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Biomedical subjects

G A Hall

Publications and source records attributed to G A Hall.

At least 73 records · Page 4Linked to original sources
PubMed1975

An ultrastructural and biochemical study of hexachlorophane-induced fatty liver in sheep.

The administration of single or multiple oral doses of hexachlorophane to yearling sheep resulted in a periportal fatty liver. The accumulation of fat is accompanied by ultrastructural changes in the hepatocyte organelles, particularly the endoplasmic reticulum and Golgi apparatus, and by decreased serum lipid and triglyceride levels. It is suggested that an impairment in the triglyceride secretory mechanism of the liver cell may be the patho-physiological basis for fatty liver. However, the changes in the liver were not accompanied by an evidence of significant impairment of liver cell function.

Alcohol Oxidoreductases↗
PubMed1975

A comparative study of liver changes produced by inoculating pregnant rats with Salmonella dublin or with its endotoxin.

Rats were inoculated with viable Salmonella cublin organisms or a crude Salm. dublin endotoxin at the 14th day of pregnancy. They were killed at intervals up to 96 h after inoculation and the pathogenesis of the liver lesions compared. The immediate effects on the liver of both inoculations were the same but there were differences in the later stages. In the endotoxin inoculated rats the initial liver lesions regressed but in the bacteria inoculated rats fat accumulated in the periportal and mid-lobular areas as the initial lesions regressed, and there was nuclear enlargement and mitosis. These lesions may represent the response of the liver to a continued bacteriaemia and endotoxaemia originating from the uterine lumen.

Animals↗
PubMed1974

An investigation into the mechanism of placental damage in rats inoculated with Salmonella dublin.

Rats were inoculated with viable Salmonella dublin organisms, or a crude S dublin endotoxin, at the fourteenth and nineteenth days of pregnancy. They were killed at intervals up to 96 hours after inoculation, and the pathogenesis of the lesions was compared. At each stage of pregnancy the initial lesions produced by live bacteria and crude endotoxin showed important similarities, confirming the significance of endotoxin in the pathogenesis of placental damage. There were differences in the later stages of the pathogenic process. Comparisons of the process of placental damage at the two stages of pregnancy have suggested that the same mechanism acts throughout the last third of pregnancy and that thrombosis and disseminated intravascular coagulation are not an important part of the mechanism of placental damage.

Animals↗
PubMed1973

Changes in the rat placenta following inoculation with Salmonella dublin.

The intraperitoneal inoculation of a suspension of Salmonella dublin (2.9 x 10(8) viable organisms) into thirteenth to fourteenth day pregnant rats produced reproductive failure. Rats were killed 6, 12, 18, 24, 48, 72, 96 and 120 hours after inoculation, and the pathogenesis of the lesions studied. The lesions progressed through four stages, starting with severe congestion of the placenta which developed rapidly and caused distortion of the labyrinth and sometimes resulted in hemorrhage onto the surface of the placental disc. Hemorrhage and necrosis in the decidua basalis produced placental detachment; subsequently, there developed an acute necrotizing inflammation of the placental sites which was followed by proliferation of granulation tissue. The initial lesions showed many similarities with those produced in rat and mouse placentas by endotoxins of gram-negative bacteria, indicating that the basic lesion produced in the placenta by endotoxin is slowing and stasis of the placental circulation.

Abortion, Veterinary↗