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Biomedical subjects

G B WEST

Publications and source records attributed to G B WEST.

At least 37 records · Page 2Linked to original sources
PubMed1963

Studies on wound healing.

Factors affecting the rate of healing of experimental skin wounds in rats have been investigated. The effectiveness of healing was measured by determining the tensile strengths of the incised skin after various time intervals. When the skin histamine content was lowered by treatment with polymyxin B or with compound 48/80, retardation of the healing process was evident from the reduced tensile strengths. When the skin 5-hydroxytryptamine content was lowered by treatment with reserpine, retardation of healing was also found. Heparin increased the rate of healing and more rapid healing was obtained by giving histamine before each dose of heparin. On the other hand, some glucocorticoids markedly inhibited the healing process. Of the constituents of the tissue mast cells, heparin appears to be more important than histamine and 5-hydroxytryptamine in promoting the healing of experimental skin wounds in rats.

Adrenalectomy↗
PubMed1963

Rats resistant to the dextran anaphylactoid reaction.

In one colony of Wistar albino rats 23% were resistant to dextran and to egg-white, these animals (non-reactors) failing to show an anaphylactoid reaction after the intraperitoneal or intravenous injection of either of the two substances. Non-reactors were also found in a few other colonies of Wistar rats but not in colonies of other strains. Procedures which potentiated the anaphylactoid reaction in sensitive rats (reactors) did not alter the response of non-reactors. Dextran failed to release histamine from the perfused hind-quarters of non-reactors although other chemical liberators of histamine were effective. Lack of anaphylactoid reaction was not due to a deficiency of skin histamine or 5-hydroxytryptamine, and the blood sugar and serum protein levels of non-reactors were also normal. Non-reactors could be sensitized to antigens and their serum was antigenic to guinea-pigs. It is suggested that non-reactors lack a blood or tissue component with which dextran normally combines to produce an intermediate substance active in releasing amines.

Amines↗