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Biomedical subjects

G A Pankey

Publications and source records attributed to G A Pankey.

81 records · Page 5Linked to original sources
PubMedDate not supplied

Multicenter, phase IV evaluation of intravenous ciprofloxacin as initial therapy in patients with lower respiratory tract, urinary tract, and skin/skin structure infections.

A prospective, open-label, multicenter, Phase IV study of the efficacy and safety of intravenous (IV) ciprofloxacin (400 mg by 60-minute infusion every 12 hours) in the treatment of lower respiratory tract infections (LRTIs), urinary tract infections (UTIs), and skin/skin structure infections (SSSIs) in hospitalized patients was conducted in 1991. After a minimum of 3 days of IV therapy, patients could be switched to oral therapy with any antimicrobial. Of 360 patients who were valid for investigator assessment of clinical outcome at the end of IV therapy, a favorable outcome (cure and improvement in infection) was reported in 337 (94%) patients and failure was reported in 23 (6%) patients. Of 330 patients valid for investigation assessment of clinical outcome at the end of all therapy (IV treatment alone or IV treatment followed by an oral antimicrobial), a favorable outcome was noted in 311 (94%) patients, and failure occurred in 19 (6%) patients. Adverse events were noted in 72 (9%) of 782 patients and led to premature discontinuation of IV therapy in 23 (3%) patients. IV ciprofloxacin appears to be effective and safe in the management of mild-to-moderate LRTI and SSSI and mild, moderate, or severe UTI in hospitalized patients.

Adult↗
PubMedDate not supplied

A comparative study of bacampicillin hydrochloride, penicillin V, and amoxicillin in the treatment of acute tonsillitis and/or pharyngitis due to beta-hemolytic streptococci.

Fifty-five outpatients with acute tonsillitis and/or pharyngitis due to group A beta-hemolytic streptococci were treated during 1978 and 1979. Twenty-nine patients received 400 mg of bacampicillin twice a day, 21 patients received 250 mg of penicillin V four times a day, and five patients received 250 mg of amoxicillin every 8 hr. All except one patient, who was treated with bacampicillin, had a satisfactory clinical response to treatment. The bacteriologic response was satisfactory in all but one patient. None of the 55 patients developed adverse effects that necessitated the discontinuance of the antibiotic in use. No significant differences were found between the clinical or the bacteriologic responses to bacampicillin, penicillin V, or amoxicillin (Fisher's exact test).

Acute Disease↗
PubMedDate not supplied

Clinical usefulness of amikacin and doxycycline in the treatment of infection due to Mycobacterium fortuitum and Mycobacterium chelonei.

The antimicrobial agents amikacin and doxycycline, which are not conventionally considered for use in treatment of mycobacterial infections, inhibit growth of Mycobacterium fortuitum and Mycobacterium chelonei in vitro. Ten patients were treated with these drugs alone or in combination with some surgical procedure. Seven of the 10 patients were definitely cured by the therapy. Only one definite treatment failure occurred. Patients with infections due to M. fortuitum or M. chelonei that are susceptible in vitro to these drugs appear to benefit from chemotherapy.

Adult↗
PubMedDate not supplied

Diagnosis of disseminated cytomegalovirus infection and pneumonitis in a heart transplant recipient by skin biopsy: case report.

A pulmonary infection caused by both Toxoplasma gondii and cytomegalovirus (CMV) developed in a heart transplant recipient. A presumptive diagnosis of CMV pneumonitis was made on the basis of a skin biopsy finding demonstrating CMV inclusions. This diagnosis was later supported by a positive pleural fluid culture for CMV, a greater than fourfold increase in CMV IgG antibody, and a response to therapy with ganciclovir sodium. Biopsy of skin lesions in patients at risk for CMV infections may represent an important early diagnostic tool.

Adult↗