Biomedical subjects
G A Marcel
Publications and source records attributed to G A Marcel.
[Red cell filterability, smoking and cardiovascular risk factors (author's transl)].
Red cell deformability, which allows cells of 7 mu diameter to flow through capillaries not larger than 3 mu, can be approached by the measure of blood filterability on nuclepore 5 mu filters. Filterability is reduced in arterial diseases. We have, in 72 patients, correlated red cell filterability, with the number of cardiovascular risk factors present high blood pressure, overweight, diabetes, hyperuricemia, hyperlipemia smoking). There is a statistical difference between groups with risk factors present as a whole and with O risk factor (p less than 0.01). The difference is highly significant between O and 4 risk factors (p less than 0.0005). Filterability decrease is also directly correlated with the number of cigarettes smoked per day (less than 0.05) and decrease is enhanced by smoking two cigarettes.
Red cell deformability: physiological, clinical and pharmacological aspects.
Twenty five thousand billions of red cells circulate through 300 miles of capillary network. The red cell diameter is 7 to 8 microns and the capillary diameter 3 to 5 micron. Red cells deformability is therefore an essential condition for survival. It is impaired in a certain number of clinical conditions. A French task force, covering 40 University Hospitals, is presently investigating the clinical implications of red cell filterability, and its possible therapeutical consequences.
[Filtrability of preserved blood].
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[Letter: Thrombolitic drugs].
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[Contraceptive agents and thrombosis].
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High prekallikrein levels during pregnancy.
Prekallikrein levels are significantly increased during pregnancy. The increase is neither due to an excess of Hageman factor or of an activator, nor to the decrease of an inhibitor.