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Biomedical subjects

G B Colver

Publications and source records attributed to G B Colver.

At least 37 records · Page 2Linked to original sources
PubMed1989

Failure of a helium-neon laser to affect components of wound healing in vitro.

The red light of a helium-neon (He-Ne) laser has been reported to stimulate wound healing and cell growth. To investigate the nature of its influence on wound healing we have studied seven components of the healing process in vitro: human skin fibroblast, epithelial and endothelial cell proliferation, cellular migration from skin explants, collagen lattice contraction, collagen synthesis and glycosaminoglycans (GAG) secretion. We used a 5 mW He-Ne laser emitting a I mm diameter beam of wavelength 633 nm. Cellular proliferation was not affected by irradiation three times a day for 3 days. There was no effect on cellular migration or on the rate of collagen lattice contraction. The rate of collagen synthesis, measured as the incorporation of 3H-proline into collagenase-sensitive protein, was no greater than that of controls and GAG secretion did not increase in the irradiated group. We have not found any significant effects of He-Ne irradiation.

Cell Division↗
PubMed1989

The infrared coagulator in dermatology.

The infrared coagulator was developed 10 years ago in West Germany. It shares some properties with an infrared laser but differs by virtue of its noncoherent, multispectral light source. It has evolved to become a cheap, portable instrument with a wide spectrum of applications in medicine, including dermatology. The treatment of tattoos and vascular lesions with the infrared coagulator is discussed, along with the technical considerations and limitations associated with this instrument.

Animals↗
PubMed1988

Cyproterone acetate and two doses of oestrogen in female acne; a double-blind comparison.

Cyproterone acetate was used in combination with either 35 or 50 micrograms ethinyl oestradiol in a double-blind comparison of their effects on acne in females. There were no significant differences between the two groups in the degree of improvement in acne as assessed objectively by the investigators, or subjectively by the patients using a visual analogue scale. Oestrogen related side-effects were significantly lower in the 35 micrograms group during the course of the 9-month study.

Acne Vulgaris↗
PubMed1987

Venous lakes: treatment by infrared coagulation.

A new treatment for venous lakes (Bean and Walsh, 1956) has been devised using an infrared coagulator. The solid light guide with its sapphire cap enables the ectatic vessels to be compressed prior to coagulation, minimising the energy required to destroy the vessels. We have successfully treated 10 lesions with a pulse duration of 1.125 seconds.

Humans↗
PubMed1987

Tattoo removal using infra-red coagulation: a dose comparison.

Using an infra-red coagulator, 42 tattoos were treated using pulses of 1.125 s (27 tattoos) or 1.25 s (15 tattoos). Treatment failures occurred only in three professional tattoos. Amateur tattoos were satisfactorily treated in over 80% of cases regardless of dose. Deeper collagen necrosis occurred with 1.25 s, but scarring was clinically similar. Pre-treatment biopsy to assess pigment depth was of no value in selection of the optimum pulse duration and increased the complication rate. The possible mechanism of pigment removal is discussed.

Dermatologic Surgical Procedures↗
PubMed1987

Is childhood idiopathic atrophy of the nails due to lichen planus?

Four children with symptomless or 'idiopathic' atrophy of the nails were studied. There were no other cutaneous signs. A longitudinal nail biopsy was performed on each patient and demonstrated active lichen planus in three cases and changes consistent with scarring lichen planus in the fourth.

Atrophy↗
PubMed1987

Herpes simplex virus dispersal by Hyfrecator electrodes.

The dispersal of herpes virus by electrodes has been studied. A Birtcher Hyfrecator electrode was used to treat skin biopsy samples to simulate the clinical setting. Discharge of the electrode over a drop of dye demonstrated that droplets can be showered over 5 cm. The virus could survive on a contaminated electrode at room temperature for at least 5 min. Contaminated electrodes were not sterilized by electrical discharge, and virus transfer to skin samples was demonstrated after contact treatment. Virus could not be recovered from probes after treating contaminated skin samples. We conclude that it is essential to sterilize probes between patients to avoid transmission of infection.

Electric Stimulation Therapy↗
PubMed1987

Port wine stains.

Explore the source record for details and available documents.

Facial Neoplasms↗
PubMed1986

The treatment of cutaneous vascular lesions with the infra-red coagulator: a preliminary report.

The treatment of vascular naevi with lasers is widely practised. The concept of specific vascular damage was an early ideal but it is much harder to attain than had been anticipated. The favourable results achieved by coagulation necrosis of the epidermis and upper dermis with the argon and CO2 lasers prompted us to try to produce the same changes with non-laser radiation. We have used an infra-red coagulator to treat flat vascular naevi and ectatic blood vessels. The handpiece which looks like a gun has a light guide capped by a 6 mm diameter sapphire. This size combined with a pulse duration of less than 1.0 second enables large areas of skin to be treated quickly. Preliminary results are presented.

Humans↗
PubMed1986

Atypical malignant melanoma of the nail apparatus.

Malignant melanoma of the nail is a serious disease with a five year survival rate of between 21% (Booher & Pack, 1957) and 50% (Graham, 1973). The diagnosis of atypical cases ultimately depends on interpreting histological material. We report here a case in which two initial biopsies of the affected nail failed to show malignant melanoma. The diagnosis was eventually made by formal longitudinal nail biopsy including matrix tissue proximal to the dystrophic area, and examination of sections cut at several levels.

Adult↗
PubMed1986

Precise dermal damage with an infrared coagulator.

Using an infrared coagulator, we have shown, in pigskin, a direct relationship between depth of injury and the duration of infra-red pulses, which was highly reproducible at a particular site. This has been related to the clinical results achieved in one patient whose three tattoos were treated with different pulse times.

Adult↗