Biomedical subjects

G Bauer

Publications and source records attributed to G Bauer.

At least 307 records · Page 17Linked to original sources

PubMed1994

Phenytoin overdosage and cerebellar atrophy in epileptic patients: clinical and MRI findings.

Mild overdosage of phenytoin produces reversible cerebellar symptoms (nystagmus, double vision, dysarthria and ataxia). Several case reports suggest that relatively mild and relatively short intoxication can lead to cerebellar degeneration. We observed 11 patients who had episodes of abnormally increased serum levels, most of which developed clinical signs of cerebellar dysfunction. All of these patients were examined with a 1.5-tesla whole-body system (Magnetom, Siemens). Five patients had normal cerebellar structures, although 3 of them had a history of clinical intoxication and all had at least one episode of increased serum level of diphenylhydantoin. The remaining 5 had moderate to severe cerebellar atrophy. Two of them never experienced signs of clinical intoxication. There was no correlation between degree of atrophy and severity of clinical symptoms and elevation of serum DPH levels. There was no correlation between cerebellar atrophy, duration of epilepsy and frequency of seizures.

Adult↗

PubMed1994

Epileptic seizures associated with intrathecal baclofen application.

We report the clinical and EEG findings in three patients presenting with seizures associated with intrathecal baclofen application for treatment of spasticity. All patients had a history of traumatic brain injury, while one patient also suffered a spinal cord injury. Two patients experienced their first seizure following intrathecal baclofen test bolus injection. Another patient had convulsions on two occasions: following postoperative baclofen dose adjustment, and after sleep deprivation. Structural brain disease seems prerequisite for baclofen to exert epileptogenic activity, since seizures have not occurred in patients receiving intrathecal baclofen for spasticity of solely spinal origin. Antiepileptic medication permitted the continuation of intrathecal baclofen treatment in the three patients.

Adolescent↗

PubMed1994

[Drug fatalities from the forensic medicine viewpoint. 10 years experiences of the Vienna Institute of Forensic Medicine].

The problem of illicit drug abuse has of course not spared Austria. In fact, considering only the increase in the official figures on drug-related deaths over the past few years, this problem has dramatically worsened in Austria. Drug-related deaths represent the most serious consequence of substance abuse, but according to the Pompidou Group classification such deaths are only one of eight indicators in assessing the extent of drug abuse in a community. We analyzed reports on all postmortems classified as drug-related deaths according to the official definition of the Austrian Federal Ministry of Internal Affairs undertaken at the Institute of Forensic Medicine in Vienna between 1984 and 1993. The annual number of drug-related deaths increased nearly ten-fold during the study period. In about a third of the cases accidental single substance overdosage (of mainly a morphine-containing drug) was the cause of death. In the majority of the corpses more than one drug, including alcohol, was detected. During the past 10 years there was an evident trend towards a multisubstance abuse pattern. Since the plateau reached in 1988, the incidence of HIV-1 infection among decreased drug injectors has decreased.

Adolescent↗

PubMed1994

[Epstein-Barr virus--significance of and possibilities in laboratory diagnosis].

The clinical symptoms of acute Epstein-Barr virus (EBV) serology infection may overlap with those of a variety of other infections and diseases; therefore, a significant EBV serology is of great importance for differential diagnosis. As the serological response after primary EBV infection may be highly variable, it is necessary to determine VCA-IgG, VCA-IgM and anti-EBNA-1 in parallel in all cases, in order to obtain conclusive results. Immunosuppressive disorders or treatment may lead to a specific loss of anti-EBNA-1 and thus mimic the serological situation of acute EBV infection. In these cases, determination of avidity of VCA-IgG may help to solve the problem. We also suggest to determine the EBV status, before the clinical significance of IgM directed against other viruses is being considered. This approach may help to distinguish clinical relevant IgM findings from IgM due to EBV-caused polyclonal stimulation.

Antigens, Viral↗

PubMed1994

Reversal of doxorubicin-impaired wound healing using Triad compound.

Triad is composed of Na pyruvate, vitamin E, and unsaturated fatty acids. We found that Triad, administered orally or topically, reverses wound healing that is impaired by doxorubicin (Doxo) in rats. Rats given Doxo (6 mg/kg IV) were wounded with linear dermal incisions, and the wound-breaking strength (WBS) was compared among groups of rats differently treated with TRIAD. Five groups of five rats each were studied. Triad was given orally using a 20 per cent TRIAD/rat chow mixture and topically as a 50 per cent TRIAD/petroleum base salve administered daily. All groups were wounded at postoperative day 0, at which time Doxo was given to groups II-IV. Group IV was fed oral TRIAD 7 days prior to wounding and until POD 21. All wounds were harvested at POD 21, and the mean WBS of each group was obtained using an Instron Tensiometer. Doxorubicin impaired normal wound healing by 40 per cent. Oral TRIAD restored WBS in Doxo-treated rats to 88 per cent of control values; topical TRIAD restored WBS to 80 per cent of control values. Moreover, treatment with topical TRIAD and oral TRIAD increased the WBS by 30 per cent and 50 per cent when compared with Doxo-only-treated animals. In conclusion, TRIAD has been shown to restore wound healing to nearly normal levels in doxorubicin-impaired wounds.

Administration, Oral↗

PubMed1994

Reversal of doxorubicin-impaired wound healing using triad compound.

Triad is composed of Na pyruvate, vitamin E, and unsaturated fatty acids. We found that Triad, administered orally or topically, reverses wound healing that is impaired by doxorubicin (Doxo) in rats. Rats given Doxo (6 mg/kg i.v.) were wounded with linear dermal incisions, and the wound-breaking strength (WBS) was compared among groups of rats differently treated with Triad. Five groups of five rats each were studied. Triad was given orally using a 20 per cent Triad/rat chow mixture and topically as a 50 per cent Triad/petroleum base salve administered daily. All groups were wounded at postoperative day 0, at which time Doxo was given to groups II-IV. Group IV was fed oral Triad 7 days prior to wounding and until POD 21. All wounds were harvested at POD 21, and the mean WBS of each group was obtained using an Instron Tensiometer. Doxorubicin impaired normal wound healing by 40 per cent. Oral Triad restored WBS in Doxo-treated rats to 88 per cent of control values; topical Triad restored WBS to 80 per cent of control values. Moreover, treatment with topical Triad and oral Triad increased the WBS by 30 per cent and 50 per cent when compared with Doxo-only-treated animals. In conclusion, Triad has been shown to restore wound healing to nearly normal levels in doxorubicin-impaired wounds.

Acrylic Resins↗

PubMed1993