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Biomedical subjects

G A Harrison

Publications and source records attributed to G A Harrison.

At least 91 records · Page 5Linked to original sources

A survey of successful FFARACS candidates in Australasia.

As of October 1985, 37 candidates have passed the final examination in intensive care for the Diploma of Fellow of the Faculty of Anaesthetists, Royal Australasian College of Surgeons (FFARACS). In September 1984, 23 of these successful candidates responded to a questionnaire seeking information on their educational experiences during training and the nature of their work since the examination. At that time, six were staff specialists in anesthetic practice, one was involved in full-time intensive care research, one was the director of an accident and emergency center, and the remaining 15 were full-time staff specialists or senior registrars in intensive care. The responses to the questions on training indicated that more intensive care and medical experience were considered desirable. Most felt that their training and the examination were useful in determining long-term employment, satisfactory performance in intensive care, and personal job satisfaction.

Adult↗

Sodium bicarbonate and alfalfa hay additions to wheat silage diets fed to lactating dairy cows.

Two experiments were conducted to examine dietary effects of .8% sodium bicarbonate and 1.4 kg/d of alfalfa hay on performance and rumen metabolism of lactating dairy cows fed 50% wheat silage and 50% concentrate (dry basis). In Experiment 1 with 12 midlactation Holsteins in a 4 X 4 Latin square design, intake, milk production, and milk composition were not affected by treatment. Dietary sodium bicarbonate and alfalfa hay did not alter blood, rumen, or fecal pH. Rumen volatile fatty acid pattern was not affected by sodium bicarbonate, but addition of hay resulted in higher molar percentage propionate and lower acetate: propionate ratios. In Experiment 2 with 32 early lactation cows (20 Holsteins and 12 Jerseys) in a complete randomized block design, supplementation of sodium bicarbonate, alfalfa hay, or both did not affect intake, milk production, or milk composition in the first 8 wk of lactation. Blood, rumen, and fecal pH were not affected by treatment. Dietary sodium bicarbonate did not alter ruminal volatile fatty acid profile, whereas addition of hay increased molar proportion acetate and decreased molar proportion butyrate. A shift in rumen fermentation was observed across treatments from wk 1 through 8 postpartum with molar proportions of acetate and butyrate increasing and molar proportion of propionate decreasing.

Animal Feed↗

Resistance in oral streptococci after repeated three-dose erythromycin prophylaxis.

Ten healthy volunteers, from whom no erythromycin-resistant oral streptococci could be isolated initially, received three doses of erythromycin stearate (1.0, 0.5 and 0.5 g) on two separate occasions with a one-week interval between them. After the second administration all volunteers yielded moderately resistant strains (MIC 1-4 mg/l) and four harboured highly resistant streptococci (MIC 16- greater than 256 mg; MBC 128- greater than 256 mg/l). Erythromycin-resistant strains persisted in eight of the volunteers at 23 weeks and in five of eight volunteers at 43 weeks. Species included Streptococcus sanguis, Str. mitior and unclassified streptococci, and dextran-positive strains were encountered. Erythromycin-resistant streptococci are thus readily selected by two administrations of the three-dose regimen. Until the time of emergence of the resistant strains is further clarified a full assessment of the antibiotic sensitivity of the flora of the gingival sulcus is advisable before erythromycin prophylaxis is repeated.

Drug Resistance, Microbial↗

Resistance in oral streptococci after repetition of a single-dose amoxycillin prophylactic regimen.

Ten healthy volunteers received 3 g amoxycillin each week for up to four weeks. One volunteer carried streptococci resistant to amoxycillin in small numbers before the first dose was administered. After one administration of amoxycillin, this volunteer and one other yielded streptococci resistant to 1 mg/l amoxycillin on direct culture of dental plaque; after two administrations, resistant streptococci were detected in one further volunteer; and a total of six volunteers yielded resistant streptococci after the fourth week of amoxycillin administration. Repeated use of the single-dose prophylactic regimen encourages the emergence of streptococci considerably more resistant to amoxycillin than those generally encountered in the oral cavity, but the clinical significance of these results is uncertain as the peak serum concentrations of amoxycillin achieved after a 3 g oral dose for prophylaxis exceed the minimum bactericidal concentrations of amoxycillin for these strains.

Amoxicillin↗

Stress, catecholamines, and sleep.

Difficulties in defining stress stem from its subjective nature. Measurements of stress based on its effects on physical and mental morbidity tend to be speculative because of the multifactorial causation of stress-related diseases, and the characteristically long time-lag between stress states and morbidity. In this study catecholamine output was measured in a group of adults Oxfordshire villagers and the observed variations were related to their lifestyles and health perceptions. A marked circadian variation was observed with adrenaline showing the most marked associations with lifestyle. In men it was possible to account for a relatively high proportion of the variation in adrenaline excretion by relating values to certain factors associated with stress. In women there appears to be a similar association between adrenaline output and the social class of the husband. Data were also obtained on sleep characteristics, which were assessed with regard to lifestyle. Very broadly, sleep duration is related to the level of waking activity, while sleep latency and quality are correlated with people's self-perception of health.

Adolescent↗

Pathology tests.

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Hospital Departments↗

Deep neck infection complicated by diabetes mellitus. Report of a case.

A poorly controlled diabetic patient who developed a life-threatening deep neck infection from a periodontal abscess is presented. Despite treatment reflecting the current surgical and medical approach to management of this infection, he failed to show the consistent improvement that would be expected in a nondiabetic patient. The physiologic differences in the defense systems of the diabetic versus the nondiabetic host are discussed, and general guidelines for identification of the diabetic patient are offered.

Diabetes Mellitus↗

Technical aspects of bronchopulmonary lavage for alveolar proteinosis: two case reports.

Under general anaesthesia, therapeutic bronchopulmonary lavage was performed in two patients suffering from alveolar proteinosis. In one patient, difficulties were experienced during attempted lavage of the right lung. Fluid trapping occurred when saline was infused down the tracheal (right) lumen of a Carlen's double lumen endobronchial tube and also when a left Robertshaw tube was similarly used. Spillover of saline into the left lung occurred when a right Robertshaw was used. Efficient lavage of the right lung could only be performed after insertion of a White endobronchial tube. In the second patient, both lungs were washed without problem using a left Robertshaw tube after difficulty had been experienced with a Carlen's tube. In both cases venous admixture was least when the lavaged lung was filled with saline. Hypoxaemia increased as the lung was drained. Details of technique are discussed as are problems with double lumen endobronchial tubes used during the procedure.

Adult↗