symptomatic patients with severe and therapy-resistant hypertensive cardiovascular disease, provided adequate measures are taken to counteract side-effects, especially water retention and development of oedemas.

Adrenergic beta-Antagonists↗
PubMed1975

Factors related to blood pressure in a general population sample of Swedish men.

Blood pressure (BP), heart rate (HR), height, weight, hereditary factors, smoking habits and physical activity have been determined in a random population sample of men aged 47-54 years attending a screening examination, which was part of a multifactor primary preventive trial. Of the 9,967 men who were invited to the study, 83% answered a postal questionnaire and 75% took part in the screening examination. Of all persons not on antihypertensive treatment, 10% had systolic blood pressure (SBP) greater than 175 mmHg and 6% had diastolic blood pressure (DBP) greater than 115 mmHg. Of those on hypotensive treatment 43% had SBP greater than 175 mmHg and 30% had DBP greater than 115 mmHg, indicating that the hypertension was not well controlled. A weak positive correlation was found between HR and BP and between relative body weight (RBW) (defined as [weight/height] - 100) and BP. Both HR and RBW were higher in the treated hypertensives than in the remainder of the population studied. Subjects with a positive heredity for myocardial infarction or stroke had a significantly higher BP than persons with a negative heredity, but the absolute differences were small. A weak relationship was demonstrated between smoking habits and DBP, with the lowest BP in persons smoking greater than 25 cigarettes a day. There was no relationship between the degree of physical activity and BP.

Blood Pressure↗