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Biomedical subjects

G Anfossi

Publications and source records attributed to G Anfossi.

15 recordsLinked to original sources

Renal lactate dehydrogenase (LDH) isoenzyme pattern in short-term experimental obstructive nephropathy.

The lactate dehydrogenase isoenzyme pattern of different zones of rat kidney has been investigated at different stages after unilateral ureteral obstruction. In the obstructed kidney, the cortical tissue showed an early (3 days) progressive shift toward a cathodic zymogram; at 7 days LDH-5 isoenzyme was the predominant fraction (44.7 +/- 2.5). In the outer medullary tissue a similar change was observed even though middle fractions were always quite evident. No significant changes were found in the inner medullary tissue. The observed enzymatic abnormalities are related to renal hypoxia and to the occurrence of a less differentiated nephronic cell population. They represent a metabolic marker of the morphologic and functional alterations which occur in obstructive nephropathy.

Animals

[Acute calculous cholecystitis (author's transl)].

The authors studied 333 acute cholecystitis out of 2,200 operated on for lithiasis of the gall-bladder, 186 bacteriological tests were carried out on the vesicular liquid and wall. They insist on the main anatomo-pathological characteristic: early, partial or total destruction of the mucous together with acute inflammatory lesions of the wall and even sometimes necrosis. This irreversible lesion is due to the acute obstruction of the gall-bladder by blockage of a calculus. Acute cholecystitis are practically always aseptic at the beginning. Sepsis is a secondary complication. These anatomo-pathological and bacteriological elements have two therapeutic corollaries: 1. The patient has to be operated very early at the aseptic stage. 2. Preliminary antibiotherapy becomes useless. Under these conditions there is practically no death before the age of 65. Mortality concern old people, operated late and suffering from other disease.

Acute Disease

[Type B viral hepatitis. Recent findings].

The discovery of hepatitis B surface antigen by Blumberg in 1965 offered a specific marker that could readily be employed in the clinical, epidemiological and experimental investigation of type B viral hepatitis. It has since been followed by the continuous gathering of further knowledge concerning this disease. The morphology and immunological and biochemical features of virus B, the epidemiology and prevention of hepatitis B, and marker determination techniques are examined in an overview of the present situation.

Animals

[Results of a series of 100 highly selective vagotomies for duodenal ulcer (follow up of 6 months to 5 years) (author's transl)].

The authors analyse a series of 100 highly selective vagotomies for duodenal ulcer; 92 operated patients were followed up for 6 months to 5 years. The mortality was nil, the digestive sequelae were rare or mild. The recurrence rate was 4.4 p. cent and the proportion of good or very good results according to Visick's classification was 87 p. cent. The authors emphasise the necessity for broad dissection of the cardia for complete vagotomy.

Adult

[Congenital segmental duplication of the lumbar ureter (author's transl)].

In a 23-year-old man attacks of nephritic colic led to the discovery of an obstruction on the left lumbar ureter. Segmental resection of the ureter was performed, removing 10 mm of malformed, obstructed ureter. This was an incomplete duplication, the two ureteral segments lying side-by-side, each with its own musculature, for a distance of 7mm. Above and below the anomaly, the ureter was normal. This exceptional malformation is compared with other internal obstructions of the ureter.

Adult