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Biomedical subjects

G Bauer

Publications and source records attributed to G Bauer.

At least 523 records · Page 29Linked to original sources
PubMed1977

Purification and further characterization of an RNA-dependent DNA polymerase from the allantoic fluid of leukosis-virus-free chicken eggs.

The purification of an RNA-dependent DNA polymerase from the allantoic fluid of uninfected, embryonated chicken eggs is described in detail. Comparison to the polymerase of avian myeloblastosis virus shows that the two enzymes are different with respect to ion concentrations for optimal reaction, response to increasing concentrations of substrate, thermal stability and protection from thermal inactivation by viral RNA. It is concluded that the enzymes compared to each other are different proteins, which must have been coded by different genes. The RNA-dependent DNA polymerase in the allantoic fluid, therefore, does not derive from the partial or complete expression of the endogenous virus genome of the normal chicken cell or from infection by exogenous viruses.

Allantois↗
PubMed1977

Selective stimulus-sensitive myoclonus in acute cerebral anoxia. A case report.

We report a 69-year-old patient, a chronic diabetic, who had a cardiac arrest after myocardial infarction. In the state of acute anoxic coma, massive myoclonic jerks occurred, and it was found that myoclonus could be elicited by light touch of the right trigeminal area (but of no other body region). The myoclonus was associated with complex EEG discharges against an almost flat background of activity. Findings of the autopsy showed cerebral edema with bilateral uncal herniation and prominence of the right cerebellar tonsil. Stimulus-sensitive myoclonus based on proprioceptive stimuli has been reported in chronic postanoxic states. This type of somatosensory elicitation seems to be extremely rare. We discuss the neurophysiological substratum; it is presumed that the cortex was still reached by the somatosensory stimuli.

Aged↗
PubMed1977

[The relation of electroencephalographic foci to vasospasms in patients with subarachnoid haemorrhage (author's transl)].

During a period of five years 74 patients with acute subarachnoid haemorrhage were controlled by angiography and EEG. 19 patients demonstrated angiographically proved intracranial aneurysms, seven intracerebral haematomas, three arteriovenous abnormalities. 25 patients had vasospasms. 34 patients showed foci in the EEG. Focal neurological abnormalities were in 43 patients. A correlation was established between EEG focus and vasospasm, focus and intracerebral haematoma. Further a relationship between focus and focal neurological abnormalities was detected. There was no correlation between EEG focus and aneurysm. It was claimed, that some foci in the EEG could be the result of persistent vasospasms.

Blood Vessels↗
PubMed1977

[The value of EEG after sleep deprivation (author's transl)].

Seventy seven adult epileptics and 30 patients with clinically non epileptic seizures were subject to a 24 hours sleep deprivation. The waking records of these patients were normal or unspecific abnormal. After sleep deprivation 29 (37%) of epileptics had abnormal EEG with epileptiform or focal activity, more often in cases with frequent (26 (60%) patients out of 43) epileptic seizures. Patients with sporadic attacks only exceptionally showed specific EEG changes (3 patients (8,8%) out of 34). Drug induced sleep emerged to be diagnostically less helpful. Twenty nine out of 30 patients with clinical nonepileptic seizures had no additional abnormalities in the EEG after sleep deprivation.

Adolescent↗
PubMed1977

Characterization of a new reverse transcriptase of possibly cellular origin in the chicken system.

The properties of an RNA-dependent DNA polymerase, which occurs ubiquitously in the allantoic fluid of uninfected, leukosis-virus-free eggs, are described. It is shown that the enzyme can synthesize faithful transcripts from natural RNA (globin mRNA). With biochemical and immunological methods, the enzyme can be clearly distinguished from the reverse transcriptases of the known chicken RNA tumour viruses and therefore seems to be a member of a so far unknown class of chicken polymerases. Our data show that in the chicken system reverse transcriptase can occur without connection to the replication of RNA tumour viruses and without relationship to the induction of malignancy.

Animals↗