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Biomedical subjects

G A Galil-Ogly

Publications and source records attributed to G A Galil-Ogly.

At least 19 recordsLinked to original sources
PubMed2005

[Monoclonal antibody therapy with mabtera of patients with b-cell low grade non-Hodgkin's lymphoma].

The data on monoclonal antibody monotherapy (mabtera, rituximab) in 44 patients with B-cell low grade non-Hodgkin's lymphoma were assessed. Thirty-four of them had received several courses of second- or third line chemotherapy: mabtera was used as first-line therapy in 10. Mabtera was administered in a dose of 375 mg/m2 body surface, once a week, by slow intravenous infusion, 4-14 times depending on effect. Each relapsing patient received, on the average, 4 infusions, while each refractory one--8 weekly infusions. Overall response in the first group was 44%. Median overall relapse-free survival was 9 months. Apparenti effect of treatment was reported in 50% of primary patients (median overall relapse-free survival--15 months). Therapy was well tolerated. Fever and shivering stage I and II were among the most frequent post-infusion effects. High level of CD-20+B-lymphocytes should be used as prognostic indicator for effectiveness of therapy.

Adult↗
PubMed2002

[Cytologic differential diagnosis of various peripheral lung cancers].

The data on 25 cases of histologically verified bronchioloalveolar carcinoma and papillary adenocarcinoma are discussed. Reliable differential diagnostic cytological features of both diseases were established using a statistical, program and fine-needle biopsy findings. Statistical analysis data pointed to the sets of cytological features: "serial pattern--clear cell boundaries" and "serial pattern--presence of macrovacuoles" as a major factor of accuracy of bronchiolo-alveolar carcinoma and papillary adenocarcinoma diagnosis. These cytological features may be used for reliable diagnosis of the diseases.

Adenocarcinoma, Papillary↗
PubMed2000

[Role of induction chemo- and radiotherapy in the treatment of locally advance breast cancer].

336 patients with locally-advanced breast cancer underwent neoadjuvant chemotherapy or chemoradiotherapy. Increase in T- and N-indices (change of stage after neoadjuvant chemotherapy) proved an important prognostic factor. Survival rates correlated with clinical effect and dropped as it diminished. This tendency was clear in both groups. There was no relationship between stage and overall and disease-free survival rates at early stages but later they declined as T- and N-indices decreased.

Adult↗
PubMed2000

[Correlation of clinical effect, pathological response of tumor cells and the end results of combined treatment of locally advanced breast cancer].

A correlation was established between the end-results of neoadjuvant chemotherapy for locally-advanced breast cancer and pathological response of tumor cells. Also, the end-results correlated with CR or PR and pathological response. Only a small proportion of patients with tumor progression were registered as stage III or IV of pathological response (0.6 and 0.8%, respectively).

Adult↗
PubMed1999

[Computerized tomography of solitary lung metastasis].

Experience has pointed to a rather low potential of traditional procedures of roentgenography and tomography in detecting small foci (ca. 4-5 cm in dia.). Metastases are often not seen in the shadow of the ribs, diaphragm and cardio-vascular complex. X-ray computed tomography (CT) is a method of choice for early diagnosis and further tracking tumor process in the lung. Superior spatial resolution offers complete summation-free visualization of the lung parenchyma. Provision of more data, including information on "occult" pathology in the lung, is instrumental in confirming or rejecting diagnosis of solitary tumor.

Adult↗
PubMed1999

[Results of combined treatment of patients with rectal cancer using a single preoperative radiotherapy dose of 7.5 Gy].

The results of 3-year combined and surgical treatment of 173 patients with rectal tumors are discussed. Single dose of 7.5 Gy was administered to 83 patients on the eve of radical surgery. Ninety patients in control received radical surgery alone. One-, two- and three-year radical cure rates in the study group were higher by 22.9, 21.2 and 29.3%, respectively, while 3-year recurrence-free survival in the same group was 2.7 times that in the surgical patients.

Adult↗
PubMed1999

[Current diagnosis and combined and radiation therapy of pancreato-biliary cancer in patients with jaundice].

The effectiveness of therapy of pancreato-biliary cancer in jaundice patients has been raised due to introduction of sparing slightly-invasive (percutaneous, transhepatic) procedures for suppression of choleostasis and restoring biliary return to intestine. Also, such measures as pancreato-digestive anastomosis, radical surgery to compensate jaundice-related functional and morphological disorders and changes in the liver as well as perfection of procedures of combined and radiation therapy were used.

Adult↗
PubMed1999

[Treatment for squamous cell carcinoma of the trachea].

Treatment of squamous-cell tracheal tumors was given to 85 patients. Surgery was carried out in 48 (56.5%), radical resection--22 (25.9%). Distant metastases detected preoperatively in 19 (22.4%) patients were an absolute contraindication for radical surgery. Combined therapy was received by 14 cases without any grave postoperative complications. Three- and five-year survival after combined and surgical treatment was 59.9 +/- 10.5 and 40.9 +/- 10.5%, respectively. Radiation was given to 48 (56.5%) patients. This group included 26 cases of palliative operations and exploratory laparatomy. Three- and five-year survival after radiation was 30.1 +/- 6.7 and 27.6 +/- 6.7%, respectively.

Adult↗
PubMed1999

[Radiotherapy for cystadenoma of the trachea].

Radiation as a method of treatment was carried out in 16 (25.0%) out of 64 patients with tracheal adenocystoma (radical dosage of 50-70 Gy (12) and palliative--40-48 Gy (4). The dosimetric profile consisted of the cervical, cervico-thoracic, thoracic and bifurcation sections of the trachea. Complete resorption of tumor was registered in 12, partial--3, no effect in 1 cases. Three-, five- and ten-year survival was 65.2 +/- 12.6; 55.9 +/- 13.5 and 10.4 +/- 13.1%, respectively.

Adult↗
PubMed1999

[Lung cancer: 30-year experience of surgical and combined treatment].

6,212 lung cancer patients have been examined and treated. The data on surgical and combined treatment of 2,702 patients have been analyzed. Postoperative complication incidence has dropped to 5.4% in recent years. End results have improved due to use of organ-saving, reconstructive and plastic procedures for the bronchi and trachea in conjunction with radiotherapy.

Adult↗
PubMed1996

[The grouping of morphological variants of non-Hodgkin's lymphomas (lymphosarcomas) by the degree of malignancy].

The authors stated that WHO classification allows identification of two groups of morphological variants of non-Hodgkin's lymphomas: low- and high-grade malignancy. These differ by principal clinical characteristics, incidence of complete and partial remissions, survival duration. The analysis of clinical course, long-term and short-term treatment outcomes is provided for 674 patients with the above lymphomas.

Adolescent↗
PubMed1996

[Early peripheral cancer of the lung: long-term results of combined therapy using sparing resection techniques].

Two hundred-thirty patients were operated on for peripheral lung cancer TIN0M0 in 1960-1990. Pheumonectory was performed in 3 cases, lobectomy-123, segmentectomy-40, wedge-like resection-57 and removal of tumor-in 7 cases. Limited resection in 20 patients was not followed by radiation therapy, Radiation treatment was given to 15 patients preoperatively, 53-postoperatively and 16 patients-pre-and postoperatively, Five-year survival after combined treatment was recorded in 70.5%, while without this treatment-68.7%. Local recurrences following limited intervention were usually detected 3-5 years later, regional and distant metastases developing within the first 24 months. A reverse correlation was established between extent of surgery and local recurrence incidence. Reoperation such as lobectomy or pneumonectomy is feasible in cases of timely diagnosis. The highest 5-year survival rates were registered for segmentectomies carried out in combination with postoperative radiotherapy (77.2%). Prognosis proved best in cases of adenocarcinoma and tumor arising in the cicatrix. Paliative surgery appeared preferable for primary tumor 1.5 cm in diameter and less. Even in small-size malignancy, removal of tumor is not radical enough, Wedge-like resection is admissible in small-size subpleural lesions only. Preoperative radiotherapy results proved inferior to those of other procedures of combined treatment. Pronounced radiation-induced pneumonitis involving re-hospitalization for symptomatic treatment occurred in 7 (5.5%) cases of lobectomy combined with radiotherapy and in 2 (1.9%) cases of limited resection.

Humans↗
PubMed1995

[Multiple primary malignant neoplasms and survival of patients with stage-I lung cancer].

The study group included 2161 patients operated on in 1968-1990. Tumors stage I were morphologically confirmed in 910 cases (T1S-3, T1-375 and T2-532). 827 patients survived 5 years (90.9%); 551 patients-10 years (60.3%). Primary multiple neoplasms (PMN) of different localization were detected in 96 (10.6%) patients with stage I tumors. Thirteen patients (13.5%) died of progression of a second tumor; 17 (17%)-of other causes. Average 5-year survival was 65%, 10 years-53%. These indices in 96 patients with PMNs were 73 and 53%, respectively. Relative risk of PMN in lung cancer was found to be in direct correlation with survival time and to depend, to a large degree, on tumor extension. When PMNs are detected early and treated radically, new primary tumors emergence does not significantly in lung cancer stage I. Preliminary results showed chemotherapy (neoadjuvant one included) to lower the risk of PMN in lung cancer stage I. The most plausible causes of enhanced survival of patients with PMNs are discussed.

Female↗
PubMed1992

[The preoperative morphological diagnosis of hepatobiliary and pancreatoduodenal cancer].

Morphological investigations at the preoperative stage were performed in 94 patients. The morphological diagnosis was made on the basis of findings of duodenal biopsies, cytological investigations of the bile and aspirate from the Vater's papilla ampulla, endocholedochal and percutaneous biopsies with the express cytological monitoring. Recommendations are given on the programs of preoperative morphological diagnosis of carcinoma of Vater's papilla.

Adult↗