Biomedical subjects

F Wierrani

Publications and source records attributed to F Wierrani.

40 records · Page 3Linked to original sources

PubMed1990

[Is consecutive curettage of the corpus uteri indicated in every conization case?].

Endometrial curettage at the time of conisation is often performed as a routine procedure, even when indication for this treatment is rather unclear. 593 conisations including curettages were performed at the I. Department of Obstetrics and Gynaecology, of the University of Vienna and were evaluated retrospectively. Only 3 patients with a mild endometrial hyperplasia were found. Therefore, in our opinion, there is no indication for a curettage at the time of conisation, if a woman is under the age of 35 years and if there is no other specific indication for sampling the endometrium, based on high risk factors, physical examination, history or abnormal glandular cells found on cervical cytology. Such management would result in reducing the costs and the risk of infection in intrauterine operations.

Adult↗

PubMed1990

[Documentation of the surgical report with graphic statistical data analysis--a simplification of daily routine work].

A data collection system on microcomputer connected with an automatic medical report system for operations, was developed to facilitate both medical report as well as documentation. Linking different commercial software products by use of a Pascal programme, we were able to speed up daily routine work as well as establish efficient graphical statistics of patient data.

Cesarean Section↗

PubMed1988

[Metastatic spread of extramammary malignant melanomas to the female breast and the clinical consequences].

Two cases of melanomas with the one site of localisation of metastases in the breast are presented. The conclusion is to perform a two step operative therapy of breast tumor for patients with a history of melanoma to avoid unnecessary mutilating operations.

Aged↗

PubMedDate not supplied

Photodynamic action of meta-tetrahydroxyphenylchlorin (mTHPC) on an ovarian cancer cell line.

Meta-tetrahydroxyphenylchlorin (mTHPC) exhibits significant cytotoxicity against a variety of human cells in culture in combination with light, but also in dark reaction. The ovarian cancer cell line SK-OV3 was incubated with various concentrations of mTHPC and in comparison with Taxol and Cisplatin: then the effect on cell growth was determined. mTHPC exhibited an IC50 of 0.9 muM after 24 hours incubation (IC50 of 1.25 after 2 hours), whereas Cisplatin and Taxol, which, have been used as first line agents for the treatment of ovarian carcinomas, inhibited cell proliferation with an IC50 concentration of 4.6 muM and 78 nM after 24 hours incubation, respectively. Incubation of SK-OV3 cells with mTHPC for 5 days resulted in cytostatic cytotoxicity at a concentration of 0.5 muM. The photodynamic effect of mTHPC depends/among other parameters/on the concentration of the dye present. In combination with light (approximately 15 J/cm2) a linear relationship between the dose of mTHPC and the amount of necrotic cells was observable. Higher concentrations of mTHPC caused necrosis of the ovarian tumor cells. The intracellular concentration of mTHPC showed a linear increase up to 28.6 nM (incubation concentration). In summary, these studies demonstrated that mTHPC exhibits potent antiproliferative activity by inducing necrosis after application of light. MTHPC might be a promising agent with cytostatic and photodynamic properties for the treatment of metastasing ovarian carcinomas. A sensitive PCR method was not able to show the induction of apoptosis in the SK-OV3 ovarian cell line. Using propidium staining, it could be proved that the cell death was caused by necrosis and not through apoptosis after irradiation with light.

Antineoplastic Agents↗