Artificial reticuloendothelial system, which was made on an immobilized phenylalanine column, has been developed to remove denatured protein from serum. This system was used to treat systemic lupus erythematosus effectively. Lupus angiitis has been markedly improved with 12 treatments.

Adult↗

PubMed1984

Autoregulation of cerebral blood flow in young and aged spontaneously hypertensive rats (SHR).

Autoregulation of cerebral blood flow (CBF) to the controlled hemorrhagic hypotension was studied in young adult spontaneously hypertensive rats (SHR, 3.4 months of age) and aged SHR (20.3 months). There were no differences in average values for mean arterial pressure and baseline CBF between two groups of rats. During hypotension, however, CBF was more reduced in aged SHR than in young SHR, indicating that the lower limit of cerebral autoregulation is shifted to a higher level in aged SHR. Such upward shift of the autoregulation is likely due to a long-lasting hypertension which may lead to the diminished vasodilatory response of the brain to hypotension.

Aging↗

PubMed1983

Mass transfer rates in hemodialyzers--an empirical correlation.

From the experimental data on the rates of urea transfer from blood to dialysate in a test hemodialyzer, a practical equation for the effect of the hematocrit on the blood-phase urea transfer coefficient is proposed. With this equation, the overall mass transfer coefficient that takes into account the properties of the blood can be estimated for the commercially available disposable flat membrane-type and hollow fiber-type hemodialyzers from the data for a relatively simple dialysate--dialysate system.

Animals↗

PubMed1983

[Principles of mass transfer].

Explore the source record for details and available documents.

Biological Transport↗

PubMed1983

[Effects of hypo- or hyperglycemia on brain metabolism in experimental cerebral ischemia].

Glucose, lactate, pyruvate and adenosine triphosphate (ATP) concentrations in the supratentorial brain tissue frozen in situ were measured one hour after bilateral carotid occlusion in spontaneously hypertensive rats, of which blood glucose levels were varied by intraperitoneally injected insulin (hypoglycemia), saline (normoglycemia) and 50% glucose (hyperglycemia). Cerebral glucose concentrations as well as blood glucose levels were significantly increased in hyperglycemic animals, and decreased in hypoglycemic ones. Cerebral lactate, and lactate/pyruvate ratio at one-hour ischemia tended to increase in hyperglycemic animals comparing with those in normoglycemic ones, although cerebral ATP levels were slightly higher in the former. In hypoglycemic animals with one-hour ischemia, cerebral lactate was less increased but ATP was significantly reduced. It has been reported that hyperglycemia has vulnerable effects on brain metabolism of complete cerebral ischemia, presumably due to hyperglycemia-induced lactic acidosis of the brain. In incomplete cerebral ischemia as demonstrated in the present study, however, ATP concentrations remained at slightly higher level, despite tendency to more increase in lactate in hyperglycemic animals, indicating that high blood glucose level might be beneficial, rather than vulnerable, to incomplete cerebral ischemia. On the other hand, hypoglycemia causes more severe impairment of the brain energy metabolism because of an insufficient supply of substrates to the brain.

Adenosine Triphosphate↗

PubMed1982

Preparation of specific antiserum to estradiol 3-glucuronide.

The preparation and antigenic properties of estradiol 3-glucuronide-bovine serum albumin (BSA) conjugate in which the hapten is coupled to the carrier protein through the aminomethyl group at C-6 by glutaraldehyde, have been described. Antibody raised against the immunogen in the rabbit possessed high affinity (Ka = 3.7 x 10(9) M-1) and excellent specificity to estradiol 3-glucuronide, exhibiting no significant cross-reactivities with estrogen glucuronides except for estriol 3-glucuronide (3.64%) and no cross-reactions with free estrogens, their sulfates and other steroids.

Animals↗

PubMed1981

[The changes of physiological and cognitive responses caused by approaching of other person (author's transl)].

The changes of physiological responses (heart rate, eye blink) and subjective feelings (anxiety, tension, apparent size of the model) caused by approaching of other person (a model) were examined using two groups of subjects (eye-contact group and non eye-contact one). The results were as follows. (a) Eye-contact subjects tended to keep longer personal distances than non eye-contact ones. (b) Anxiety, tension, and apparent size of the model increased gradually as the model approached. In contrast the physiological responses increased abruptly at Distance 5, while decreasing slightly from Distance 1 to 4. (c) INDSCAL analysis revealed that the subjective indices formed one cluster but the heart rate and eye blink were situated differently. (d) Those who obtained high neurotic scores attributed exaggerated anxiety or tension to the situation. (e) The relation between eye blinks and tension reduction was discussed.

Adolescent↗

PubMed1980