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Biomedical subjects

G A Sutton

Publications and source records attributed to G A Sutton.

17 recordsLinked to original sources
PubMed2002

Clinical signs of West Nile virus encephalomyelitis in horses during the outbreak in Israel in 2000.

Between August and October 2000, 76 horses were reported by veterinary practitioners as having signs of a neurological disorder, varying from an involvement of the spinal cord alone to the entire central nervous system; 15 of the horses died or were euthanased as a result of their grave prognosis or secondary complications. At the same time, an outbreak of West Nile virus infection affected people and birds, principally domestic geese. West Nile virus was isolated from four of the horses with encephalomyelitis and five other horses seroconverted, indicating that the virus was the probable cause of the outbreak in horses. Three of the cases from which the virus was isolated are described briefly and one case is described in detail. This horse behaved abnormally and had general proprioceptive deficits in all four limbs. Its neurological condition deteriorated after two days and severe inspiratory dyspnoea due to a failure to abduct the arytenoids necessitated a tracheostomy. It died on the fourth day and histological lesions were observed in the brain stem and grey matter of the spinal cord.

Animals↗
PubMed2002

Osteoma of paranasal sinuses in a horse with inspiratory dyspnoea.

We describe a case of osteoma in the frontal and maxillary sinuses of a 3-year-old Arabian mare, presented due to an inspiratory dyspnoea. The mare underwent two surgical procedures in order to excise the tumour. Twelve months after admission the mare was healthy with no signs of respiratory abnormalities. Sinus radiographs and endoscopy repeated at that time revealed some regrowth of the tumour in the maxillary sinus, however, twenty-two months following surgery the mare did not show clinical signs of upper airway disease.

Animals↗
PubMed1999

[Equine Rhodococcus equi pneumonia: first report in Israel and its significance for man].

Rhodococcus equi is an important pathogen in young horses. In recent years it has been increasingly recognized as an opportunistic infectious agent in patients with immune deficiency. The increase in recognized cases may be related to the increased prevalence of AIDS. However, more cases may have been recognized lately due to increased awareness of the pathogenicity of this bacterium. Based on medical reports, there appears to be an association between Rhodococcus equi infections and exposure to animals, horses in particular. During the past year, 2 cases of rhodococcus pneumonia were diagnosed in foals in Israel. This information deserves the attention of the local medical community because of the zoonotic potential of Rhodococcus equi and the danger of its becoming more common. The climate in Israel is conducive to its growth and viability and since it flourishes in an environment with horses, the significant growth in our equine industry in recent years may contribute to an increase in Rhodococcus infections.

Actinomycetales Infections↗
PubMed1998

Pathogenesis and clinical signs of equine herpesvirus-1 in experimentally infected ponies in vivo.

Equine herpesvirus-1 (EHV-1) causes respiratory disease, neonatal death, abortion and neurologic disease. The main purpose of this study was to identify viral antigen in respiratory tract samples by immunoperoxidase staining. Six pony foals were selected on the basis of demonstrating seronegativity to EHV-1 by virus neutralization and housed in isolation. They were infected experimentally by administering EHV-1 nebulized ultrasonically through a face mask. Successful infection was clinically apparent as each of the foals had febrile responses, nasal discharge, and enlarged submandibular lymph nodes. Sporadic coughing was also heard. EHV-1 was isolated from nasopharyngeal swabs of 4/6 ponies and seroconversion was demonstrated in all foals. Bronchoscopic examination of the large airways revealed hyperemia. The incidence of recovery of Actinobacillus suis from nasopharyngeal swabs increased initially, with recovery of Streptococcus zooepidemicus isolates predominating at 3 wk post-infection. Cytology brushes were used to sequentially sample the respiratory tract of the infected ponies at the nasopharynx, mid-trachea and the mainstem bronchus. Bronchoalveolar lavage provided lung cells. Immunocytochemistry techniques were applied to both types of samples to locate EHV-1 antigen. Indirect immunoperoxidase staining of samples utilizing monoclonal antibodies specific for EHV-1 demonstrated viral antigen associated with cellular debris, primarily in the nasopharyngeal samples on days 3-9 post-infection.

Aerosols↗
PubMed1997

Study of the duration and distribution of equine influenza virus subtype 2 (H3N8) antigens in experimentally infected ponies in vivo.

The purpose of this experiment was to study the duration and distribution of equine influenza virus in actively infected ponies over a 3 wk period. Pony foals (6-8 mo old) were infected experimentally by nebulizing equine influenza subtype-2 virus ultrasonically through a face mask. Successful infection was clinically apparent as each of the foals (n = 6) had a febrile response, a deep hacking cough and mucopurulent nasal discharge for 7 to 10 d. The virus was isolated from nasopharyngeal swabs of all the ponies 3 and 5 d after infection and all the ponies seroconverted to the virus. Samples were taken from the nasopharynx, mid-trachea and the mainstem bronchus with cytology brushes through an endoscope as well as from bronchoalveolar lavage fluid. On days 3 to 7 post-infection, ciliacytophtorea (the presence of cilia and ciliated plates separated from columnar epithelial cells) was recognized on routine cytological stain. Indirect immunoperoxidase staining utilizing polyclonal antibodies demonstrated viral antigen in intact and fragmented ciliated epithelial cells and in fragments of ciliated plates. The infected cells and cell fragments were particularly evident on days 3 and 5 post-infection in the nasopharynx, mid-trachea and mainstem bronchus and on days 3 to 7 post-infection in the bronchoalveolar lavage samples. On days 7 and 21 post-infection, viral antigen was identified in vacuoles of alveolar macrophage-like cells collected by bronchoalveolar lavage. It can be concluded from this study that equine influenza virus can infect not only the upper airways but also the bronchial epithelium and that viral antigen can persist up to 21 d post-infection.

Animals↗
PubMed1989

Ptosis following cataract and trabeculectomy surgery.

A prospective study was carried out to estimate the incidence and severity of ptosis following cataract extraction and trabeculectomy. A postoperative ptosis of 2 mm or more was found in 6.2% of all cases. In this series the incidence of ptosis following surgery under local anaesthesia was greater than that under general anaesthesia. The aetiology and management of this complication are discussed.

Adult↗
PubMed1989

Recognising aponeurotic ptosis.

Thirteen patients who had ptosis surgery undertaken for disinsertion of the aponeurosis of the levator palpebrae superioris were reviewed. Pre-operatively all the patients had characteristic clinical signs of levator disinsertion which was confirmed at surgery and corrected by reposition of the disinserted aponeurosis. Five of these patients were initially mistakenly diagnosed as having a neurological cause for their ptosis. The diagnosis of this type of ptosis may easily be missed.

Blepharoptosis↗
PubMed1989

Intercapsular versus extracapsular cataract extraction.

Forty-five eyes that have undergone routine extracapsular cataract extraction with insertion of a posterior chamber intraocular lens were compared with a similar group of eyes that had undergone intercapsular extraction. Capsular fixation was more predictable following intercapsular (78%) than it was following extracapsular extraction (22%). Gonioscopy revealed prominence of the lens haptic in 22% of the intercapsular group, with peripheral anterior synechiae (PAS) in 18%; haptics were prominent in 78% of the extracapsular group, with synechiae in 55%. Lens eccentricity of 2 mm or more was seen in 2 patients (4%) following intercapsular and in 10 (22%) following extracapsular extraction. Pupil irregularities were noted in three of the intercapsular group (7%) and in eight of the extracapsular group, (13%) with peripheral iris tucking alone in three. These data strongly support the view that intercapsular is superior to extracapsular cataract surgery in terms of facilitating capsular fixation of posterior chamber intraocular lenses.

Aged↗
PubMed1989

Gonioscopic findings following insertion of Pearce Lasagap and Nova Curve Kratz posterior chamber intraocular lenses in extrapsular cataract extraction.

The gonioscopic appearances of 45 eyes that had undergone extracapsular cataract extraction with insertion of a Pearce Lasagap posterior chamber intraocular lens (group A) were compared with those of 45 eyes that had undergone the same procedure except for insertion of a Nova Curve Kratz posterior chamber lens (group B). Prominence of one or both loops was seen in 35 eyes (78%) of group A, with peripheral anterior synechiae (PAS) in 25 (55%). Prominence of one loop was seen in 14 eyes (31%) of group B, with PAS in 8 (18%) (P less than 0.001). Final visual acuity was comparable in both groups, 98% achieving 6/12 (20/40) or better. Although not statistically significant, the incidence of pigment dispersion, uveitis, discomfort and visual aberrations was greater in group A than in group B. We suggest that the apparent superiority of the Nova Curve Kratz lens in terms of the smaller incidence of loop prominence, as well as the reduced incidence of these other complications, is due to the fact that its haptic is inserted into the optic's edge rather than into the anterior surface of the lens optic, as is the case with the Lasagap lens.

Aged↗
PubMed1988

Analysis of the factors involved in cosmetic failure following excision of the eye.

We graded the overall cosmetic outcome of 56 patients who required excision of the eye. Each patient was then subjected to a more detailed analysis of the specific abnormalities associated with excision of the eye in order to discover which are associated most consistently with a poor cosmetic result. The only factor showing a statistically significant variation with the overall cosmetic outcome was the degree of upper lid sulcus. Taken individually the other features showed no statistically significant correlation. When each finding was scored, the averaged sum of the scores was related to cosmetic outcome with statistical significance. A method of quantifying orbital volume loss is described.

Adult↗
PubMed1980

Intraocular lens implantation by surgeons in training.

This paper is a retrospective study of 101 consecutive intraocular lens implantations with the Binkhorst 4 and 2-loop type lenses. The surgery represents a limited series of implant operations carried out by 10 surgeons of senior registrar grade on a programme of higher surgical training. When pre-existing adverse factors were excluded, the percentage of best visual results achieved was less than the best acuity levels reported by more experienced surgeons. The incidence of complications which could be related to surgical factors was found to be higher.

Education, Medical, Graduate↗
PubMed1980

Histopathological changes after pseudophakos.

Cataract extraction and iris clip lens implantation in an 88-year-old woman were followed by hyphaema, anterior uveitis and organised exudates around the implant. The globe was enucleated after 15 months due to pain and a poor visual prognosis. Sections showed an epithelial downgrowth into part of the anterior chamber, associated with a fibrous membrane which had surrounded part of one loop of the implant. Atrophy of the iris, adenomatous changes in a ciliary process and an after-cataractous ring were noted. Inflammatory changes were present in the uvea, associated posteriorly with degenerative choroido-retinitis, probably of arteriosclerotic origin. The nylon loops of the implant showed areas of biodegradation and were partly fibrosed in. The possible relationship of the various changes is discussed.

Aged↗
PubMed1979

Use of electroacoustic localisation in the management of intraocular foreign bodies.

A new model of the electroacoustic discriminator and localiser has been put into production, and this paper reports on the preproduction model during its trial period in the management of patients with intraocular foreign bodies. Its particular advantage in localisation at the time of surgery and the procedure for using it are described. The visual results following surgical extraction of 17 cases of magnetic foreign bodies in the posterior segment are outlined.

Eye Foreign Bodies↗