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Biomedical subjects

G Abate

Publications and source records attributed to G Abate.

At least 91 records · Page 5Linked to original sources
PubMed1980

[Ribostamycin in chronic and recurrent bronchopulmonary and urinary infections].

Results in the treatment of mostly Gram-negative infections of the respiratory apparatus (30 subjects) and the urinary apparatus (20 subjects) with ribostamycin are reported. These were regarded as good overall, as shown by the bacteriological findings. An extremely high sensitivity to the antibiotic was noted in isolated germs from both types of infection. This good response in vitro was matched by an equally encouraging bacteriological result in vivo.

Adult↗
PubMed1979

Effects of indomethacin on postural hypotension in Parkinsonism.

A study was conducted to evaluate the effect of indomethacin on orthostatic hypotension in Parkinsonism. Twelve elderly patients participated and the drug was given in two-ways--as an intravenous infusion of 50 mg over 30 minutes and by mouth 50 mg thrice daily for six days. Results were assessed by measuring the degree of hypotension on standing, response to the cold pressor test, and forearm blood flow (by strain-gauge plethysmography). Indomethacin significantly reduced the fall in blood pressure on standing (P less than 0:001) and lessened or reversed orthostatic symptoms. Furthermore, there was an enhanced response to the cold pressor test and a reduction in forearm blood flow. These findings suggest that indomethacin has a positive effect on systemic vascular resistance.

Administration, Oral↗
PubMed1979

Study of the metabolic effects of bunitrolol (Koe 1366) in angina induced by catecholamine infusion.

In ten angina patients responding with a myocardial anaerobic metabolic pattern to isoproterenol infusion, a new beta-blocking agent, bunitrolol, was effective in normalizing the myocardial lactate extraction ratio. The correlation with lipid metabolism was also interesting because beta-blocker action reduced significantly arterial non-esterified fatty acids (NEFA) level as well as myocardial NEFA extraction. The metabolic behavior suggests the effectiveness of bunitrolol in the treatment of ischemic heart disease.

Angina Pectoris↗
PubMed1978

[Effect of vitamin D and vitamin E on the erythrocyte membrane. I. Effect on in vitro osmolar resistance and lysis].

As in the case of retinol, low doses of cholecalcipherol and alpha-tocopherol "in vitro" increase the osmotic resistance of red blood cells, while high doses have a lytic effect on the erythrocytes of various animal species (e.g.: man, sheep, rabbit, guinea-pig, mouse, rat) with the exception of the chicken. The haemolytic effect of cholecalcipherol is less intense than that of retinol; alpha-tochopherol, while causing even less haemolysis than cholecalcipherol, involves a remarkable loss of K+ from the red cells. Besides these quantitative differences, the mechanism of action of the three vitamins seems somewhat different, as shown by modifications of the suspension medium (e.g.: pH, temperature, presence of proteins and reducing substances) or by treatment of the red cells with trypsin. Our results therefore essentially confirm the hypothesis of Dingle and Lucy of common mechanism of action of liposoluble vitamins on biological membranes.

Cholecalciferol↗
PubMed1978

[The antegrade GAPs (author's transl)].

GAP in a-v conduction is defined as a zone within the cardiac cycle where premature atrial impulses fail to evoke ventricular responses whereas atrial beats of greater and lesser prematurity do. This phenomenon occurs when the effective refractory period (ERP) of a distal site is greater than the functional refractory period (FRP) of a proximal site of the conduction system. To date, Damato and Co. classify antegrade gaps into six types on the basis of blocks location and proximal delay that permits conduction recovery: type I: HPS and AVN; type II: HPS (distal) and HPS (proximal); type III: HPS and His-bundle; type IV: AVN (distal) and AVN (proximal); type V: AVN or HPS and atrium; type pseudo-V: AVN or HPS and antrial miocardium proximal to stimulation site; type VI: HPS and supernormality (no proximal delay). The Authors propose, on the basis of 37 cases of GAP phenomenon observed in 185 electrophysiological studies, a new classification of antegrade gaps, which complete and partially modifies Damato's one. Tyes I-II-II-IV and V are divided into A and B forms according to the type and the site of the distal block. GAP type VI is replaced by Damato's pseudo-V. Two new types are proposed: in the first (type VII) the distal block is in the atrium and the proximal delay is in atrial miocardium proximal to stimulation site; in the second (type VIII), in subjects with pre-excitation, the block is in the accessory pathway and the proximal delay is in atrium.

Adolescent↗
PubMed1977

[Controlled multicentric trial of the antihypertensive agent indapamide].

Two-months' administration of 2.5 mg/day indapamide, preceded and followed by 2 weeks of a placebo, led to a significant fall in pressure values and normalisation of diastolic pressure in a high percentage of 47 subjects, mostly with essential hypertension, in a controlled multi-centre trial. Absence of toxic effects, tolerance and therapeutic activity at low doses recommend the drug for most cases of arterial hypertension.

Adult↗
PubMed1977

[Changes in myocardial metabolism during atrial pacing and catecholamine stimulation in normal subjects and patients with angina].

5 patients with angina had their threshold for angina evaluated by atrial pacing and by stimulation with catecholamine (dopamine). The authors then studied the metabolic changes induced by the two types of anginogenic load (AP and D-test) applied successively, and compared them with the post-ergometry ECG changes (lowering of the ST segment by at least 2 mm) and the findings on coronary arteriography (complete obstruction of at least 75% stenosis of a major branch vessel). The metabolic measurements were controlled against those of 5 normal subjects after standard ergometry. In the patients with angina, the AP test led to a constantly negative value for %. L. By contrast, the values of D(a-v)c and % O2 which were reduced in the normals, as indirect evidence of an increased coronary flow, remained practically static. During the dopamine infusion, although the % L was reduced, it remained essentially positive, while the D(a-v)c and % O2 were consistantly lowered.

Adult↗