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Biomedical subjects

F W Putnam

Publications and source records attributed to F W Putnam.

At least 163 records · Page 9Linked to original sources
PubMed1969

Macroglobulin structure: homology of mu and gamma heavy chains of human immunoglobulins.

The amino acid sequence of fragments obtained by cyanogen bromide cleavage of the mu-chain of a human gammaM-globulin is homologous to the NH(2)-terminal sequences of the gamma-chain of human and rabbit gammaG-globulins and is related to that of human light chains. This supports the hypothesis that light and heavy chains evolved from a common ancestral gene.

Amino Acid Sequence↗
PubMed1967

Evolution of immunoglobulins: structural homology of kappa and lambda Bence Jones proteins.

The amino acid sequence of a human lamba chain has been determined. There are many identities in sequence with human kappa chains, but this intraspecies homology is less than the interspecies homology of kappa light chains of man and mouse. Structural relationships suggest a common evolutionary origin and early differentiation of light- and heavy-chain genes.

Amino Acid Sequence↗
PubMed1967

Heavy chain subclasses of human gamma G-globulin. Serum distribution and cellular localization.

Two antigenic types of naturally occurring proteins related to the papain produced F(c) fragment of gammaG-globulin have been studied. Most normal and myeloma gammaG-globulins are related to one or the other of these proteins, based on antigenic and structural characteristics of their heavy chain. Molecules bearing the determinant "Cr" are approximately 10 times as abundant as those bearing the determinant termed "Zu" in pools of normal gammaG-globulin and among a large group of gammaG-myeloma globulins. Both populations have properties of typical gammaG-globulin antibodies. Splenic cells, stained for these two populations with specific fluorescent antibody preparations, are found to contain one or the other of the two populations of gammaG-globulin, but not both. Approximately 10 times as many cells contain the Cr determinant as contain the Zu determinant.

Animals↗