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Biomedical subjects

G Belloni

Publications and source records attributed to G Belloni.

At least 19 recordsLinked to original sources
PubMed1992

Carotid percutaneous angioplasty.

Clinical benefit from treatment of symptomatic severe carotid stenoses has been demonstrated recently. The safety profile of endarterectomy, however, justifies the development of alternative techniques as percutaneous transluminal angioplasty (PTA), at least in mild to moderate stenoses. Early results and follow-up data from our series of 44 carotid stenoses treated by PTA are reviewed in this paper, in comparison with other reports from literature. PTA may be beneficial as a therapy of symptomatic internal carotid stenoses, provided its cost/effectiveness has been evaluated by a valid method.

Angioplasty, Balloon↗
PubMed1992

Local intraarterial thrombolysis for acute stroke in the carotid artery territories.

We have tested the feasibility of local intraarterial thrombolytic therapy in ischemic stroke in the carotid artery territories observed within 5 h of the onset of symptoms. Only 5 of 615 consecutive patients were enrolled. They were 1 man and 4 women aged 50 to 75 years. Angiography disclosed occlusion of the M2 tract in one, of the M3 tract in one, of the carotid siphon in one of M4 tract in two. Intraarterial urokinase was infused at a mean dosage of 560,000 units close to the site of occlusion. Four of them had partial or complete recanalisation at early angiographic control and were independent at 6th month control. The one who did not demonstrate recanalisation was confined to a wheelchair. One patient, who had recanalisation, sustained a hemorrhagic transformation of the brain ischemia not interfering with outcome. Our experience, at the light of the low rate of enrollment, despite the results, suggest that intraarterial thrombolysis may be a therapeutic tool for selected patients with stroke in the carotid artery territories and not a routinary treatment for them.

Aged↗
PubMed1991

Percutaneous discectomy using Onik's method: 3 years' experience.

A total of 234 patients treated by percutaneous discectomy at 237 levels and followed-up between 11 months and 3 years 4 months showed an overall success rate of about 75%. In a subgroup of 112 of these patients rechecked for a second time, the clinical results remain consistently good even 24 months after surgery. In a special group of 28 patients who complained only of low back pain, percutaneous discectomy achieved a success rate of 85.7%. Complications consisted of one disc infection which cleared without clinical or radiological sequelae (0.26%).

Adolescent↗
PubMed1991

Alcoholic abstinence syndrome: short-term treatment with metadoxine.

The effects of metadoxine (pyrrolidone carboxylate of pyridoxine), a compound with central benzodiazepine-like properties, were evaluated in two groups of chronic alcoholics (inpatients) presenting a mild withdrawal syndrome. According to a double-blind study design 20 patients received metadoxine 900 mg twice daily eluted in 500 ml of saline infusion, while 20 (the control group) were given 500 ml of saline infusion twice daily with equivalent doses of pyridoxine (40 mg/die) every morning over a 10-day period. The results indicate that metadoxine treatment was able to control alcohol abstinence, thus allowing a reduction in the needs for standard benzodiazepine therapy. The central activity of gamma-aminobutyric acid of this compound might play a crucial role in the clinical effects demonstrated.

Adult↗
PubMed1989

[Echo-guided renal biopsy in patients with a medical nephropathy].

Ninety-five percutaneous renal biopsies under ultrasound guidance were performed on 89 patients with nephrologic diseases. Accurate diagnosis was reached in 93% of cases at the first biopsy, and the figure increased to 100% after a second biopsy. The use of 18 and 16 gauge needles allowed correct histological diagnosis in 95% of patients, and satisfactory histology in the extant 5%. US guidance and the use of 18 and 16 gauge needles reduced the complications related to renal biopsy: in fact, severe hematuria occurred in 2 cases only.

Adolescent↗
PubMed1988

Psychological distress in geriatric and adult medical in-patients.

Psychological distress was evaluated in two groups of medical in-patients, one composed of geriatric subjects (178), the other of adults (201). The instrument used for this purpose was the SCL-90. The predominant pattern of emotional response among the geriatric patients was depression; although this pattern was also present among the adult patients, reactions of an anxious type were more common in these subjects. Women of both groups of patients scored significantly higher than men on many of the subscales of the SCL-90. No significant differences emerged in relation to the type of organic disease among the adult patients, while among the geriatric patients, subjects with disorders of the CNS, muscular-skeletal system and blood scored significantly higher than those with other diseases.

Adult↗
PubMed1988

Treatment of anxiety with ketazolam in elderly patients.

In a multicenter, double-blind trial, 63 elderly patients who had experienced a generalized anxiety disorder for at least one month were randomly assigned to receive 15 mg of ketazolam (n = 31) or placebo (n = 32) daily for 15 days. At the end of this period, if their total scores on the Hamilton Anxiety Rating Scale had decreased by at least 25%, treatment was continued unchanged for a further 15 days. Patients who did not respond to treatment were given an additional 15 mg of ketazolam daily. During the initial 15 days, 83% of the ketazolam-treated patients and 43% of the placebo patients responded to treatment (P < 0.01). During the second 15-day period, the anxiety scores of the ketazolam-treated patients continued to decline significantly, whereas the placebo patients showed no improvement. According to the investigators' assessments of severity of anxiety and patients' ratings of treatment effectiveness, ketazolam was significantly superior to placebo.

Aged↗
PubMed1983

[Follicular carcinoma of the thyroid gland. Diagnostic and therapeutic considerations on 139 patients].

Records of 139 patients with pure follicular thyroid carcinoma were reviewed and correlations between survival rate, extent of tumor, surgical and radioiodine therapy were investigated. The survival rate at 10 years was good for younger patients (80% under 40 years of age) and without metastases (90%), but the prognosis was much less favorable for older patients (40% above 40 years of age) and subjects with distant metastases (20%), even if with radioiodine uptake. Diagnostic methods together with surgical and radiometabolic therapy are discussed. Since extensive histologic invasion of the capsule and blood vessels appeared to be associated with an increase in recurrence rate, the authors underline that radioiodine therapy is indicated in all these patients. Moreover they suggest its use also in less invasive follicular carcinoma.

Adenocarcinoma↗
PubMed1983

Screening for cytogenetic polymorphisms in a random sample of liveborn infants from Italian population.

The frequency of major and minor chromosome variants is studied in a random sample of newborns in Central Italy. Special attention is paid to the objective criteria used to evaluate minor variants. In our sample, the frequency of acrocentric chromosome variants is found to be unusually high compared with previous studies. Also, the distribution of C-band sizes differs from that reported for other populations, while the frequency of major chromosome variants is found to be the same.

Chromosome Banding↗