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Biomedical subjects

G Benson

Publications and source records attributed to G Benson.

36 records · Page 2Linked to original sources
PubMed1994

Impact of parental substance use on adolescents: a test of a mediational model.

Tested a mediational model of the relationship between parental substance use and adolescents' substance (tobacco, alcohol, marijuana) use with data from a sample of 1,775 adolescents, mean age 13.3 years, who completed a questionnaire including constructs from three theories of substance use. Mediational analyses identified five constructs involved in the relationship of parental and adolescent use. A structural model with latent constructs for substance use showed indirect effects of parental substance use through greater tolerance for deviance, lower behavioral control, greater perceived coping function of substance use, more negative life events, and more affiliation with peer users, plus a direct effect. Implications for the theory of transmission of risk are considered.

Adaptation, Psychological↗
PubMed1993

A quantitatively controlled method to study prospectively interstitial cystitis and demonstrate the efficacy of pentosanpolysulfate.

A randomized, prospective, double-blind, placebo-controlled study was conducted at 7 clinical centers on 148 patients. Patients received orally either 100 mg. pentosanpolysulfate (a synthetic polysaccharide) 3 times per day or a placebo. Of the patients on drug therapy 32% showed significant improvement compared to 16% of those on placebo (p = 0.01). This study provides a model to assess this disease quantitatively in a prospective manner using a method whereby the patients globally assess their symptoms as either worse or improved by 0, 25, 50, 75 or 100%. Patients on drug therapy also experienced a significant decrease in pain and urgency (p = 0.04 and 0.01) on analogue scales when compared to placebo and also more drug patients showed an average increase of more than 20 ml. in voided volume than did placebo patients (p = 0.02). All adverse effects were minor, with 7 in the drug group and 10 in the placebo group. The results support the concept that some patients with the interstitial cystitis syndrome may have abnormal bladder surface glycosaminoglycans.

Aged↗
PubMed1993

Swaledale sheep affected by natural scrapie differ significantly in PrP genotype frequencies from healthy sheep and those selected for reduced incidence of scrapie.

PrP glycoprotein gene polymorphisms were examined in Swaledale sheep affected by natural scrapie, in healthy sheep and in Swaledales selected for low susceptibility to scrapie. The three groups differed significantly in frequencies of PrP genotypes detected by the restriction enzymes EcoRI, HindIII and BspHI, the latter being indicative of a PrP protein amino acid difference at codon 136. These frequency differences were confirmed in a single-flock study and present good evidence that scrapie susceptibility and resistance are associated with PrP gene variants in Swaledale sheep.

Age Factors↗
PubMed1993

Development of a theory of mind in individuals with mental retardation.

The ability of adolescents with mental retardation to reason about other people's mental states was examined. Subjects were asked questions about the knowledge and beliefs of characters in stories that they heard and saw enacted with props. The adolescents with mental retardation performed worse than did children without mental retardation matched for MA. The adolescents with mental retardation did better on questions requiring first-order reasoning than on those involving second-order reasoning; this pattern is similar to that found previously for children without mental retardation.

Adolescent↗
PubMed1992

The Norrie disease gene maps to a 150 kb region on chromosome Xp11.3.

Norrie disease is a human X-linked recessive disorder of unknown etiology characterized by congenital blindness, sensory neural deafness and mental retardation. This disease gene was previously linked to the DXS7 (L1.28) locus and the MAO genes in band Xp11.3. We report here fine physical mapping of the obligate region containing the Norrie disease gene (NDP) defined by a recombination and by the smallest submicroscopic chromosomal deletion associated with Norrie disease identified to date. Analysis, using in addition two overlapping YAC clones from this region, allowed orientation of the MAOA and MAOB genes in a 5'-3'-3'-5' configuration. A recombination event between a (GT)n polymorphism in intron 2 of the MAOB gene and the NDP locus, in a family previously reported to have a recombination between DXS7 and NDP, delineates a flanking marker telomeric to this disease gene. An anonymous DNA probe, dc12, present in one of the YACs and in a patient with a submicroscopic deletion which includes MAOA and MAOB but not L1.28, serves as a flanking marker centromeric to the disease gene. An Alu-PCR fragment from the right arm of the MAO YAC (YMAO.AluR) is not deleted in this patient and also delineates the centromeric extent of the obligate disease region. The apparent order of these loci is telomere ... DXS7-MAOA-MAOB-NDP-dc12-YMAO.AluR ... centromere. Together these data define the obligate region containing the NDP gene to a chromosomal segment less than 150 kb.

Base Sequence↗
PubMed1991

Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene.

The incubation period of scrapie in sheep is controlled by the Sip gene which has two alleles (sA and pA). Following experimental challenge with SSBP/1 scrapie, a short incubation period is conferred by the partially dominant sA allele. Restriction fragment length polymorphisms of the scrapie-associated fibril protein (PrP) gene are associated with the Sip alleles. By sequencing the protein coding region of the PrP gene in Cheviot sheep selected for differing Sip genotypes, we have found four PrP protein variants which differ at three positions: amino acid 112 (Ala/Val), amino acid 130 (Arg/His) and amino acid 147 (Arg/Gln). The Val 112 variant can be distinguished at the DNA level by an RspXI restriction site which is not present in the Ala 112 form. Val 112 appears to be linked to a short incubation period of experimentally induced scrapie in the Cheviot sheep and therefore with the Sip sA allele. These results provide new evidence that the PrP protein may be a product of the Sip locus.

Alleles↗
PubMed1991

Restriction fragment length polymorphisms of the scrapie-associated fibril protein (PrP) gene and their association with susceptibility to natural scrapie in British sheep.

We have investigated the correlation between restriction fragment length polymorphisms of the scrapie-associated fibril protein (PrP) gene and the incidence of natural scrapie in British sheep during the period from July 1988 to November 1990. Sixty percent of the scrapie-positive animals studied were homozygous for a 6.8 kb EcoRI fragment (e1) and a further 26% carried e1 as heterozygotes. This fragment is linked to susceptibility to experimental scrapie in a closed flock of Cheviot sheep. Twelve percent of cases were found to be homozygous for a 4.4 kb EcoRI fragment (e3) which in the Cheviot flock had been linked to relative resistance to scrapie. A third EcoRI fragment of 5.2 kb (e2) has also been found but is relatively rare and has not yet been associated with scrapie susceptibility. Four sets of flocks affected by natural outbreaks of scrapie divided into two groups. In three of these flocks, all scrapie cases carried e1 with high frequencies of e1e1 homozygotes. In the fourth, there were no e1e1 scrapie cases; all scrapie sheep carried e3 in approximately equal numbers of heterozygotes and homozygotes.

Animals↗
PubMed1985

Validity of questionnaires in population studies on drug use.

The concurrent validity of questionnaires in population studies on drug use was tested by comparing information from registers and interviews in two populations of young people from Gothenburg. The questionnaire items' sensitivity and specificity according to criteria and their capacity for prediction of drug use and no drug use and correct classification were calculated. Considering criteria weaknesses and other sources of errors, the validity of the questionnaire items was good. This conclusion is basic to longitudinal population studies which aim at clarifying the prognosis of drug abuse among young people.

Adolescent↗
PubMed1985

Course and outcome of drug abuse in military conscripts.

The course and outcome of drug abuse was studied by following a representative sample of military conscripts from Gothenburg who participated in a questionnaire survey concerning drug habits in 1969/70 in connection with registration for military service. Those with abuse registered in medical or social welfare files had, with few exceptions (11%), admitted to use of drugs in the questionnaire. However, 55% of those who in the questionnaire indicated high-frequency drug use and 89% of those who indicated low-frequency drug use were not registered. A large proportion of drug abuse was thus hidden. It was estimated that 6% of the whole population were registered for drug abuse up to the time of the questionnaire survey, and another 1% after that. In some cases registered drug abuse started as early as 9 years of age. For the under-fifteens solvents were the commonest first drug and for the over-fifteens cannabis. Few initiated drug abuse after the age of 20. In 30% of the registered men, the duration of abuse was less than or equal to 2 years, in 50% 2-10 years and in 20% less than or equal to 10 years. Distributed over the entire population, the proportions were 2%, 3% and 1%, respectively. Among high-frequency drugs users, 45% of the registered abuse remained after 5 years and 20% after 9 years. Compared with the drug-free "normal group" registered drug abusers had more often indicated running away from home, repeated truancy, nervous complaints, and had more often received child and youth psychiatric care and been registered with the Social Welfare Administration at an early age. Those who had long drug careers had lower intelligence levels than the normal group.

Adult↗
PubMed1985

Course and outcome of drug abuse and medical and social conditions in selected young drug abusers.

The course and outcome of drug abuse and medical and social conditions were investigated by following--in some aspects for up to 10 years--selected groups of young drug abusers who had had contact with health care and social welfare authorities in Gothenburg at the end of the 1960's. The follow-up was carried out by studying different registers and through interviews. The abusers were compared with a control group matched in terms of sex, age and daily sickness allowance. Abuse of cannabis predominated (2:1) over heavier drugs (primarily central stimulants i.v.) in the out-patient materials, while the reverse was the case in the in-patient material. About 40% of the drug users were interviewed and judged to be representative of their groups. After 4-6 years, 36-49% of the males and 23-48% of the females in the different materials were found registered as drug abusers; 22-38% of the men and 11-19% of the women were found after 8-10 years. According to the interviews, drug abuse persisted in 56-71% of the men and 26-60% of the women after 4-6 years and in 44-69% of the men and 13-36% of the women after 7-9 years. Abuse of cannabis persisted more often than abuse of heavier drugs, and had a lower mortality. Between 40 and 55% of drug abuse in the out-patient material, as well as among males in the social welfare material, was hidden during the follow-up period. The hidden abuse involved primarily cannabis; abuse of heavier drugs was generally known to the health care or social welfare authorities. Repeated or lengthy sick leave was more common than in the control group. In-patient adult psychiatric treatment was common among those in the health care material, although 40% of those in the social welfare material had also received such treatment. A diagnosis of drug abuse clearly predominated. Treatment of hepatitis was noted for 30-40%. More than 90% of drug abusers were registered with the social welfare authorities compared with less than half of the controls. Possession of driving licence was less common and the males had less often completed basic military training. The majority of those not registered for drug abuse after 4-6 years were employed or studying, and had considerably less need for social welfare and sick leave than those who were registered.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1984

Drug-related criminality among young people.

Drug-related criminality in Gothenburg, Sweden, was studied by following up criminal charges for stratified samples of unselected groups--ninth graders in 1968 and military conscripts in 1969/70--and selected groups--psychiatric patients and social welfare clients--of drug abusers. Cannabis was the predominant drug but central stimulants taken intravenously also occurred, particularly in the selected groups. During a follow-up period of 5-9 years cumulative criminality for men was twice as high among those who had stated high-frequency drug use in questionnaires, and four times as high among selected drug abusers, as the average in the unselected groups. Cumulative criminality was lower for women, but was nine times higher for women who had stated high-frequency drug use, and about 18 times higher for selected drug abusers, than was the average in the unselected groups. The most common drug-related crimes (in descending order) were crimes against property, against the Narcotics Drug Penal Act, and against the Road Traffic Offences Act. There was no significant increase in crimes against person. It is estimated that 25-50% of the criminals in the unselected groups of young men were drug abusers.

Adolescent↗
PubMed1984

Drug-related mortality in young people.

Mortality in young drug users in Gothenburg was studied, by following up, for about a decade, two unselected groups (ninth grade pupils and military conscripts), and selected groups of abusers from the files of the health and social welfare authorities. In the unselected groups, cannabis smoking predominated. Solvents, LSD, and central stimulants taken orally or intravenously also occurred, particularly in the selected groups. Polydrug abuse including alcohol was common, opiate abuse was rare. Observed mortality was compared with expected mortality in the same age groups. The mortality rate was significantly increased in several of the selected groups, 2.4-6.9 times in men and 1.3-7.9 times in women. Among pupils with high-frequency drug use it was increased 5.5 times in boys and not significantly increased in girls. Among pupils with low-frequency drug use it was not significantly increased in boys and increased 4.7 times in girls. Among registered pupils the mortality was increased 4.2 and 8.2 times in boys and girls respectively. Military conscripts did not display an increased mortality. The proportion of unnatural deaths was over 90%, which was significantly higher than in the population. About half of the deaths were suicides and undetermined suicides. The proportion of undetermined suicides was high among men. Two of the male deaths were homicides. In about one third of the deaths alcohol was involved. Dextropropoxyphene was present in five of the 14 intoxications among men. Although mortality was increased it is lower than in other Scandinavian studies. This may be explained by the relative youth of the abusers and the rare occurrence of opiate abuse.

Accidents↗
PubMed1984

Drug-related medical and social conditions in military conscripts.

Drug-related medical and social conditions were investigated in a sample of military conscripts from Gothenburg. The men participated in a questionnaire study concerning drug abuse in 1969/70 and were traced in different registers for 5 to 7 years. Abusers demonstrated an over-consumption of psychiatric and social care. Of all military conscripts, 4% had received in-patient psychiatric care. A total of 18% of those who were high-frequency drug users received the same care. The predominant diagnosis at the time of psychiatric treatment was drug abuse. 42% of all military conscripts were registered with the Social Welfare Administration, while the figure was 71% for high-frequency drug users. The proportion of those with repeated or lengthy sick leave was greatest among those who indicated use of drugs in the questionnaire. The proportion who had driving licenses was lower among drug users and 39% of the high-frequency drug users were granted exemption from military service during the inspection proceedings compared with less than 10% among the remaining groups. Cumulative frequencies of registrations showed that a number of curves were high for groups of drug users at an early stage and that the curves had not leveled off at the end of the follow-up period.

Adolescent↗
PubMed1984

Drug abuse in military conscripts. Prevalence and background.

A questionnaire investigation in 1969/70 concerning drug use among military conscripts constitutes the basis for a study of the course and outcome of drug abuse and of drug-related medical and social conditions. 19% of military conscripts from Gothenburg indicated that they had at some time used drugs compared with 11% in the whole country. Between 4 and 5% of the men in Gothenburg indicated current drug use. Of those with some drug experience, more than 40% had used drugs more than 10 times. Cannabis smoking predominated. These figures are probably an underestimate because of the pattern of selection for military service. Those who had used drugs had more frequently used solvents and also had more advanced habits as regards alcohol consumption and tobacco smoking. Their intelligence level was somewhat higher than others' but they were less well-adjusted at home and at school. They had more frequently been in contact with the police or the Social Welfare Administration and more often had nervous problems.

Adolescent↗