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Biomedical subjects

F de Waard

Publications and source records attributed to F de Waard.

At least 73 records · Page 4Linked to original sources
PubMed1981

Unexpected trends in the analysis of a questionnaire and interview procedure to detect transient cerebral ischemic attack in a female population.

By means of a case-control study, social and biomedical factors were considered in relation to transient cerebral ischemic attack occurrence as determined by questionnaire and interview among a population of females ( greater than 50 years of age) residing in the city of utrecht and surroundings. Contrary to earlier expectations, a greater TIA risk was found associated with: lower systolic and diastolic blood pressure, a low-salt diet for high blood pressure, lower body weight, smaller body surface, and use of medicines for cardiac insufficiency/arrhythmias and chronic anxiety. The importance of hemodynamic processes (i.e. hypotensive episodes of cerebral circulation) for TIA within the general population is emphasized.

Aged↗
PubMed1981

Plasma oestrone, oestradiol and androstenedione levels in post-menopausal women: relation to body weight and height.

To study the relation between body weight and height and the plasma sex-hormone levels wer measured the plasma levels of oestrone (E1), oestradiol (E2) and androstenedione (A) in a group of healthy post-menopausal women with a wide range of body weight. The sex hormones were measured by radioimmunoassay with highly specific antisera after purification of the plasma extract by column chromatography. Our findings show that there is significant positive correlation between the E1 level and body weight as well as A level and, to a lesser extent, between the E1 level and Quetelet index. For E2 there is no correlation with these parameters. There is also a very slight correlation between A level, body weight and Quetelet index. Calculation of the partial correlation coefficient shows that E1 correlates to the same degree with body weight and A level, whereas the A level does not correlate with body weight at a fixed value for the E1 level. We conclude that variation in the E1 level depends to the same degree on the variation in body weight as well as the variation in A level.

Androstenedione↗
PubMed1981

Relationship of weight to the promotion of breast cancer after menopause.

Epidemiologic and experimental evidence for a relation between high body weight and breast cancer is reviewed. A prospective study in the framework of a population-based breast cancer screening project for women over age 50 with determination of estrogen-receptor-status of cancers has provided evidence that promotion of ER-positive cases is favored by obesity and relatively inhibited by leanness. In lean postmenopausal women, clonal selection is thought to lead to a preponderance of ER-negative cells in the cancers. Initiation of breast cancer is probably unrelated to obesity. Induction of breast cancer may be rare after menopause, but existing tumors grow if they receive stimuli to which they are sensitive. A lead to further research is presented.

Aged↗
PubMed1980

Plasma prolactin levels in women at postmenopausal age with a family history of breast cancer or a prescription for antihypertensive Rauwolfia treatment.

An investigation was made of daytime plasma prolactin levels in three groups of women aged 50 to 64 years: (1) 139 women with a family history of breast cancer; (2) 50 women on Rauwolfia treatment for hypertension, and (3) 90 women of a control group. A significant difference in prolactin levels was found between groups 2 and 3 but not between 1 and 3. These findings are considered in relation to the results of a breast cancer screening programme in which the women took part. Here, it was the women with a family history of breast cancer who showed an increased breast cancer risk, whereas the risk in women on Rauwolfia was not significantly higher than expected on the basis of the experience among controls. It is concluded that the role of prolactin in the etiology of breast cancer is still not clear.

Breast Neoplasms↗
PubMed1979

Ratio of 11-desoxy 17-oxosteroids to creatinine in a population screened for breast cancer.

During a population-based screening project for breast cancer, almost 15,000 women aged 50 years and over have provided a 12 h (overnight) sample of urine for research purposes. In 3,789 women the excretion of 11-desoxy-17-oxosteroids (DOOS) and creatinine was measured. Results were analysed in terms of urinary concentrations and of a ratio between DOOS and creatinine. Age had an effect on DOOS, creatinine and their ratio. Body weight and body surface area had an effect on creatinine excretion and therefore on the ratio. The following variables did not have an appreciable effect on the above-mentioned ratio: a family history of breast cancer, parity and age at first pregnancy, menopause and oestrogenic drugs, and parenchymal pattern of the breast as observed on the xeromammogram. Breast cancer was found at first screening in 106 out of 14,697 women. In 100 of these cases DOOS and creatinine were measured. Excretion values expressed as the ratio between the two, allowing for body surface area, did not differ materially from those of 100 age-matched controls. These results lead the authors to the conclusion that the determination of androgen metabolite excretion in women over 50 years of age is of no help in selecting a group at high risk of breast cancer.

17-Ketosteroids↗
PubMed1978

Body Mass Index.

Explore the source record for details and available documents.

Body Height↗
PubMed1977

Relationship between steroid excretion patterns and breast cancer incidence in Israeli women of various origins.

A nationwide study of the steroid excretion patterns in postmenopausal Israeli migrant women demonstrated differences between high- and low-risk groups for breast cancer in the following variables: age at first parturition, number of pregnancies, number of live births, height, and weight. The direction of the differnces was in line with those observed for breast cancer patients. The groups also differed in the exretion of estriol, 17-ketosteroids, and allotetrahydrocortisol. Multiple regression analysis revealed that the exretion of estriol was significantly lower in population groups in whom breast cancer incidence was high. Possibly this trend--which has also been observed in adolescent and premenopausal women--reflected environmental influences on peripheral estrogen metabolism.

17-Ketosteroids↗
PubMed1975

Breast cancer incidence and nutritional status with particular reference to body weight and height.

The epidemiological literature on breast cancer is reviewed with particular emphasis on the possible etiological role of nutritional status as reflected by weight and height. The results of a prospective study and preliminary results of a population-based case-control study seem to indicate that body size or body mass rather than overweight (obesity) is a risk factor. A considerable proportion of the differences in incidence between the Netherlands and Japan can be explained by differences in body mass. The biological mechanisms mediating nutritional status and breast cancer are believed to be of an endocrinological-metabolic nature.

Body Height↗