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Biomedical subjects

F W Schmidt

Publications and source records attributed to F W Schmidt.

At least 127 records · Page 7Linked to original sources
PubMed1978

[Reye's syndrome in adults (author's transl)].

The clinical picture of Reye's syndrome, characterized by an acute severe disease of brain and liver, initially has nonspecific generalized symptoms with cough, myalgia, and fever. The prognosis is poor. The disease starts with an infection, quickly followed by vomiting and loss of consciousness. In this phase the serum bilirubin is moderately raised, the transaminases markedly so. In addition to gastro-intestinal bleeding there may be hypoventilation, hypoglycaemia and seizures. Morbid anatomically there is a small-drop fatty infiltration of the liver and other organs with cerebral oedema. Aetiology and pathogenesis remain uncertain. Numerous therapeutic measures have been proposed.

Adult↗
PubMed1978

[Results of treating the acute stage of Crohn's disease by a dietary regimen (author's transl)].

23 consecutive patients (13 women, 10 men; mean age 31 years) with acute exacerbation of Crohn's disease were treated by a dietary regimen based on "resting" the bowel by parenteral nutrition or a balanced synthetic diet (Vivasorb), followed by stepwide introduction of a low-residue diet. Cardinal symptoms such as severe abdominal pain, diarrhoea, incomplete ileus or weight loss responded favourably to treatment in each case. Postoperative fistulae closed in two of three patients. Enterocutaneous fistulae, however, remained open in all five patients, although the volume of secretion decreased distinctly in four. During the follow-up period (averaging nine months after discharge from hospital) symptoms recurred in five patients, necessitating operative treatment in three.

Acute Disease↗
PubMed1978

[Hepatobiliary sequential-scintigraphy--progress in the evaluation of postcholecystectomy complains (author's transl)].

The hepatobiliary sequential-scintigraphy is a nuclear diagnostic procedure useful in assessing the function of liver and biliary system. 40 patients with and 20 patients without complains following cholecystectomy were examined. The value of this method in establishing biliary causes for such complains is demonstrated by typical cases. Simplicity and safety in application as well as diagnostic sensitivity should place the method in the first place evaluating postcholecystectomy complains. Succeeding indirect and direct radiologic techniques then may be used systematically with benefit for the patient and physician. Results indicate, that the procedure will be essential as well in evaluation as in analysis of nature and frequency of such complains by its superior presentation of intrahepatic bilestasis and functional mechanisms of the biliary system including the sphincter of Oddi.

Biliary Tract Diseases↗
PubMed1978

Sex differences of plasma cholinesterase in the rat.

Plasma cholinesterase activity of adult female HAN-Wistar rats was found to be 5.5-fold higher than that of adult male rats kept under constant specified pathogen-free (SPF) conditions up to their 870th day of life.

Age Factors↗
PubMed1978

Results of an epidemiological survey of enzootic bovine leukosis in the northern part of Lower Saxony and a preliminary communication of an examination into relationship between BLV-antibody development and calving.

The Agar-Gel-Immunodiffusion-Test as proposed by EEC has been carried out during the last 2 1/2 years within a defined test area of Lower Saxony. About 500 leukosis-infected herds with a total of about 20.000 head of cattle have been tested five times now within three to six months sequences. The AGIDT has proved to be an easy and very practical test for routine diagnosis in large scale surveys. Our results described again show the superiority of the glykoprotein-antigen over the ether-treated p24-antigen in the AGIDT. Slaughter of AGIDT-reactors within this population led to a fast decrease of leukosis-infection as detected by the test. Epidemiological herd-data show, that spreading of infection within a herd depends largely on direct contact between infected and noninfected animals. Moreover our data give rise to the suspicion that the manipulations during blood-sampling seem to be implicated in the spread of the disease within a herd. Possible reasons for inconsistencies of antibody-titer in infected animals are discussed.

Animals↗
PubMed1977

[The carrier potential of liposomes for methotrexate. Changing of the tissue levels of methotrexate in the organs of mice (author's transl)].

Drugs entrapped in liposomes (artificial lipid vesicles) exhibit different pharmacokinetics after intravenous application than drugs injected in a free form. The folidacidantagonist methotrexate can be entrapped in liposomes in a therapeutically useful concentration (0.5 mg MTX/ml) and can be stored with high stability of entrappment. After intravenous injection into the tail vein of mice liposomes entrapped methotrexate is found more enriched in cell systems with high rate of endocytosis and not eliminated by the kidneys within 3 h like free methotrexate. It can be shown, that for the organs liver, spleen, kidney, gut, lung, and blood over a 6 h period liposomes entrapped methotrexate is enriched in the tissues and that for example after 6 h the methotrexate level in the liver is 20 fold higher in comparison to free injected methotrexate.

Animals↗
PubMed1977

[Therapy of chronic hepatitis (author's transl)].

Therapy of chronic hepatitis as practized today is discussed, including general therapeutic procedures, the so-called "liver-protective substances", and drug therapy of chronic aggressive hepatitis and of liver cirrhosis. A causal treatment of chronic hepatitis is unknown; prognosis however can be improved by treatment with glucocorticoids as demonstrated by controlled clinical trials. A combination with azathioprin does have similarly good results with a decreased frequency of the unwanted side effects of the 2 drugs. The effects of other immunosuppressive drugs and of D-penicillamin cannot yet be evaluated sufficiently at present.

Anabolic Agents↗
PubMed1976

[Alterations of bile acid metabolism during treatment with chenodeoxycholic acid. Studies of the role of the appearance of ursodeoxycholic acid in the dissolution of gallstones (author's transl)].

Nine patients with radiolucent stones in the gallbladder were investigated before and during treatment with chenodeoxycholic acid (CDC). During treatment the biliary composition of bile acids changed considerably. Before the ingestion of CDC,bile acids consisted predominantly of cholic acid, deoxycholic acid and CDC; lithocholic acid was present in small amounts only. In the course of treatment CDC or this bile acid together with ursodeoxycholic acid (UDC) became the major biliary bile acid. The content of CDC increased from 47.5 +/- 4.21 to 79.2 +/- 6.37 SEM %, whereas that of UDC increased from 2.7 +/- 1.15 to 13.4 +/- 6.4%. The unsulfated lithocholic acid increased slightly from 0.7 +/- 0.22 to 2.7 +/- 0.41%. The bile acid pool expanded by an average of 130%. The degree of expansion of the pool varied considerably among the different patients. The largest increase in the pool size, however, occurred in the patients with the largest content of UDC in bile. Gallstone dissolution was observed in five patients. Among these five were those patients with the highest content of UDC, Corresponding 8.6, to 29.4 and 51.7%, respectively. These findings suggest that, in addition to CDC, UDC has a cholelitholytic effect in vivo. Of interest also was the observation that the patients in whom the size of the bile acid pool increased only very little showed no dissolution of gallstones. Both the stool weight and the fecal excretion of the isotopes, after the administration of radioactively labeled bile acids, increased only slightly during the treatment with CDC. The cholelitholytically efficacious dose of 20 mg/kg/day of CDC applied in this study appears to be useful in that 94% of it was abosrbed.

Chenodeoxycholic Acid↗
PubMed1976

[Hemoperfusion by means of encapsuled charcoal for the treatment of exogenous and endogenous intoxications].

The method developed by Chang for using in collodion and albumin encapsuled charcoal as artificial cells for hemoperfusion has been studied in vitro. The capacity for the absorption of more or less dialysable exogenous substances (barbiturate, Diazepam, Parathion) and an endogenous toxic metabolite (p-hydroxyphenyl acetic acid) has been examined. With the absorption unit one can eliminate 80 to 90 per cent of the initial concentration of barbiturate, Diazepam and p-hydroxyphenyl acetic acid in about 90 min, of Parathion about 50 per cent in the same time, whereas bromide and ammonia are not absorbed. Attempts to avoid regional heparinisation by the incorporation of heparin into the capsule of charcoal granules were not successful. Assuming correct preparation of the hemoperfusion system, observance of steril precoutions and regional heparinisation, the use of the "detoxication shunt" is a promising means in the treatment of severe exogenous and endogenous intoxications which are not accessible by conventional therapeutic means.

Adsorption↗
PubMed1976

Clinical enzymology.

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Alanine Transaminase↗