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Biomedical subjects

G Bagdy

Publications and source records attributed to G Bagdy.

At least 73 records · Page 4Linked to original sources
PubMed1986

Platelet MAO activity and the dexamethasone suppression test in bipolar depression.

The correlation between postdexamethasone cortisol levels after the dexamethasone suppression test (DST) and platelet monoamine oxidase (MAO) activity was studied in 31 depressed female inpatients with Research Diagnostic Criteria primary, endogenous, bipolar depression (12 bipolar 1 and 19 bipolar 11). Out of the 31 patients, 25 showed abnormal DST results. Platelet MAO activity did not differ significantly from the matched control group. There was a trend that patients with higher MAO activity had lower postdexamethasone cortisol levels, but it was significant only for the 0800 hr cortisol levels.

Adult↗
PubMed1986

Measurement of platelet monoamine oxidase activity in healthy human volunteers.

Platelet MAO activity of 176 healthy volunteers was studied. Activity of the enzyme was found intraindividually stable, repeated measurements in the same individuals performed 3 weeks and one year later revealed only minimum changes. Platelet MAO activity was found to be significantly higher in females than in males. No age dependence of the measured values could be demonstrated. Enzyme activity values determined with different substrates showed a significant positive correlation. A significant activation of the enzyme was found after the addition of platelet poor plasma to the platelet preparation.

Adult↗
PubMed1985

Decrease in dopamine, its metabolites and noradrenaline in cerebrospinal fluid of schizophrenic patients after withdrawal of long-term neuroleptic treatment.

Dopamine (DA), homovanillic acid (HVA), dihydroxyphenylacetic acid (DOPAC), noradrenaline (NA), and 5-hydroxyindolacetic acid (5HIAA) were measured in cerebrospinal fluid (CSF) of 15 chronic schizophrenic patients before and 2 weeks after withdrawal of long-term neuroleptic treatment. Total neuroleptic-like activity in serum (NLA) was determined at the same times. Levels of DA and its metabolites (DOPAC and HVA) and NA were significantly reduced after the discontinuation of neuroleptic treatment. No change was observed in 5HIAA values. NLA was substantially reduced, but still remained detectable. The decrease in DA, DOPAC, and HVA all showed positive correlations with each other, and correlated negatively with NLA measured after 2 weeks. Our data implies that the decrease in DA turnover is the result of the discontinuance of DA receptor blockade, while the change in NA level is independent of it.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1985

CSF dopamine turnover and positive schizophrenic symptoms after withdrawal of long-term neuroleptic treatment.

Dopamine (DA), dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) were measured in cerebrospinal fluid (CSF) of 14 schizophrenic inpatients before and 2 weeks after withdrawal of long-term neuroleptic medication. Total neuroleptic-like activity (NLA) in serum was determined at the same times. DA and its metabolites (DOPAC and HVA) were significantly reduced after neuroleptic discontinuation. NLA was substantially diminished. The decrease in DA and DOPAC was positively correlated with positive symptoms of postwithdrawal deterioration, and low prewithdrawal DOPAC level predicted severe relapse. These results are compatible with the hypothesis linking an overregulated central DA system to the positive symptoms of schizophrenia.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1985

Changes in mental condition, hyperkinesias and biochemical parameters after withdrawal of chronic neuroleptic treatment.

Neuroleptics were withdrawn abruptly from 14 hospitalized chronic schizophrenics. For 12 weeks the patients were observed from the aspect of psychic change and the development of withdrawal dyskinesia. Serum prolactin level, plasma dopamine-beta-hydroxylase activity, cerebrospinal fluid homovanillic acid and norepinephrine levels were measured on the day prior to withdrawal and on day 14 of the study. Psychic deterioration showed no association with any of the tested biochemical parameters. The decrease in the CSF HVA and NE levels of the patients displaying symptoms of withdrawal dyskinesia was significantly smaller than in those displaying no dyskinesia.

Adult↗
PubMed1985

Tiapride in the treatment of tardive dyskinesia: a clinical and biochemical study.

The effect of tiapride treatment was investigated in 10 patients with tardive dyskinesia. The effects of the drug on the symptoms of tardive dyskinesia, parkinsonian symptoms, and patients' mental conditions were evaluated using standardized rating scales before and weekly during the 28-day drug trial. Patients were reassessed 14 days after withdrawal of tiapride. The symptoms of tardive dyskinesia significantly improved during treatment and deteriorated after tiapride was withdrawn. Parkinsonian symptoms remained unchanged both during and after treatment. The patients' mental conditions significantly improved while they were taking tiapride, and did not appreciably deteriorate after treatment was discontinued. Plasma prolactin levels increased significantly during treatment, while plasma dopamine-beta-hydroxylase activity did not change.

Adult↗
PubMed1984

Comparative neurochemical investigation of tardive dyskinesia and neuroleptic-induced chronic parkinsonism.

Cerebrospinal fluid (CSF) homovanillic acid (HVA), cyclic adenosine 3', 5'-monophosphate (cAMP), and serum prolactin were measured in schizophrenic male patients with tardive dyskinesia (TD) and in those exhibiting the symptoms of chronic neuroleptic parkinsonism (P). The patients (nine TD and eight P) were chronic paranoid schizophrenics. Levels of HVA in CSF were found to be significantly higher in the TD group. Normal prolactin levels were observed in both groups and are indicative of tolerance developed in the hypothalamic tuberoinfundibular dopaminergic system.

Adult↗
PubMed1984

Biochemical markers in the study of clinical effects and extrapyramidal side effects of neuroleptics.

Neuroleptic treatment was instituted in 20 female schizophrenic patients, who had not received neuroleptics for at least the preceding 3 months. Both the therapeutic response to neuroleptics and the development of parkinsonian side effects were monitored in these patients. In addition, plasma dopamine-beta-hydroxylase (DBH) and platelet monoamine oxidase (MAO) activities were measured. None of the neuroleptic responders developed parkinsonian symptoms. During the course of the 28-day treatment, there was a significant decrease in platelet MAO activity. There was a tendency for responders without parkinsonian symptoms to have lower plasma DBH activity than did nonresponders with parkinsonian symptoms.

Adult↗
PubMed1983

Comparative analysis of indices of central dopaminergic functions in man.

Various postulated indices of central dopaminergic activity - cerebrospinal fluid (CSF) dopamine (DA), dihydroxy-phenylacetic acid (DOPAC), homovanillic acid (HVA), noradrenaline (NA), plasma NA, serum prolactin, serum dopamine-hydroxylase (DBH), and platelet monoamine oxidase (MAO) activity - were measured in 30 drug-free inpatients. The mean values and the ranges were similar to those described in the literature. Plasma NA showed significant positive correlation with age. Significant positive correlation was found between CSF DA and its metabolites DOPAC and HVA. Serum DBH activity showed a slight but significant inverse correlation with CSF DA and its two metabolites. CSF NA showed a significant positive correlation with CSF DOPAC, but only in females. Serum DBH activity had no significant correlation either with CSF or with plasma NA levels. These findings suggest that either CSF HVA or DOPAC and DA may be useful indicators of DA metabolism in humans. Serum DBH activity may be in relationship with the central dopaminergic functions.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1983

Reduced serum dopamine-beta-hydroxylase activity in paranoid schizophrenics.

The serum dopamine-beta-hydroxylase activity of 134 carefully selected paranoid schizophrenic patients was compared with that of 118 normal controls. Significantly reduced serum DBH activity found in the schizophrenic group in comparison to the control group could not be brought into relationship with the patients' age, nor with neuroleptic treatment. Manic depressive patients showed values similar to the normal control group. It is discussed that mainly genetically determined low serum DBH activity may be related to the hyperdopaminergic pathomechanism of paranoid schizophrenia.

Aging↗
PubMed1983

Association between high platelet MAO activity and response to MAO inhibitor in depressed bipolars: case reports.

The authors describe two female patients with bipolar I depression who did not respond to tricyclic antidepressants in their previous depressive episodes and were prophylactic lithium nonresponders. Both patients showed a high pretreatment platelet MAO activity and responded well and rapidly to monoamine oxidase inhibition (MAOI) treatment. These findings suggest that although bipolar depressed patients show a low platelet MAO activity, there may be a subgroup with high enzyme activity. These patients revealed a low tendency to respond to tricyclic antidepressants and showed rapid improvement on MAOI therapy.

Bipolar Disorder↗
PubMed1983

An early phase II trial with L-deprenyl for the treatment of neuroleptic-induced parkinsonism.

The effect of L-deprenyl on neuroleptic-induced parkinsonism was evaluated in eleven patients. No significant improvement was observed during the treatment with L-deprenyl in the overall assessment. Four patients, however, were considered responders as their total scores on the modified version of Neurological Rating Scale decreased by at least 50%. No somatic or mental complications were observed during the study. The pretreatment platelet monoamine oxidase activity of the responders was slightly but not significantly higher than that of the non-responders. The plasma prolactin (PRL) levels of the patients with high pretreatment levels decreased significantly during the administration of L-deprenyl.

Adult↗
PubMed1983

Reduced platelet MAO activity in healthy male students with blood group O.

The association between the two genetic markers of affective disorders, ABO blood group system and platelet MAO (monoamine oxidase) activity was studied in 70 healthy young males. The platelet MAO activity of subjects with blood type O was significantly lower than that of subjects with blood type A and with blood types A + B AB + B together. This finding could constitute a "bridge" between the two genetic approaches to affective disorders.

ABO Blood-Group System↗
PubMed1982

Neuroendocrine study of the mechanism of action of electroconvulsive therapy.

The authors' earlier studies indicated that prolactin (PRL) response to electroconvulsive therapy (ECT) was not the result of stress reaction, because the secretion of other stress-sensitive hormones showed no parallel increase. The results of the present investigation are consistent with this findings as diazepam pretreatment failed to influence the PRL response induced by ECT. The rise of the serum PRL level was accompanied by a slight but significant decrease of the serum dopamine-beta-hydroxylase activity. A significant negative correlation was found between baseline serum dopamine-beta-hydroxylase activity and PRL response. These data indicate a correlation between serum dopamine-beta-hydroxylase activity and central dopaminergic function. PRL response to ECT is supposed to be the result of the dopaminergic action of ECT.

Adult↗