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Biomedical subjects

G Ardito

Publications and source records attributed to G Ardito.

At least 37 records · Page 2Linked to original sources
PubMed1987

Therapy for advanced thyroid cancer: treatment of a high risk case.

The treatment of a high risk case of an advanced thyroid cancer is reported. The patient had a thyroid cancer with metastatic lesions of the frontal bone, left temporal bone, left sacroiliac joint, lytic destruction of C6 and lytic lesion of C7. A pre-operative immobilization of the cervical spine was performed by a halo cast set on a corset of gypsum. After this, the patient underwent a thyroidectomy and, at the same time, a metallic plate was applied to immobilize C5-C7. A month after he underwent reoperative surgery to stabilize definitively the cervical spine. Subsequently he was treated by TCT and 131I subdivided in several cycles. The latest total body scan demonstrated a complete regression of secondary lesions.

Adenocarcinoma↗
PubMed1984

Influence of a constant magnetic field on human lymphocyte cultures.

The growing exposure to magnetic fields of a certain intensity could represent a serious hazard for our health. In the present note we analyze the effect of a 740 Gauss magnetic field on human lymphocyte cell cultures. From the analysis of our data it is possible to point out that this field produces an inhibition of the cell growth, while does not affect at all the sister chromatid exchange frequency of the chromosomes. Conversely we found a significant increase of chromosome aberrations in the exposed cells. The chromosome aberrations found were mostly gaps and breaks.

Adult↗
PubMed1983

[Location of acetylcholinesterase in axotomized ciliary ganglia].

In the present note we have investigated the cytochemical localization of acetylcholinesterase (AChE) in the chick ciliary ganglion (CG) after post-ganglionic axotomy obtained by ablation of the eyeball. Preliminary results show at quite early stages after axotomy a remarkable reduction of cytoplasmic AChE, the residual one being localized in the rough endoplasmic reticulum. On the contrary synaptic areas, in particular those concerning the calyciform synapses, still show a marked AchE activity, similarly to what observed in physiological conditions. The decrease of cytoplasmic AChe in axotomized CG does suggest the possibility that such AChE undergoes to a topographical rearrangement moving towards the synaptic areas of ganglionic neurons.

Acetylcholinesterase↗
PubMed1983

Analysis of cell kinetics, chromosome aberration frequency and sister chromatid exchanges in lymphocyte "in vitro" cultures of patients irradiated by 131I. Preliminary note.

In the present note we analyse the possible effect of 131I administration on lymphocyte cultures or patients previously subjected to thyroidectomy because of carcinoma. Three parameters were taken into consideration: cell kinetics, SCE frequency and chromosome aberrations frequency before and after treatment. It is possible to point out only an increase of chromosome aberrations. Our data stress the importance of considering several variables at the same time when we are faced with the problem of evaluating possible DNA damage.

Adult↗
PubMed1983

Cell kinetics and sister-chromatid-exchange frequency in human lymphocytes.

Repeated cultures from 5 healthy donors were set up in 3 tissue-culture media: TC109, TC199 and TC1640. For each donor, 3 blood samples were taken at 1-week intervals, making a total of 5 x 3 x 3 = 45 cultures. Our results show a large variability in the individual SCE base-line frequency. This variability can be partly attributed to the different tissue-culture media or to the donors themselves. Our results, however, stress the importance of the proliferating rate of the culture in determining the SCE frequency.

Cell Division↗
PubMed1983

The effect of cell kinetics and harvest time on SCE and NOR associations in Macaca fuscata lymphocytes.

The relationship between cell kinetics and cell harvest time on sister chromatid exchange (SCE) and NOR (marker chromosome) association was investigated in cultured Macaca fuscata lymphocytes. The average number of SCE's in individuals ranged from 3.77 to 9.07 per cell. The highest SCE rate was found in cultures harvested at 60 h. The data suggest a decrease in SCE frequency between 60 h and subsequent cell harvest at 72, 84, and 96 h. NOR association frequency was also affected by cell kinetics, as well as by cell harvest time. The highest association frequencies were at 48 h, when the number of first mitoses was greatest.

Animals↗
PubMed1983

The banded karyotypes of Macaca fuscata compared with Cercocebus aterrimus.

The karyotypes of Macaca fuscata and Cercocebus aterrimus are compared after G, C and AgNOR banding. Although it is often assumed that the 42-chromosome monkeys (species of the genera Macaca, Papio, and Cercocebus) are identical at the chromosomal level, a number of clear and consistent differences between the karyotypes of these two taxa are described. These differences include one pericentric inversion and differences in staining intensity, particularly in centromeric and pericentromeric areas. It is probable that high resolution chromosome techniques could reveal more differences between taxa in the 42-chromosome group than are now believed to exist. It is therefore probable that karyological data could provide insight into the phylogenetic relationships in this group of Old World monkeys.

Animals↗