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Biomedical subjects

F Woimant

Publications and source records attributed to F Woimant.

80 records · Page 5Linked to original sources
PubMed1980

HLA-A and B typing in the Sarakole population of West Africa.

The distribution of HLA genes and haplotype frequencies was studied in a population of 119 Sarakole West Africans. The absence of HLA-B15, the rarity of HLA-A10, B12 and B17 and the relatively high frequency of HLA-A2 and B5 were noted. The presence of a Da 6 gene in the African populations is confirmed. The main gametic associations were Aw19-Bw35 and Aw23-B5.

Africa, Western↗
PubMed1979

[Cerebral manifestations of sarcoidosis (author's transl)].

Sarcoidosis lesions in the brain are relatively rare and can remain latent, or become evident in various forms: meningitic, encephalitic, neuro-endocrinian, vascular, or tumoral. A case is reported of an Antilles patient aged 35 years, in whom the diagnosis was made by examination of an operation specimen, following the discovery of an apparently isolated intracranial hypertension.

Adult↗
PubMedDate not supplied

Cardiac papillary fibroelastoma: aA rare cause of ischemic stroke in the young.

Among etiologies of stroke in young adults, primary cardiac tumors are very rare. We report the case of a 37-year-old woman who was admitted for an ischemic stroke in the right middle cerebral artery region. Etiologic investigations revealed, after transthoracic and transesophageal echocardiography, an aortic valve tumor. Treatment was first medical with anticoagulation, then surgical. Histological examination showed a papillary fibroelastoma. After a review of the literature, the possible mechanisms of the ischemic event are discussed and lead to the conclusion that this tumor must be surgically excised, even if asymptomatic, because of recurrent ischemic complications responsible for myocardial infarction, stroke and sudden death.

Adult↗
PubMedDate not supplied

[Wilson disease: clinical and biological aspects].

Wilson disease is an autosomal recessive disorder of copper excess. This illness results from mutations of the ATP7B gene (chromosome 13, MIM# 277900). The discovery of the gene allowed a better understanding of cytosolic copper trafficking and its relationship with ceruloplasmin synthesis. Symptomatic patients may present with hepatic, neurologic or psychiatric forms. Clinical and phenotypic evidences provide only presumptive arguments for this disease which can be routinely assessed by molecular analysis. This genetic disease which can be efficiently treated was formerly biologically suspected after a careful but sometimes invasive study of copper metabolism. Genetic advances can now give a definite answer using linkage analysis and research for disease-causing mutations. However, this diagnosis strategy is limited since currently over 320 mutations and 80 polymorphisms have been currently identified.

Adenosine Triphosphatases↗
PubMedDate not supplied

Spontaneous dissection of the internal carotid artery in 68 patients.

OBJECTIVES: Our purpose was to know more about the symptoms and clinical and radiological outcome of spontaneous dissections of the internal carotid artery in a retrospective study of 68 patients aged 20 to 71 (mean 46). METHODS: The diagnosis of dissection was based on angiographic findings. Nine percent of patients had minor symptoms such as a subjective bruit or painful Horner's syndrome, without an ischaemic event. Cerebral ischaemia was present in 90% of cases and occurred within a month of the initial event in all cases but one and was the first symptom in 53% of cases. RESULTS: Magnetic resonance imaging performed in 21 cases showed haemorrhage in the vessel wall. Resolution of the angiographic appearances occurred in 65% of cases after 3 months. In cases of stroke, more than half of the patients had poor functional outcome, factors conveying poor prognosis were massive stroke, embolic mechanism and lack of local recanalization. CONCLUSION: Spontaneous dissection of the internal carotid artery is not a rare cause of cerebral ischaemia and can present with minor symptoms without an ischaemic event. Doppler ultrasonography and magnetic resonance imagery are helpful in diagnosis and follow-up.

Adult↗