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Biomedical subjects

G Barabas

Publications and source records attributed to G Barabas.

At least 37 records · Page 2Linked to original sources
PubMed1984

Tourette's syndrome and migraine.

Among 60 patients with Tourette's syndrome (TS), whose mean age was 11.9 years, migraine was prevalent in 26.6%. This figure is substantially greater than that reported for the general population of school-aged children (4.0% to 7.4%) or for two control groups consisting of children with seizure disorders (n = 72) and learning disabilities (n = 62). The prevalence rates for these two control groups were 11.3% and 8.0%, respectively. The hypothesis is offered that the coexistence of TS and migraine in a subgroup of children with TS may reflect a similar abnormality underlying both conditions; specifically, neurohumoral dysfunction involving serotonin metabolism.

Adolescent↗
PubMed1984

Somnambulism in children with Tourette syndrome.

A total of 171 children, 57 with Tourette syndrome, 57 with learning disabilities and the rest with seizure disorders, were studied to discover the incidence of somnambulism. Of the 13 identified sleepwalkers, 10 had Tourette syndrome. It is argued that this may be due to a disturbance in serotonin metabolism.

Adolescent↗
PubMed1984

Disorders of arousal in Gilles de la Tourette's syndrome.

Disorders of arousal (somnambulism and night terrors) were significantly more common among children with Gilles de la Tourette's syndrome (n = 57) than among children with seizure disorders (n = 58) or learning disabilities (n = 53). Neurohumoral disturbances may account for the differences.

Adolescent↗
PubMed1984

Children with Tourette syndrome: results of psychological tests given prior to drug treatment.

There have been several recent reports on the neuropsychological integrity of children and adults with Tourette syndrome (TS). However, the possible effects of tic-controlling medications on the test performance of subjects have not been thoroughly investigated, although drugs commonly used in the treatment of TS, such as haloperidol, have been shown to affect learning and behavior. In this study, 10 children diagnosed as having Gilles de la Tourette syndrome were individually administered a battery of psychological tests prior to starting drug treatment. Since a wide range of deficits and processing inefficiencies has been reported in association with the psychological functioning of children with Tourette's disorder, the test battery used was designed to include both measures of contemporary global functioning and measures designed to focus upon particular functional areas. Data analyses revealed a number of specific impairments in TS children relative to age-appropriate levels and levels of global functioning (i.e., IQ scores). The study revealed a number of graphomotor, nonmotor visual-perceptual, and receptive verbal deficits. In addition, a high frequency (50%) of the sample manifested significant Verbal-Performance IQ discrepancies. Results of this study, on a population of nonmedicated TS children, substantiated and extended findings of several previous reports which identified a number of circumscribed weaknesses in the functioning of children with Tourette's disorder.

Adolescent↗
PubMed1983

Posterior rhythmic slow activity in EEG after eye closure.

During a 20 month period, EEGs in 7 patients, ages 6-16 years, showed a distinctive posterior rhythmic slow (PRS) activity brought on by eye closure. Following eye opening for 5-10 sec, eye closure on command was followed by a rhythmic high amplitude (100-250 microV) slow wave discharge of 3-4 c/sec lasting for 1.5-3 sec after a latency of 300-500 msec. Its distribution was limited to the occipital, posterior temporal and parietal regions. It was always bilaterally synchronous, occurred symmetrically or asymmetrically and fatigued easily. Of the 7 initial EEGs, only 2 had other EEG abnormalities. One patient, in a subsequent EEG, developed spontaneous PRS unrelated to eye closure. Clinical histories on the 7 patients showed 5 with various types of seizure disorders, 1 with attention deficit disorder, and 1 with Tourette syndrome. Neurological examination was normal in all patients, while computerized tomography or radioisotope brain scan was normal in 4. We suggest that PRS after eye closure represents a variant of the non-specific spontaneously occurring PRS described by Aird and Gastaut and others. It was found only in children and was not found to be helpful in diagnosing a seizure disorder or structural abnormality. Furthermore, such a discharge should not be interpreted as epileptiform activity.

Adolescent↗
PubMed1983

The family and the child with epilepsy.

Reports documenting psychosocial epiphenomena of chronic illness in individuals with that illness have been common in recent years. Few studies, however, have been concerned with how illness might affect the family. Those that have appeared in the literature often lack critical controls (i.e., control groups) and often fail to investigate possible links between illness-specific variables (i.e. chronicity, inhibition of mobility) and psychosocial outcomes on the family. The present study of 45 families focused on how children with epilepsy affect their families' functioning relative to families with a child with diabetes and families with no chronically ill members. The results suggest several areas of child and family adjustment (i.e. child self-concept, family communication, family cohesion) in which the families of epileptic children have great difficulty. Implications of these results are discussed with regard to differential influences of various chronic illnesses on families and family-based preventive and remedial treatment programs.

Child↗
PubMed1983

Childhood migraine and somnambulism.

Based on a sample of 222 children from four diagnostic groups, a high frequency of somnambulism in children suffering from migraine headache is reported. The strength of the association between somnambulism and childhood migraine raises the possibility that somnambulism might be considered as a minor diagnostic criterion in the clinical diagnosis of childhood migraine. This association may further clarify the nature of the serotonin abnormality underlying migraine.

Adolescent↗
PubMed1983

Coincident infantile autism and Tourette syndrome: a case report.

A 15-year-old boy who had been diagnosed as having infantile autism (IA) at two years of age was found to have Tourette Syndrome (TS) in adolescence. This case report represents the second coincident finding of IA and TS in an adolescent autistic boy. The implications of a co-occurrence of IA and TS are discussed in the light of our current understanding of abnormalities in neurotransmitter metabolism common to both conditions.

Adolescent↗
PubMed1983

Childhood migraine and motion sickness.

The incidence of motion sickness among 222 children in four diagnostic categories--migraine, nonmigraine headaches, seizure disorders, and learning disabilities--was compared. Motion sickness was found to be an associated feature in 45% of the cases of childhood migraine, in contrast to a 5% to 7% incidence in the other groups. Therefore, it is suggested that motion sickness be regarded as an additional reliable minor criterion in the diagnosis of childhood migraine. Hypotheses of common central and peripheral mechanisms underlying both conditions are offered.

Adolescent↗
PubMed1982

Emotional concomitants of childhood epilepsy.

On the basis of the distinguishing features of unpredictability, overt manifestation of symptom, and loss of control in epilepsy, a number of hypotheses about possible emotional concomitants of childhood epilepsy are offered. Comparing fifteen epileptic children with groups of diabetic and healthy children, matched for chronological age, sex, mental age, socioeconomic status, and family variables, the following findings emerged. Epileptic children are more likely than their diabetic or healthy peers to attribute control over even successful events in their lives to external sources. The perception of control by powerful others or by unknown factors was especially pronounced with regard to social events. In addition, epileptic children as a group were found to have lower self-concepts (particularly with regard to their popularity) and to be more anxious than their peers. The clinical and research significance of the findings are discussed.

Child↗
PubMed1980

Growth of murine cytomegalovirus in murine and heterologous brain cell cultures. Brief report.

Murine cytomegalovirus (MCMV) produced a cytopathic effect in mouse brain, guinea pig embryonic brain, human brain and fibroblast cells. Virus-specific antigen was detected by immunofluorescence in these cells after primary infection with MCMV. MCMV also replicated in ouse embryo brain and guinea pig brain cells. Although definite evidence of MCMV replication could not be demonstrated in human cells, MCMV infectivity was maintained for 12 days in human cell cultures.

Animals↗