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Biomedical subjects

F Y Zhao

Publications and source records attributed to F Y Zhao.

36 records · Page 2Linked to original sources
PubMed1990

[The results of treatment in 570 cases of oral cancer].

This paper presents results of treatment in 570 cases with oral cancers. The overall 5-year survival rate was 64.5%; and 92.8%, 84.9%, 50.2% and 16.4% respectively in Stage I, II, III and IV. Five kinds of therapy have been used and discussed. The mortality rate of operation was 0.35%. The 5-year survival rates of 127 and 443 cases with and without cervical node metastases were 28.3% and 74.7% respectively. The 5-year survival rates of 81.30 and 16 cases with involvement of 1.2 and more than 3 nodes were 33.6%, 27.9% and 6.3% respectively. 46 cases recurred and operated again, their 5-year survival rate was 23%.

Adult↗
PubMed1989

Treatment of 570 cases of oral squamous cell carcinoma.

This paper presents results of treatment in 570 cases with oral cancers. The overall 5-year survival rate was 64.5% and 92.8%, 84.9%, 50.2% and 16.4%, respectively for Stages I, II, III and IV. Five kinds of therapy have been used and discussed. The mortality rate of operation was 0.35%. The 5-year survival rate of 127 and 443 cases with and without cervical node metastases was 28.3% and 74.7% respectively. The 5-year survival rates of 81, 30 and 16 cases with involvement of 1, 2 and more than 3 nodes were 33.6%, 27.9% and 6.3% respectively. The 5-year survival rates were 35.5%, 14.4% and 0% when upper, middle and lower cervical nodes were respectively involved. Forty-six cases recurred and were operated on again, their 5-year survival rate was 23%.

Adult↗
PubMed1989

[Studies on anordrin injection for termination of early pregnancy in mice].

In order to increase the effectiveness on the termination of early pregnancy, anordrin injection was prepared. A nonaqueous solvent was selected as the parenteral solvent which was not irritating and toxic. The security test showed the injection was also not irritating and toxic. After the injection was heated for 76 h in 95 +/- 2 degrees C water or stored for 3 mon at 37 degrees C, the content of anordrin showed no change. The activation energy of the injection was 68.1 kJ/mol determined by thermogravimeter analysis. This also showed that the injection was steady. Results of termination of early pregnancy in mice showed that a single dose of anordrin injection (3 mg/kg) intraperitoneally was more effective than a single dose of anordrin tablet (3 mg/kg) orally (P less than 0.01). Histological studies showed that embryo, decidual cells and nutrient cells were markedly degenerated or dead when treated with the injection (3 mg/kg) intraperitoneally.

Abortifacient Agents↗
PubMed1989

[Morphological observation of termination of early pregnancy with anordrin in mice].

Twenty four mice were divided randomly into experimental and control groups. There were 10 animals in the control group. In experimental group, anordrin (3 mg/kg) was injected into the peritoneal cavity to terminate early pregnancy. The control group was treated with normal saline. Pathological changes in the decidual cells, blastocysts (including giant cells), corpora lutea and embryo were observed. It was found that the animals in the control group were developing normally. In all the experimental groups decidual cells and blastocysts showed degeneration and necrosis. The granulosa lutein cells also showed degeneration. The dead embryo was embedded in the necrotic decidual cells and blastocysts. The mechanism concerned may involve a combination of various factors. The degeneration of granulosa lutein cells may be the most important of the factors.

Animals↗
PubMed1989

[Studies on coprecipitate of anordrin-PVP].

The coprecipitate of anordrin (AD)-PVP was prepared by solvent method. The DSC (differential scanning calorimetry) revealed that AD did not have crystalline structure in coprecipitates of 1:7-1:9. X-ray diffraction spectrum of 1:8 coprecipitate (COPPT) showed no crystalline structure of AD. The dissolution rate of AD was about 38 times higher for 1:8 COPPT than pure AD. Activation energies determined by DTG (derivative thermogravimetry) were 182.8 and 133.4 kJ/mol, respectively, showing that the 1:8 COPPT is much more stable than pure AD in thermal degradation. The experimental results showed that anti-implantation effect of the 1:8 COPPT was much better than that of AD tablets: the number of implantation sites of mice administrated 1:8 COPPT (5 mg/kg) was 0.2 (P less than 0.01) and that of mice administrated AD tablets (10.6 mg/kg) was 0.9 (P less than 0.05); effective dose of 1:8 COPPT was less than half of that of AD tablets.

Animals↗
PubMed1985

Hematoporphyrin derivative and laser photodynamical reaction in the diagnosis and treatment of malignant tumors.

This paper reports the use of hematoporphyrin derivative (HpD) with laser activation in China for the diagnosis and treatment of various kinds of malignant neoplasms. Fluorescence observation for diagnosis was performed for 170 tumors. One hundred and fifty-one (88.8%) fluoresced visably upon excitation with either argon or He-Cd laser light. One hundred and thirty-nine malignant tumors in 136 patients were treated by this method. The percentage of all tumors responding to treatment was 80.6%. Partial to complete response were obtained in 51.1% of the tumors treated. The advantages and disadvantages of this method are discussed. It was found effective in treating various kinds of neoplasms located at different anatomical sites. The penetrating depth of the laser is shallow. This limits its effect and application. A search for new photosensitizing drugs and an increase in the penetrating depth of laser irradiation are urgent goals for further development of this technique.

Antineoplastic Agents↗