Biomedical subjects

Fridolin Okkels

Publications and source records attributed to Fridolin Okkels.

3 recordsLinked to original sources

PubMed2006

Universality in edge-source diffusion dynamics.

We show that in edge-source diffusion dynamics the integrated concentration N(t) has a universal dependence with a characteristic time scale tau=(A/P)2pi/(4D), where D is the diffusion constant while A and P are the cross-sectional area and perimeter of the domain, respectively. For the short-time dynamics we find a universal square-root asymptotic dependence N(t)=N0(sqrt)t/tau while in the long-time dynamics N(t) saturates exponentially at N0. The exponential saturation is a general feature while the associated coefficients are weakly geometry dependent.

Journal Article↗

PubMed2005

Reexamination of Hagen-Poiseuille flow: shape dependence of the hydraulic resistance in microchannels.

We consider pressure-driven, steady-state Poiseuille flow in straight channels with various cross-sectional shapes: elliptic, rectangular, triangular, and harmonic-perturbed circles. A given shape is characterized by its perimeter P and area A which are combined into the dimensionless compactness number C= P2/A, while the hydraulic resistance is characterized by the well-known dimensionless geometrical correction factor alpha. We find that alpha depends linearly on C, which points out C as a single dimensionless measure characterizing flow properties as well as the strength and effectiveness of surface-related phenomena central to lab-on-a-chip applications. This measure also provides a simple way to evaluate the hydraulic resistance for the various shapes.

Journal Article↗

PubMed2003

Reaction-diffusion dynamics: confrontation between theory and experiment in a microfluidic reactor.

We confront, quantitatively, the theoretical description of the reaction-diffusion process of a second-order reaction to experiment. The reaction at work is Ca(2+)/CaGreen, a fluorescent tracer for calcium. The reactor is a T-shaped microchannel, 10 microm deep, 200 microm wide, and 2 cm long. The experimental measurements are compared with the two-dimensional numerical simulation of the reaction-diffusion equations. We find good agreement between theory and experiment. From this study, one may propose a method of measurement of various quantities, such as the kinetic rate of the reaction, in conditions yet inaccessible to conventional methods.

Biophysics↗