[Exclusive use of pancuronium bromide as the only muscle relaxant in general anesthesia with intratracheal intubation].
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Biomedical subjects
Publications and source records attributed to G Amato.
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Thyroid function was explored in 27 CAPD patients and 25 HD patients. Dialysis was associated with low T3 and T4 levels, increased rT3 concentrations, normal T4 : T3 and reduced T4 : rT3 ratios, normal FT3 and Thyroglobulin concentrations. TSH levels increased during dialysis but still fell within normal limits. The data rule out a condition of primary hypothyroidism and point out to increased thyroidal dismission associated with the block T4-T3 in peripheral cells. Also the increased FT4 levels in CAPD patients could be due to de novo dismission of thyroidal T4.
The conditioning stimulation of the globus pallidus both in chronic and acute cats determined a more effective inhibition than caudate nucleus activation on the evoked paroxysmal activity in the amygdala. Lesions by means of kainic acid of the entopeduncular nucleus, has resulted in a significant decrease of the caudate inhibitory effect. The hypothesis we assumed is about a role of the globus pallidus in the control of the evoked amygdaloid after-discharge.
The conditioning stimulation of the substantia nigra both in chronic and acute cats determined a more effective inhibition than caudate nucleus activation on the evoked paroxysmal activity in the amygdala. Lesions of the substantia nigra by means of kainic acid, produced the disappearance of the inhibition induced by caudate nucleus. An examination of the obtained data and of the literature on this topic, allowed us to identify a possible nigro-amygdaloid direct pathway.
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Both in acute and chronic cats focal paroxysmal activity evoked in the ventro-basal complex of the amygdala has been inhibited by substantia nigra conditioning stimulation, to a greater extent, than by caudate nucleus activation. Injection of kainic acid into substantia nigra resulted in the disappearance of the caudate inhibition. It is suggested that the final control, exerted by the striatum on the amygdaloid seizures, occurs by means of the substantia nigra.
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In the present experiment, the participation of the internal part of the globus pallidus (GP) in the initiation and the execution of a pointing movement was investigated in four baboons (Papio papio). The effects of GP exclusion on the response latency, the movement execution time and the pointing accuracy were analyzed. Two different methods were used to exclude the GP. In two cases, cryogenic blockade was induced using a chronic cryoprobe, implanted contralaterally to the operant hand. Two other animals underwent a partial electrolytic destruction of the GP, contralateral to the active hand. The effects of GP exclusion on reaction times, movement times and pointing accuracy were compared for movements with variable amplitudes and directions. For all animals, the GP exclusion resulted in a decrease in reaction time, but an increase in movement time and spatial error. None of these modifications was increased by variations in the biomechanic characteristics of the movement. These data show that the GP, in baboons, is concerned with: (a) the initiation of a pointing movement (without playing a critical role in the encoding of amplitude and direction parameters); and (b) the execution of this movement. The possible involvement of the GP in sensory-motor integration, postural adjustments and muscular synergy is discussed.
The functional role of the putamen, in both initiation and execution of a motor act, was investigated in 3 baboons performing a visuomotor pointing task. Reversible blockade of the putamen differentially affected the spatiotemporal components of the response. The results stress the importance of the putamen in the triggering of a goal-directed movement, but show that this structure does not seem critically involved in the control of the speed and accuracy of the movement.
The indications for the employment of Althesin in caesarean section are explained and a substantially favourable opinion is expressed on its clinical effects. Absence of neonatal depression is attributed both to the distribution and metabolism of the drug, and to the features of foetal circulation at term.
Personal experience in minor surgery with Althesin alone (200 cases) and in association with hydroxyzine in the same syringe (250 cases) is reported. Comparison showed that the association is useful, particularly in cases where the operation lasts longer and involves greater pain stimuli. It is felt that the method described will extend the use of Althesin in minor surgery.
Personal experience of the behaviour of sodium, chlorine and potassium serum electrolytes in patients anaesthetized first with Althesin alone and then in association with succinylcholine is reported. Sodium and chlorine changes were slight whereas potassium concentrations fall in the first 5' before tending to rise. Used as an induction agent before succinylcholine, Althesin acts as a kind of protector against the increase in potassaemia which follows succinylcholine.
Personal experience with an association of Althesin and hydroxyzine administered in the same syringe in the induction and maintenance of anaesthesia for caesarean section is described. The technique proved to be sound, offering safe conditions for both mother and foetus, and absence of noteworthy side-effects, and a good post-operative analgesic effect. The overall results were better than those observed when TPS is used as the inducing agent.
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