Biomedical subjects
Publications and source records attributed to F Ziade.
We described in this report a case of post-herpetic neuralgia refractory to medical therapy that was successfully treated with repetitive injections of local aesthetic mixture (bupivacaine 0.5% 19 ml and clonidine 150 microg ml(-1) 1 ml) every 48 h for 3 weeks using a paravertebral catheter inserted at T2-T3 level.
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An algorithm (Stoke index) has been designed to give a global measure of disease activity in rheumatoid arthritis. This algorithm has been created as an easy to use flow diagram based on two objective laboratory measures (C-reactive protein and erythrocyte sedimentation rate), one subjective and two semi-objective clinical measures (morning stiffness, synovitis score and Ritchie articular index). Results of six clinical markers and seven laboratory markers of disease activity on a cohort of 371 rheumatoid patients have been used to evaluate the algorithm and compare it with a previously described index of disease activity (Mallya-Mace index). Principal component analysis validates its ability to measure disease activity. Sensitivity is described by the distribution of patients between the two index scores. Change in index score by patients over a 6-month period indicates reversibility. The Stoke index demonstrates greater sensitivity and reversibility than the Mallya-Mace index. These findings indicate that the algorithm described provides a useful index of global disease activity for use in the assessment of rheumatoid arthritis.
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Pharmacological exploration of the central nervous system carried out by means of a series of tests confirms the affinity of 3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid alpha-cyano-3-phenoxybenzyl ester (delta-methrin) for the nervous system and reveals the following activities of deltamethrin: Deltamethrin has no neuroleptic or sedative action. It inhibits motility, sense of balance and inquisitiveness of treated animals. It potentiates chloral-induced hypnotic action but not that of pentobarbital. Not only does it have no antagonistic action on convulsivant agents: electric shock, pentetrazol, strychnine, but it stimulates their toxicity and prolongs the convulsive seizures. The fact that deltamethrin acts on different convulsivant agents (i.e. pentetrazol and strychnine) with various sites of action suggests that its activity is located in both the cortical and the medullary centres. Deltamethrin reveals the latent toxicity of tryptamine used in the non-toxic dose range; this predicts that deltamethrin might have an IMAO (inhibitor of monoamine oxidase) activity. Experiments carried out under the conditions adopted showed that deltamethrin acts on various sites.