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Biomedical subjects

G B Fedoseev

Publications and source records attributed to G B Fedoseev.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

[Use of the expired air condensate in the study of biochemistry of bronchial contents in patients with bronchial asthma].

A total of 7 patients with premorbid adjustment (PA) and 13 patients with bronchial asthma (BA) were comparatively studied for the content of calcium, magnesium and biogenic amines (histamine, serotonin) which were assessed with atom absorption spectrophotometry and fluorimetry in the condensate of expired air (CEA), fluid of the bronchial wash-off (FBW) and bronchoalveolar lavage (BAL). It was revealed that the studied values in CEA were similar to those in FBW and BAL. The results obtained indicated that CEA adequately demonstrated the biochemical composition of bronchial contents in various generations and alveoli. CEA availability and high informative value permitted it to be employed in the research into the mechanisms of bronchial obstruction as well as in the control for the efficacy of BA and PA treatment.

Adolescent↗
PubMedDate not supplied

The study of pathogenetic basis of asthma using biostatistic models.

In 50 patients with asthma we have determined skin tests on dust and pollen allergens, forced expiratory volume for one second (FEV1) before and after subcutaneous injections of epinephrine standard dose, adrenoreactivity by adrenodependent cyclic AMP levels and glycogenolysis, cyclic AMP phosphodiesterase activity, levels of eosinophils in blood (in all 28 characteristic features). Factor and correlation analysis were carried out by electronic computer. In addition, in 121 patients we have determined adrenodependent glycogenolysis in leucocyte suspension incubated with various allergens the content of diene conjugates and total antioxidative activity of plasma. It is concluded that atopic and nonatopic forms of asthma are diseases of different nature in their constitutional origin, pathogenic agents of environment and cellular and subcellular mechanisms of their development. Moreover, the pathogenetic role of allergen-induced lipid peroxidation that correlates with lymphocyte adrenoreactivity is shown.

Allergens↗