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Biomedical subjects

F Y Chang

Publications and source records attributed to F Y Chang.

At least 271 records · Page 15Linked to original sources
PubMed1989

[Diabetic ketoacidosis and hyperglycemic hyperosmolar nonketotic coma--a reappraisal after seven years].

In treating DKA and HHNK, low dose insulin therapy has been confirmed to be efficient and with less complications than traditional high dose insulin therapy. In 1981, we have reported 157 cases of DKA and HHNK at VGH. Between January 1986 and December 1987, 98 cases of DKA and HHNK were encountered at VGH. 40 patients had 48 episodes of DKA their mean age were 56 years. Comparing with the previous report, we found that the main precipitating factors were infection (41.6% vs 38.8%), omission of insulin (27.1% vs 34.7%) and there were cases without any precipitating factors (18.7% vs 24.8%). 3 cases died (6.2% vs 7.3%) in three days. During treatment, hypoglycemia were found in 4 cases (8.3% vs 5.2%) and hypokalemia were noted in 30 cases (62.5% vs 42.3%). 47 patients had 50 episodes of HHNK, their mean age were 68.7 years. Comparing with the previous experience, the main precipitating factors were infection (44% vs 45.7%), omission of insulin (16% vs 20%) and cardiovascular disorder (12% vs 31.4%), there were some episodes without any precipitating factors (20% vs 8.6%). 10 cases died (20% vs 20%) in three days, hypoglycemia were noted in 2 cases (4% vs 3%) and hypokalemia in 20 cases (42% vs 27.3%). It seems, even with better knowledge, facilities and increased experience in the management of diabetic emergencies, no dramatic change in morbidity and mortality was noted over the past 7 years.

Aged↗
PubMed1989

The relation between Campylobacter pylori and inflammatory cell infiltration of antral mucosa in patients with dyspepsia.

In order to understand the relation between the prevalence of Campylobacter pylori and the severity of gastritis, we conducted a survey of 166 randomly selected dyspeptic patients. The presence of C. pylori on the antral mucosa was aseptically determined by both urease and bacterial culture tests. Specimens of antral mucosa were obtained for pathologic gradings of inflammation: active gastritis, mononuclear cell infiltration C0 (nil) to C3 (lymphoid follicle); presence or absence of intestinal metaplasia. Pathologically, chronic gastritis was invariably present in almost all patients with dyspepsia: three-fourths of them showed evidence of active gastritis, one-third showed intestinal metaplasia. Half of the dyspeptic individuals had C. pylori colonization. The results suggest that the prevalence of C. pylori was closely related to the different grades of active gastritis; neither the different grades of chronic gastritis nor intestinal metaplasia affected the prevalence of C. pylori on gastric mucosa. We conclude from this study that C. pylori is closely related to active chronic gastritis because of the common presence of chronic gastritis in patients with dyspepsia.

Adult↗
PubMed1989

Opsonophagocytosis of Staphylococcus aureus by diabetics' sera and monocytes.

The ingestion and the intracellular killing of Staphylococcus aureus by monocytes from patients with noninsulin-dependent diabetes mellitus (NIDDM) under good control (mean 2-h postprandial blood glucose less than 150 mg/dl in the past 6 months) or under poor control (mean 2-h postprandial blood glucose greater than 200 mg/dl in the past 6 months) were investigated. The ingestion was expressed as a phagocytic index which was a percentage of the total bacteria added in the reaction mixtures, while the intracellular killing was expressed as the percentage of ingested bacteria which were destroyed. The phagocytic index (mean +/- S.E.) of healthy subjects (HS), diabetics under good control (DGC) and diabetics under poor control (DPC) were 45.1 +/- 3.5, 38.2 +/- 2.2, and 32.1 +/- 3.4%, respectively. This showed that monocytes from diabetics ingested S. aureus more poorly than did those from HS (p less than 0.001) and monocytes from DPC ingested more poorly than did those from DGC (p less than 0.001). There was no difference in intracellular killing between HS and DGC, but a marked difference was noted between DGC and DPC. Specific antibodies (IgG) as demonstrated by indirect immunofluorescence assay had little effect on ingestion but could enhance complement activation and then increase ingestion whether the serum was from HS, DGC, or DPC. On the other hand, the significant effect of complement activity in the presence of specific antibodies on intracellular killing was only observed on HS and DGC, suggesting that antibody-dependent complement activation could be a crucial mechanism for efficient intracellular killing.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

A comparison of various methods for the determination of viability of parasitic flagellates.

To find out a simple, rapid, accurate, and reliable viability assay for in vitro anti-protozoa drug testing, a comparison among the various methods for the determination of flagellate viability was made. Micro-colony forming efficiency up to 90% for three different flagellates was obtained by the agar plate method. Macro-colony forming efficiency obtained by the culture tube method was generally lower (20-45%). Viability determined by trypan blue exclusion correlated closely with viability determined by micro-colony count (r = 0.94). The growth of the remaining parasites survived from serum treatment was not inhibited while that from metronidazole pretreatment was inhibited. The standard regrowth assay based on the 48-hr cultivation could be applied only for those survival not inhibited. The inhibitory effect of metronidazole on parasites was further testified by the longer generation time for metronidazole-pretreated flagellates in comparison with that for control (p less than 0.001). If the inhibitory effect of a drug is involved in the mechanisms against parasites, only the trypan blue exclusion and the micro-colony count can give an accurate and reliable viability determination. Moreover, the simple and rapid diagnosis provided by trypan blue exclusion is especially useful for the in vitro anti-protozoa drug susceptibility test.

Animals↗