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Biomedical subjects

G Amabile

Publications and source records attributed to G Amabile.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

P300 variations in parkinsonian patients before and during dopaminergic monotherapy: a suggested dopamine component in P300.

P300 was recorded, using an 'odd ball' paradigm, in 18 parkinsonian patients before and during dopaminergic monotherapy. The data were compared with those of a homogeneous standard group of 20 subjects. The main finding was an increase in the P300 latency of parkinsonian patients before therapy, which recovered during dopaminergic monotherapy. In 11 voluntary healthy subjects the same therapy did not produce a reduction of the P300 latency. The data are discussed in relation to a possible dopaminergic component in P300 origin.

Aged↗
PubMedDate not supplied

[Peripheral nerve damage in HIV infection].

A critical review of the literature concerning PNS involvement in HIV infection was carried out. This complication was detected a short time ago (1982) and therefore a common classification is not yet available. The authors, through an analysis of the cases reported in literature, suggest a nosographic classification of this pathology.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[Parkinson disease and cognitive evoked potentials].

The Authors introduce some questions concerning cognitive impairment in Parkinsonian patients and they focus the attention on 'bradyphrenia'. They briefly discuss the methodological difficulties in studying this kind of disturbances in Parkinson's disease (PD) and the approach to this problem with the help of the Event-Related Potentials or ERPs. Finally, they review literature and their data on Contingent Negative Variation (CNV) and P300 in PD and conclude that interesting and useful informations can be obtained by means of the electrophysiological methods.

Cognition Disorders↗
PubMedDate not supplied

[Iatrogenic neuropathy].

A variety of drugs have been reported to cause peripheral nerve dysfunction. A review on this topic is reported concerning a wide number of drugs commonly employed in the clinical practice. In the analysis of the possible neurotoxicity of the various drugs the following criteria were into account: typical clinical features, full or partial recovery after treatment suspension, possibility to reproduce clinical and morphological peripheral system alterations in experimental animal models.

Animals↗
PubMedDate not supplied

[Slow-release verapamil 240 mg and treatment of mild to moderate hypertension].

The study was carried out in association with medical practitioners who were responsible for observing the patients. Its aim was to determine the effective dosage of slow release verapamil (V) in the treatment of mild to moderate hypertension and to compare plasma concentrations of V with blood pressure effects. The study comprised a 2-week placebo period and a 3-month active treatment period with V, during which patients were examined, 20-24 h after last intake of V, at the end of the first (D30) and of the third (D90) month of treatment. Active treatment started with 240 mg of V (once a day); at D-30 if diastolic blood pressure (DBP) remained above 90 mmHg the dosage of V was increased to 480 mg (t.d.s.). At each examination blood pressure, body weight and heart rate were registered, electrocardiogram and routine biochemical tests were carried out; plasma concentration of V was measured at D30 for every patient and at D90 for those receiving 480 mg. of V. Thirty patients (11 men and 19 women) aged from 29 to 80 years (mean : 61.7) took part in the study. Treatment needed to be stopped in one patient; results are based on the other 29. At D30 systolic blood pressure (SBP) fell from 179.4 +/- 5.9 to 156.2 +/- 5,5 mmHg and DBP from 101.3 +/- 1.8 to 88.3 +/- 3 mmHg; DPB became normal (less than 90 mmHg) in 23 subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Pilomotor epilepsy.

The case is reported of a patient presenting pilomotor seizures as the initial symptom of a tumour of the deep temporal lobe. Six other cases had previously been reported with the same type of seizures. The responsible lesion was often a tumour in deep temporal lobe and the distribution of the piloerection attacks was almost always ipsilateral. Pilomotor seizures deserve a definite role in the nosography of partial epilepsy.

Brain Neoplasms↗
PubMedDate not supplied

[2 cases of mitochondrial encephalomyopathy].

Two cases of mitochondrial myopathy are described. An electrophysiological study was also accomplished to investigate the concomitant involvement of the central nervous system (CNS), by means of evoked potentials (EP). The EPs in fact can reveal minimal signs of CNS lesions also when muscular damage is the only clinical evidence.

Adult↗
PubMedDate not supplied

Event-related potentials and autonomic functions.

The authors pointed out how some of the anatomic structures involved in the genesis of the event related potentials (ERPs) are also considered parts of the supranuclear regulation apparatus of the autonomic nervous system. Since there are evident functional similarities between some components of the ERPs and the orienting reflex--primitive form of attention--that is clearly associated with an autonomic activation, it could be interesting to evaluate the parameters of the ERPs in those experimental and clinical situations in which there is a functional involvement of the vegetative nervous system.

Autonomic Nervous System↗