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Biomedical subjects

F W Schmidt

Publications and source records attributed to F W Schmidt.

At least 91 records · Page 5Linked to original sources
PubMed1984

[Chronic pancreatitis: sensitivity, specificity and predictive value of the pancreolauryl test].

Assessment of the clinical value of the pancreolauryl test (PLT) in the literature range from "useless" to a specifity of 95% and a sensitivity of 98%. In this work, our own data are presented in relation to various reference methods. The results are derived from the largest collective investigated to data, comprising 40 controls and 391 patients (108 with chronic pancreatitis and 283 with other gastrointestinal disorders). The specifity of the the PLT varies between 81% and 95% according to the "quality" of the control collective. The PLT is particularly frequently pathological in patients with diseases in the region of the gallbladder/bile duct and the gastrointestinal tract. The sensitivity of the PLT for chronic pancreatitis varies between 68% and 100%, depending on 9 different reference methods employed. Based on the prevalence of chronic pancreatitis with exocrine insufficiency in various patient collectives, the predictive value of the PLT for the presence of this disorder can be calculated using our data.

Cholangiopancreatography, Endoscopic Retrograde↗
PubMed1984

Whole-gut irrigation as antiendotoxinaemic therapy in inflammatory bowel disease.

Marked endotoxaemia was found in 12 patients suffering from severe relapse of chronic inflammatory bowel disease. These patients did not respond satisfactorily to conservative treatment. Whole gut irrigation was employed to reduce drastically the absorbable endotoxin pool in the gut. Following the lavage the condition of all the patients thus treated improved. Plasma endotoxins dropped rapidly, serum iron increased, and in 7 febrile patients body temperature normalized. The results obtained suggest a beneficial use of whole gut irrigation as a therapeutic means in endotoxaemia associated with inflammatory bowel disease.

Adult↗
PubMed1982

[Preprothrombin in acute viral hepatitis B].

In vitamin K deficiency or treatment with vitamin K antagonists, a precoagulant of prothrombin (Factor II) called preprothrombin has been established. We measured preprothrombin with Clarke-Freeman electrophoresis in 26 patients with acute viral hepatitis (21 HBS-AG positive) who did not suffer from vitamin K deficiency. Prothrombin and the vitamin-K dependent Factors VII, IX, and X were determined by standard coagulometric methods. Prothrombin was additionally estimated by immunoelectrophoresis according to Laurell. Three patients with acute HBS-AG positive hepatitis showed preprothrombin in their plasma. The activity of Factors II, VII, IX, and X was slightly below normal with normal concentration of Factor II in the immunoelectrophoresis. Liver parenchymal damage and cholestasis were slight; the pseudocholinesterase showed subnormal levels in all three patients. Possible causes for the appearance of preprothrombin in the peripheral blood in acute viral hepatitis and the possible connections with liver cell damage are discussed.

Acute Disease↗
PubMed1982

Intestinal lavage in the treatment of Crohn's disease: a pilot study.

Taking into account that a damaged mucosal barrier may be responsible for the impairment and some systemic complications in Crohn's disease, we employed intestinal lavage as a therapeutic method in six patients suffering from active Crohn's disease. The results were compared with those obtained from a control group that received similar treatment with the exception of the lavage. Intestinal lavage was carried out with 18 1 of normal saline administered via a jejunal tube over a period of 2 h. The lavage procedure was tolerated well by all patients. A significant decrease of the Crohn's disease activity index and a significantly lower hospitalization time suggest a benefit in using the lavage method. Provided that these results can be confirmed in a larger series of patients, intestinal lavage may contribute to the strategy of conservative treatment of Crohn's disease.

Antacids↗
PubMed1982

Effect of pancreas transplantation on liver carbohydrate metabolism in streptozotocin diabetic rats.

The failure of pancreas transplantation to normalize plasma glucagon concentration and insulin: glucagon balance in portal blood has recently been demonstrated on streptozotocin-diabetic rats. The same experimental model was used in the present study to examine the effect of pancreas transplantation on liver carbohydrate metabolism. Twenty weeks after pancreas transplantation, the left hepatic lobe was removed for studies of several glycolytic and gluconeogenic enzymes. Livers from nontransplanted diabetic rats showed decreased activities of glycolytic enzymes and enhanced activities of gluconeogenic enzymes. In recipients of pancreas transplants, however, the activities of glycolytic and gluconeogenic enzymes did not differ from those observed in normal control rats. It is concluded that the alterations of hepatic gluconeogenesis and glycolysis observed in streptozotocin-diabetic rats are restored to normal by the pancreas transplant despite its failure to obviate hyperglucagonaemia.

Animals↗
PubMed1981

[Differential diagnosis of chronic hepatitis. Active chronic hepatitis--chronic destructive cholangitis?].

Analysis of the enzyme pattern in 34 patients with liver histology indicating porto-periportal inflammation showed two statistically well differentiated groups: 20 patients with clinical suspicion of early chronic active hepatitis and 14 patients with suspected chronic destructive cholangitis. The course of the disease and the response to immunosuppressive treatment were quite different in the two groups. For differentiation of the early stages of chronic active hepatitis and chronic destructive cholangitis correct interpretation of the enzyme pattern is of great importance. It is also relevant for the decision to use long term immunosuppressive treatment.

Cholangitis↗
PubMed1980

[Immunosuppressive treatment of the early stages of active or inactive chronic hepatitis: results of a pilot study (author's transl)].

Immunosuppressive treatment with prednisolone and azathioprine was administered to a small group of nine patients in the early stage of chronic active or inactive hepatitis about six months after onset of the disease. There occurred a relatively rapid improvement in the active liver process, including biochemical and histological findings, compared with ten patients in a control group who, with the same liver condition, were not given immunosuppressive treatment. There were no side-effects in the treated group.

Azathioprine↗
PubMed1980

[Immunosuppressive treatment of chronic active hepatitis (author's transl)].

Early-stage chronic active hepatitis treated with prednisolone and azathioprine has a good prognosis. In most of the 20 patients investigated improvement occurred already after 3 months of treatment, by 6 to 9 months the laboratory findings had become normal and after 12 months there was no definite evidence histologically for the initial aggressive form of liver disease. However, in the late stage of chronic active hepatitis the effect of immunosuppressive treatment seems questionable. The tendency for improvement of laboratory findings during immunosuppression was significantly worse than in early-stage disease. Histologically there was no real improvement in two thirds of the cases a year after onset of treatment.

Azathioprine↗
PubMed1980

The Szasz-ratio (CK/GOT) as example for the diagnostic significance of enzyme ratios in serum.

The diagnostic significance of enzyme and isoenzyme ratios in serum relies on their different distribution at various levels: from organs to subcellular structures. Factors which modify the ratios are the molecular properties of enzymes and isoenzymes and their turnover in the cells and in the extracellular space. These pathophysiological principles are considered with respect to the Szasz ratio CK/GOT and its application for the differential diagnosis of acute myocardial infarction.

Aspartate Aminotransferases↗