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Biomedical subjects

G Barbolini

Publications and source records attributed to G Barbolini.

At least 37 records · Page 2Linked to original sources
PubMed1982

Early (stage A) prostatic cancer. VI. A critical look at the follow-up.

The 4 year follow-up of an original series of 100 patients treated by subtotal prostatectomy and analysed on histopathological grounds is presented. 87 out of 100 were traced and were in the following groups: 37/45 A1, 27/29 A2, 10/12 A3, 13/14 benign prostatic hyperplasia. No therapy was performed. All three patients who died of prostatic carcinoma fitted into substage A3, all three patients living with metastases fitted into A1. The progression observed is significant when related to the brief interval of time, the size of the prostatic microcarcinoma and the histological grade (well differentiated tubular carcinomas in 5 out of 6 cases). Prostatectomy with capsulectomy is strongly recommended in order to prevent progression.

Adenocarcinoma↗
PubMed1980

[Transcutaneous renal needle-biopsy guided with ultrasonics].

Authors performed percutaneous renal biopsy guided by ultrasounds in 10 patients in whom urography was dangerous or did not provided good renal images. The advantages of this method are in the directional and dimensional accuracy of ultrasound scanning, so that the exact topography of the kidney can be established. The use of ultrasonically guided renal biopsy is mainly recommended in iodine medium idiosyncrasy, in myelomas and renal failure. This method can be preferred in order to establish the exact topography of kidney, in acute anuric renal failure, in chronic failure (when high doses of iodate contrast are needed), and in the presence of cyst.

Adult↗
PubMed1980

Local treatment of neoplastic pleural effusions.

Efficacy of local treatment of neoplastic pleural effusions may be related to the administered drugs, as judged by our series of 225 patients. The evaluation of the local improvement--which did not interfere with the evolution of the primary cancer--showed good (45.9%) or satisfactory (48.6%) results in a series of 148 patients treated with peptichemio. This local improvement was practically devoid of any adverse side-effect even when the treatment was particularly prolonged. This survey deals with 15 years of therapeutical experience concerned with neoplastic pleural effusions from malignant epithelial tumours.

Dose-Response Relationship, Drug↗
PubMed1979

Early (stage A) prostatic cancer. IV. Methodological criteria for histopathological diagnosis.

This study was performed in order to elucidate some of the problems of incidence, morphology and natural history concerned with Stage A prostatic cancer or prostatic microcarcinoma (PMC). The prostates of 100 patients, treated by subtotal prostatectomy for benign prostatic hyperplasia (BPH), were studied by comparing both routine and step-section techniques. The incidence of PMC was 41% by the former and 86% by the latter technique. Assessment of the size of PMC, as measured by the sum of the two main diameters, resulted in three groups: A1, A2, A3. The last of these may represent a frankly malignant condition, judged by size and the histological appearance. Radical prostatectomy is strongly suggested as appropriate therapy for this group.

Aged↗
PubMed1977

A simple stain for nerve fibres.

A modification of Wilson's crystal violet staining for renin granules is able to show both centra and peripheral nerve fibres on paraffin sections with reproducible results. Fixation, pH and temperature are critical. This stain is considered to demonstrate nerve fibres on account of its capacity to combine with proteolipids.

Animals↗
PubMed1977

Histological and histochemical pattern of phytohemagglutinin (PHA) skin test in patients with sarcoidosis.

Phytohemagglutinin (PHA) is a non-specific stimulant of blastogenic transformation and proliferation of T-lymphocytes in vitro. This material has been used for detection of a reduced lymphoblastic transformation in vitro and, as a skin test, for providing information in the evaluation of cellular immunodeficiency in man (BLAESE et al. 1973). As in sarcoidosis the immunological features are "depression of delayed-type hypersensitivity suggesting T-cell anergy and raised serum immunoglobulins suggesting B-cell overactivity", the authors used PHA skin test in comparison with patients with tuberculosis and M. Hodgkin. PHA positive reactions recorded at 72 hrs. were in 95% for sarcoidosis, 90% for tuberculosis and 5% for M. Hodgkin. But the histological and histochemical investigation of cutaneous biopsies demonstrated three significant differences at 72 hrs. in untreated patients with sarcoidosis compared to the material of tuberculosis patients: formation of lymphatic pseudo-follicles, an increased number of arteriovenous anastomoses and appearance of C-mucopolysaccharide (a histochemical marker of connective tissue in sarcoidosis). There were in sarcoidosis, unlike tuberculosis, blast cells, plasmocytes and a number of lymphocytes at 72 hrs. It is difficult for the authors to explain the different behaviour of the PHA skin test in sarcoidosis and tuberculosis. The appearance of the C-mucopolysaccharide might be a result of the raised serum level of IgM in patients with sarcoidosis.

Glycosaminoglycans↗
PubMed1977

Non-specificity of crystal violet staining for renin granules.

This study deals with the histochemical specificity of crystal violet staining. Histological dyes such as crystal violet (CI 42555), ethyl violet (CI 42600) and methyl violet (CI 42535) are regularly employed for the assessment of juxtaglomerular granulation (WILSON 1952; FRIEDBERG and REID 1966; MARIUZZI and NENCI 1966). WILSON's modification of BOWIE's procedure is the staining method most frequently used for demonstration of 'renin granules' in the juxtaglomerular cells (JC). It has been assumed that JC granularity parallels renin-induced hypertension (PITTS 1968).

Animals↗