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Biomedical subjects

G Aurich

Publications and source records attributed to G Aurich.

At least 37 records · Page 2Linked to original sources
PubMed1976

[Prerequisites and possibilities of immunotherapy in acute leukemias].

Nowadays there are references that immuno-reactions of patients with carcinoma against tumour-associated antigens are of essential significance for the development and progressing of tumours. Also the frequent appearance of neoplasms in primary immunodeficiency syndromes indicates this fact. Also in human leukaemias there exist leukaemia-associated antigens. Humoral as well as cell-bound immunoreactions may be proved. Possibly leukaemia-associated immunoglobulins are blocking factors which prevent the cellular immunoreactions against leukaemia-associated membrane antigens. The presence of specific reactions against antigens on leukaemia-cells was the condition for a successful immunotherapy. Despite many theoretical possibilities the immunotherapy in the clinic at present restricts to the BCG-vaccination and to the application of living or irradiated leukaemia-cells. The hitherto reported results are encouraging.

Acute Disease↗
PubMed1976

[Studies on the epidemiology of malignant tumors, systemic diseases and leukemia in children (author's transl)].

The analysis of statistical data on the incidence of leukemia in children in the German Democratic Republic between 1968 and 1973 gives no evidence for increasing risk of disease. Incidence in the G.D.R. is about the same as reported in literature. It seems that in the etiology and natural history of malignant tumors and hemoblastosis in children, constitutional and genetic as well as environmental factors are involved. They may work single or combined. Probably, malignant tumors or malignant systemic disease arise if the immune system fails to destroy endogenous or transplanted tumor cells.

Adolescent↗
PubMed1976

[Age-dependence of the cellular immune reaction in childhood. 1. Studies on healthy children and disease pictures with secondary modification of the immune apparatus (without leukoses and tumors)].

The dependence on age of the rates of transformation of lymphocytes is due not only to the different number and degree of maturity of lymph cells, but also to the macrophageal function as well as the feedback mechanism of specific and nonspecific defense reactions. Premature and newborn infants do not differ in their cellular immunoreactions. Between birth and the fifth year of life there is a continuous increase in the rates of transformation of lymphocytes. This increase in rates of transformation is less marked between the fifth and twelfth years of life, with the transformation rate leveling off as age increases. Tests made using nonspecific antigens showed the rate of transformation to decrease with further increasing age. Testing with histocompatibility antigens showed no influences whatsoever. A striking result were higher rates of transformation observed in children with virus infections. The evaluation of cellular immunoreactions subsequent to infections or immunization is an important parameter for the immune system.

Adolescent↗
PubMed1976

[Changes in the cellular immune reaction in the course of acute lymphatic leukemia].

In a seven years course study the parameters of cellular immunoreaction were elaborated in more than 100 children by means of the lymphocyte transformation test and the macrophage migration inhibition test. The transformation response revealed a dependence on the stage, course of the disease and regime of therapy during the tests with unspecific, specific and tumorspecific antigens. Compared with all antigens the transformation in the first crisis and in the recidives is significantly lower than in the remission. In spite of continuous immunosuppressive therapy in a cytostatic treatment lasting for years, the increase of the transformation rates is concealed by the fact that a positive selection of children with favourable courses can be evaluated in single test groups with advancing time of illness. The results for the prognosis of the disease and the transformation rates depending on the age of disease and the cell type are identical. The result of reaction with leukaemic cells as antigens enables prognostic conclusions to be made during the time of remission. Tests with leukaemic cells in myeloic leukaemias reveal a marked dependence on stages. In lymphatic forms a proceeding influence of the responding capacity of the T-lymphocyte population must be assumed. The difference in the results of reaction in cells from different stages must be discussed in connection with a possible change of antigens.

Child↗
PubMed1976

[Studies on the effect of various kinds of cytostatic therapy on the cellular immune reaction in children with acute lymphatic leukemia].

Clinical and experimental findings on possible changes of the lymphocyte function during an immunosuppressive or cytostatic therapy respectively caused investigations to be made for explaining the connections existing between the influence of cellular immunoreaction and the use of different cytostatic regimes. Earlier findings on the influence of cellular immunoreaction after adding cytostatics to cultivated cells and investigations on the influence of the lymphocyte function in dependence on cytostatic therapy were used for comparison. Transformation and mitosis rates as well as necrosis rates and the result of macrophage migration inhibition are comparable parameters for influencing the lymphocyte function in children treated with cytostatics. Antimetabolites, vincristine, asparaginase and daunomycin will have less influence on the transformation rate as an expression of an immunosuppressive effect on only those cells responding in accordance with their kinetic phase. Cyclophosphamide will inhibit the transformation reaction more significantly. Examinations in children with different therapeutic regimes reveal a certain validity of therapy after the first statistical evaluation of the clinical material.

Child↗
PubMed1976

[Effect of immunotherapy on lymphocyte function in acute lymphatic leukemia].

During the immunotherapy children suffered from acute leukaemias will have a significantly higher transformation rate than at the beginning of the immunotherapy. This may be explained by an increase of the immunological competence as well as by an enhanced mobilization of lymphatic cells. Leukaemic blasts used for immunoinduction-therapy will have no higher transformation rates as antigens than those cells never contacted by children. During the immunotherapy an increase of transformation rates may be observed after administering unspecific antigens and in mixed cultures. In a retrospective manner the indication for immunotherapy may be checked again in children with immunotherapy on the basis of the clinical course and evaluation of the cellular immunoreaction.

BCG Vaccine↗
PubMed1976

[Age-dependence of the cellular immune reaction in childhood. 2. Studies on children with acute lymphatic leukemias].

Results of studies made using the lymphocyte transformation test for leukemic children showed that an evaluation of cellular immunoreactions subsequent to the administration of szecific and nonspecific antigens as well as in the mixed culture is inadequate to recognize the characteristics of age-specific changes. A comparison of the rates of transformation in healthy children with those of leukemic children showed that age-specific characteristics are superseded by disease-specific changes.

Age Factors↗