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Biomedical subjects

G A Frank

Publications and source records attributed to G A Frank.

At least 19 recordsLinked to original sources
PubMed1992

[The immunohistochemical study of trophoblast beta 1-globulin expression in cancer and in the mucosa of the large intestine].

The expression of pregnancy-specific beta-1-globulin (SP1) was studied in cancer-affected and nonaffected colon mucosa. The antigen was revealed in 19 out of 50 (38%) cases of carcinoma and in 1 out of 4 cases of ulcerative colitis. SP1 was found neither in noncancer colon mucosa nor in transitional mucosa and adenomas. The antigen was detected in the epithelium and stromal macrophages of carcinoma. SP1-positive cells were located mainly in the sites of tumor invasion. The results allow considering SP1 the tumor marker suitable for immunohistochemical diagnosis of colon cancer.

Adenocarcinoma↗
PubMed1992

[Morphological diagnosis and prognosis in early ductal breast cancer].

One hundred and ten cases of precancer and early ductal breast cancer were analysed. Patterns of non-invasive ductal cancer were identified. Multicentric growth was observed in 55.8% of patients with intraductal cancer and invasive ductal cancer with predominant intraductal component. Early ductal cancer proved to have favorable prognosis, with only 2.2% of patients with disseminated tumor and 4.4% of those with recurrence identified during the mean follow-up period of 53.5 months.

Adult↗
PubMed1992

[The potentials for the organ-preserving treatment of early stomach cancer].

The oncological substantiation of endoscopic and economical surgical treatment of T1N0-1M0 gastric carcinoma in 46 patients was appraised. The results were studied with due regard for the peculiarities of early gastric carcinoma (EGC) revealed in 290 patients after standard surgical management. It was established that organ-preserving treatment of ECG is possible--5-years survival was 96.2%. Endoscopic removal can be considered radical only in T1P1 tumors without invasion of the lymphatic vessels of the wall and was of a multistage character in 86.2% of cases. Careful surveillance after its completion is necessary. Surgical treatment in indicated in repeated recurrences; they were encountered in 44.8% of cases. The causes of the recurrences were noncoincidence of the macroscopic and histological boundaries of the tumor (33.6%), multicentric growth (30.4%), and invasion of the submucosa. Metastases are encountered in the lymph nodes in 9.1% of cases in economical treatment. In T1N0-1M0P1-2 carcinoma, absence of multicentric growth, and III degree dysplasia in the surrounding mucosa (reflecting increased risk of multicentric growth) the volume of organ resection may be limited on condition that P1 lymphadenectomy is performed. The results of organ-preserving treatment are comparable with those of surgical treatment conducted in a standard volume.

Adenoma↗
PubMed1992

[Monoclonal antibodies to neuron-specific enolase in phenotyping lung cancer].

Morphological assessment of two samples of monoclonal antibodies (mcAB) to gamma-unit of neurospecific human enolase (NSE) is performed. It is established that mcABs interact in the tissue sections with neurons of the brain and spinal cord, gangliocytes of the central and peripheral nervous system this proving their specificity. 56 cases of lung carcinoma are studied using these mcABs; endocrine carcinoma was found in 11 cases, nonendocrine--in 45 cases. Neuroendocrine differentiation is revealed in 8 of 45 cases of non-small cell carcinoma; in all observations of small cell carcinoma NSE was found.

Antibodies, Monoclonal↗
PubMed1992

[Morphometric parameters of malignant cells in non-leukemic hemoblastosis with primary lymph node involvement].

Morphometric studies were conducted to distinguish reactive and malignant lymphoid processes and to obtain a more objective and reproducible grading system for non-Hodgkin's lymphomas (NHL). Twenty-three untreated patients (3 with reactive lymphadenitis, 2 with diffuse lymphomas, 18 with lymphosarcomas) were studied. The sections of lymph nodes were stained with 50% aqueous silver nitrate solution and then counter-stained with methylene blue. MOP-Videoplan (Reichert, Austria) image analyzer was used for morphometry. The size and shape of nucleus, number and position of nucleoli and the number of silver grains (K1) and relative size (K2) of each grain were investigated. The computer classification of lymphoid cells based on a stepwise linear discriminant analysis resulted in 63% correctly classified cells. Among seven most discriminating parameters, the nucleoli area and the number and size of silver grains demonstrated the highest correlation with malignancy. The data obtained have evidenced that nucleolar parameters can be applied to computer classification of lymphoid neoplastic cells and for objective grading of NHL.

Adolescent↗
PubMed1991

[The morphology of the regional lymph nodes in skin melanoma].

Morphometric analysis was used to study the architectonics of hyperplastic regional lymph nodes in malignant melanoma patients as offset by normal condition. Specific volume relationships between all basic structures of the organ were established practically in all study groups. The specific features established should be continued at morphologic examination of lymph nodes for skin melanoma diagnosis.

Axilla↗
PubMed1991

[Immunohistochemical study of meconial antigens in neoplasms and mucosa of the colon and rectum].

The expression of 4 meconial antigens--beta-1-MA, beta-2-MA, MMA, gamma-MA in neoplastic and preneoplastic colonic mucosa was studied. Meconial antigens were revealed in small amount in adult normal colonic epithelium. The mucosa adjacent to tumours was rich in these antigens. Cellular localization of meconial antigens in these parts of colonic mucosa was similar to that of embryonal alimentary tract. beta-1-MA was found in 96%, beta-2-MA--73.6%, MMA--82.8%, gamma-MA--31.8% of colonic carcinomas.

Antigens↗
PubMed1991

[The histological characteristics of human lung tumor transplants growing under the renal capsule of mice in an immunodepressed state].

In order to determine the prognostic value of a "subcapsular test" in assessment of individual sensitivity of lung tumors to antitumor action, research was conducted into the histological structure of 18 human lung tumors and 110 grafts of these tumors, which had grown within 6 days under the renal capsule in mice under the immunosuppressed condition, caused by whole-body irradiation. The presence of necrosis in an original tumor led to connective tissue growth in grafts. The stroma/parenchyma ratio in grafts was increased as compared to original tumors. Lymphoid infiltration in 6-day grafts was, as a rule, unmarked. In 2 of 18 cases histotypes of a primary tumor and its grafts differed, i. e. the "subcapsular test" could be used to detect latent polymorphism of lung tumors. Correct prognosis of an individual response of human lung tumors to antitumor action with the "subcapsular test" also necessitated histological verification of the results.

Animals↗
PubMed1990

[Chemotherapeutic pathomorphosis of breast cancer].

Features of pathomorphism of mammary carcinoma were studied in 177 women after a course of drug therapy. Qualitative and quantitative morphologic changes in the tumor were poorly manifest: they were detected in only 54 percent of patients and only in 9 percent the effect was manifest (third-fourth stage of involvement). Characteristic findings here were augmentation of cellular dystrophy, necrotic changes, enhanced nuclear polymorphism; significant injury to tumor parenchyma was paralleled by development of xanthomatosis foci and lymphoid histiocytic infiltration.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1978

[Morphogenesis of dysplasia and lobular cancer of the breast].

During the recent ten-year period lobular cancer of the mammary gland arrests special interest. It is characterized by a specific clinical course, frequent bilateral involvement of the glands, multicentric and manifest invasive growth without any noticeable signs of destruction of the pre-existing glandular tissue. This cancer is preceded by carcinoma in situ. In the paper, the necessity is substantiated to differentiate this kind of cancer as a special nosological unit, its peculiar structure being described. Besides the classical form of the growth from small homologous cells like chains, also there was found a special form of the growth as alveolar structures consisting of light pagetoid cells. The initial stages of lobular cancer growth are described both against the background of carcinoma in situ and avoiding it from dysplasia. Attention is given to a tendency of this cancer to mucicarminophilia, a frequent association with mucous cancer, the data speaking in favour of its myoepithelial origin are reported. It is emphasized that carcinoma in situ may give rise both to lobular (myoepithelial origin) and other forms of cancer.

Breast Neoplasms↗
PubMed1977

[Changes in several properties of transplantable adenocarcinoma of the large intestine during passage].

In the course of serial passages of adenocarcinoma (AKTOL), arising from fetal colonic tissues which underwent spontaneous malignization after being grafted to syngeneic adult mice, there was an increase in the rate of growth of the subcutaneous transplants, and multiple intrapulmonary tumour nodes formed after its intravenous inoculation (the first transplant generations had no such capacity); the morphological anaplasia of the tumour increased. These changes were not directly dependent on the changes in its immunogenicity.

Adenocarcinoma↗