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Biomedical subjects

G A Edwards

Publications and source records attributed to G A Edwards.

At least 55 records · Page 3Linked to original sources
PubMed1982

Causation of insanity in nineteenth century Australia.

In this article an endeavour has been made to explore the writings of Frederick Norton Manning as they pertain to understanding nineteenth century medical viewpoints in Australia as to the causation of mental disease. Of particular note are the concept of hereditary weakness and issues related to the harsh Australian environment and the developing colonial society. These writings reveal, in large part, the use of a scientific approach and some concepts of causality which, for the times, were highly sophisticated. Nevertheless, some highly speculative theorizing does occur.

Australia↗
PubMed1981

Focal glomerulosclerosis. Extent of involvement related to steroid resistance.

Biopsies were done for 27 nephrotic children whose presentations were compatible with minimal lesion nephrotic syndrome. Percentages of glomeruli involved by focal glomerular sclerosis and its subtypes were calculated. The presence or absence of interstitial disease was noted. These histologic findings were correlated with steroid responsiveness. All patients who had greater than 5% of glomeruli involved by focal glomerular sclerosis resistant to steroids. Interstitial disease was present in ten of the 27 patients studied; eight of the ten were resistant to steroids. Steroid resistance was found to be associated not with the mere presence of focal glomerular sclerosis but rather with its extent and the presence of interstitial disease.

Adolescent↗
PubMed1980

The case of William Chidley: a study in psychiatry, morality and lunacy law.

William Chidley was a unique Australian. He lectured frequently on his beliefs that the answer to society's problems was a three-fold program of correct dress, proper diet and a new method of sexual intercourse. His compulsory admissions to psychiatric hospitals were on the grounds that he was insane and a danger to public morals. The case raised basic questions in psychiatry, morality and lunacy law. These questions, which are discussed, are still of contemporary significance.

Australia↗
PubMed1979

The mental illness of Captain Hyndman.

The mental illness of Captain Charles Robertson Hyndman resulted in his compulsory hospitalization in Tarban Creek Asylum in 1843 and 1864-1866. His illness, and the question of mental health law which was subsequently raised, were of great significance for the colony of New South Wales in that it led to the first specific lunacy legislation in the state. The issues raised are still the fundamental questions with which contemporary mental health law is concerned.

Adult↗
PubMed1977

High-altitude pulmonary edema in children.

A 15-year-old boy with recurrent high-altitude pulmonary edema had previously been mistakenly treated for asthma and pneumonia. Clinical manifestations of this disorder, its etiology, treatment, and prevention are discussed.

Acclimatization↗
PubMed1977

Effectiveness of low-dose continuous intravenous insulin infusion in diabetic ketoacidosis. A prospective comparative study.

Twenty pediatric patients with diabetic ketoacidosis were randomly assigned in equal numbers to receive insulin either as a low-dose continuous intravenous infusion or as high-dose intermittent subcutaneous injections. Blood was obtained hourly for determinations of total CO2, plasma glucose, and osmolality, and, in previously untreated patients, plasma insulin. Serum values of beta hydroxybutyrate, electrolytes, and acetone were monitored every two hours. Plasma insulin levels were in the therapeutically effective range with each method of administration. There were no statistically significant differences in rate of correction of ketoacidosis, rate of reduction of plasma glucose, or decline in plasma osmolality. The incidence and the severity of hypokalemia were increased in the patients receiving subcutaneous insulin. There was less variation in the rate of reduction of plasma glucose in the infusion group. Low-dose continuous intravenous infusion of insulin is at least as effective in treating diabetic ketoacidosis as the traditional high-dose intermittent subcutaneous injection of insulin and offers some definite advantages.

Adolescent↗
PubMed1977

Formation of methionine from alpha-amino-n-butyric acid and 5'-methylthioadenosine in the rat.

Adult rats may utilize two metabolites of methionine for the biosynthesis of this essential amino acid. In separate experiments methionine, labeled with 14C or with 35S was observed in plasma and urine following the administration of [2-14C]-alpha-amino-n-butyric acid or [35S]-5'-methylthioadenosine by stomach tube. Although alpha-amino-n-butyric acid (ABA) or homoserine, alone or with dietary sodium sulfate, choline, and/or S-methylcysteine, was not utilized for growth, weight loss in weanling rats was decreased by dietary cysteine when fed as an additive to a basal methionine-free, cysteine-free, labile methyl-free, sulfur-free diet. Following the addition of 10 mg ABA and 28 mg 5'-methylthioadenosine/day to the basal diet, growth response was equivalent to that occurring in rats receiving 27 mg of methionine/day with the basal diet. The implications of these findings for adaptation to protein restriction and a discussion of equilibrium and steady state conditions related to the increase in methionine content in the blood are presented.

Adenosine↗
PubMed1975

Cataracts in bleomycin-treated rats.

Bleomycin was administered to 126 normal or human-tumor-bearing baby rats we observed for the development of cataracts. Eighty-four percent of the rats receiving this drug before the age of 10 days developed lens opacities. Bleomycin given to 10-day-old rats or older did not induce cataract formation. The cataracts initially occurred in the nuclear area and later involved most of the lens whether or not bleomycin was later discontinued. The presence of the tunica vasculosa lentis in rats younger than 10 days old may explain why cataracts developed only in these young animals.

Age Factors↗