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Biomedical subjects

G A Buckley

Publications and source records attributed to G A Buckley.

36 records · Page 2Linked to original sources
PubMed1970

Temperature modulation of alpha- and beta-adrenoceptors in the isolated frog heart.

1. The effects of adrenaline on the isolated frog's heart at 27 degrees C are not antagonized by phentolamine (1.5 x 10(-6)M) but are abolished at 7 degrees C.2. At 27 degrees C isoprenaline was more potent than noradrenaline, but at 7 degrees C noradrenaline was more potent than isoprenaline.3. Phenoxybenzamine (1.5 x 10(-5)M) or dibenamine (1.5 x 10(-5)M) at 7 degrees C abolished the work output induced by adrenaline. When the temperature was raised to 24 degrees C, adrenaline caused an increase in work output.4. It is concluded that in the isolated frog heart there are at least two pools of adrenoceptors, the availability of which can be governed by temperature.

Animals↗
PubMed1968

A quantitative study of cholinesterase in myoneural junctions from rat and guinea-pig extraocular muscles.

1. Cholinesterase staining of rat and guinea-pig extraocular muscle shows focally and multiply innervated fibres.2. The distribution of cholinesterase activities in the populations of focal endings (from singly innervated fibres) and fine motor endings (from multiply innervated fibres) was determined by a sensitive radiochemical method.3. Focal endings had a greater cholinesterase activity than fine motor endings.4. It is suggested that this difference in enzyme activities is related to the functional difference between twitch and slow fibres in extraocular muscle.

Animals↗