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Biomedical subjects

G A Scott

Publications and source records attributed to G A Scott.

26 records · Page 2Linked to original sources
PubMed1989

Development of human fetal skin transplanted to the nude mouse.

Thirty-five human fetal skin (HFS) grafts were transplanted to nude mice for 7 to 70 d and evaluated histologically with 64 biopsies. The estimated gestational ages (EGA) of the grafts at the time of the transplantation ranged from 8 to 19 weeks. The maturation of the engrafted fetal skin was evaluated by assessing epidermal, dermal, and appendage development. Within the nude mouse, the HFS demonstrated progression in stratification and maturation of the epidermis. The dermis increased in depth, adding fibrovascular stroma and adipose tissue. The appendages demonstrated invagination, differentiation, and progression of organogenesis. Subcutaneously placed grafts showed the same rate of HFS development as HFS in utero. The grafts transplanted to the surface of the nude mice and exposed to air demonstrated an acceleration of development. We conclude that HFS transplanted to the nude mouse is an effective in vivo model for maintaining and altering HFS maturation.

Animals↗
PubMed1988

Spindle cell hemangioendothelioma. Report of seven additional cases of a recently described vascular neoplasm.

Seven cases of spindle cell hemangioendothelioma, a recently described vascular neoplasm, are presented. The lesions were multiple in five of the seven cases and primarily involved the upper extremities, particularly the fingers. On microscopical examination, the tumors were composed of two elements: cavernous spaces and spindled cells. In addition, clusters of histiocytoid endothelial cells, some with intracytoplasmic vacuoles, were present. The clinical behavior is marked by numerous local recurrences and slow but steady progression of the disease.

Adolescent↗
PubMed1986

Combined posterior incision and arthroscopic intra-articular repair of the meniscus. An examination of factors affecting healing.

Using intra-articular techniques for meniscal repair, several factors associated with meniscal lesions were analyzed prospectively to determine their effects on healing of the repair. Although 260 medial or lateral meniscal repairs in 240 patients were done, 178 repairs in the 167 patients who were followed by postoperative arthroscopy or arthrography form the basis of this study. The results of the repairs were classified as healed, incompletely healed, or not healed. The average duration of follow-up was 100 weeks (range, twenty-eight to 231 weeks). By arthrographic or arthroscopic criteria, 61.8 per cent of the menisci healed, 16.9 per cent healed incompletely, and 21.3 per cent did not heal. Ninety-two per cent of the menisci were categorized as clinically stable, and 80 per cent of the patients returned to active sports participation. Positive correlations with healing were found in patients who had a narrow peripheral meniscal rim (zero to two millimeters) (p = 0.03) and in patients who had a repair that was associated with reconstruction of the anterior cruciate ligament (p = 0.0001).

Adolescent↗
PubMed1964

Acute silicosis.

Explore the source record for details and available documents.

Aged↗
PubMedDate not supplied

Coexistence of incontinentia pigmenti and neonatal herpes simplex virus infection.

We present a female infant with classic clinical and histologic features of stage I incontinentia pigmenti with coexistent neonatal herpes simplex virus infection. The diagnosis of a heritable cutaneous condition does not exclude the possibility of a coexistent infection and, given the similar clinical presentation of neonatal vesicular eruptions, accurate diagnoses may require skin biopsy and culture.

Diagnosis, Differential↗