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Biomedical subjects

F W Lohmann

Publications and source records attributed to F W Lohmann.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Beta-receptor blockers: metabolic actions and therapeutic consequences (author's transl)].

Whereas the control of cardiac function occurs through the sympathetic nervous system via the beta 1-receptors, metabolic processes are controlled via beta 1- and/or beta 2-receptors accordingly. The inhibition occurring during the use of non-selective beta-receptor blockade of the beta 2-receptors also consequently leads undesirably to possible impairment of insulin secretion and especially to glycogenolysis in the skeletal musculature. The initially more intensely inhibited lipolysis under mixed beta-receptor blockade lead among other things to more severe changes in the lipoproteins than a predominantly beta 1-selective receptor blockade through reactive compensation procedures. Generally in the treatment of arterial hypertension, as also of cardiovascular disease with beta-receptor blocker, a beta 1-receptor blocker is preferred in order to avoid as far as possible disadvantageous metabolic actions of such treatment.

Adrenergic beta-Antagonists↗
PubMed1981

Effects of short-term and long-term treatment with cardio-selective and non-selective beta-receptor blockade on carbohydrate and lipid metabolism and on plasma catecholamines at rest and during exercise.

1. The effects on glucose and lipid metabolism and on plasma catecholamines at rest and during exercise, of 4 weeks treatment with non-selective beta-blockade (pindolol, 15 mg daily) and with cardio-selective blockade (metoprolol, 200 mg, and acebutolol, 500 mg, respectively) were compared in different groups of hypertensive men (mean age 37 years) by single blind cross-over technique. All patients continued the treatment with either metoprolol or acebutolol for another 12--14 months. 2. All antagonists reduced blood pressures and exercise heart rates in a virtually identical manner. Whereas lipolysis was similarly inhibited by both selective beta 1-antagonists and non-selective beta 1-beta 2-blockers, glycogenolysis in the muscle was inhibited only by non-selective beta-receptor blockade. 3. The inhibition of glycogen breakdown resulted in exercise hypoglycaemia and in increases of plasma adrenaline and ACTH, which probably reflect counter-regulatory mechanisms. No major metabolic changes occurred after 12--14 months compared with 4 weeks of treatment.

Acebutolol↗
PubMed1981

[Plasma catecholamines, insulin and glucose in the postoperative phase. Cause and duration of the post-stress syndrome after abdominal surgery].

Plasma catecholamine, insulin secretion, and serum glucose levels were measured to determine the extent and duration of the postaggression syndrome following major abdominal surgery: 1. There was a significant increase in plasma catecholamine levels (epinephrine and norepinephrine) during the first postoperative week. -2. Glucose dependent insulin secretion remained elevated for more than 6 days following major abdominal surgery. -3. Postoperative glucose assimilation was reduced for more than 1 week. -4. There is a negative correlation between plasma catecholamine levels and reduced insulin secretion following the administration of glucose in the postoperative phase. -5. Inhibition of insulin secretion should be included in the therapeutic considerations for the first postoperative week in all patients undergoing major abdominal surgery.

Adult↗
PubMed1979

[The influence of a combined diurectic-beta-receptorblocker therapy on elevated exercise blood pressures. Ergometric investigations in hypertensive patients (author's transl)].

In hypertensive patients physical exercise can induce considerable increases of blood pressure. This means particularly for elder patients a high risk of cardiovascular complications. Therefore we investigated in 13 elder patients suffering from arterial hypertension the effect of a hypotensive combined therapy with a diuretic and a beta-receptorblocker on elevated blood pressures during and after ergometric work. Apart from the reduction of the blood pressure at rest, especially the systolic and diastolic blood pressure during exercise was lowered significantly. In addition to a diuretic hypotensive therapy a beta-receptorblocker can be of great benefit also for elder patients particularly in order to reduce elevated exercise blood pressures.

Adrenergic beta-Antagonists↗
PubMed1979

[The influence of a long-term cardioselective and noncardioselective beta-receptorblockade on blood pressure, O2-uptake and carbohydrate metabolism. Ergometric investigations in hypertensive patients (author's transl)].

1. In 9 male hypertensives the influence of a long-term cardioselective (200 mg Metoprolol) and non-cardioselective (15 mg Pindolol) beta-receptor blockade on the blood pressure, O2-uptake and carbohydrate metabolism was investigated at rest and during a short (6 min, 100 Watt), long (30 min under steady-state conditions with a heart rate of 130/min) and maximal ergometric work and 5 min after that. 2. In this cross-over trial the blood pressure was reduced significantly (p less than 0.01) and in an identical manner by both beta-receptor blockers. 3. Though there was a significant (p less than 0.01) reduction of the heart rate of 26% by Metoprolol (M) and of 21.2% by Pindolol (P), the O2-uptake during submaximal work was unchanged under P with 1.66 +/- 0.4 l/min and under M with 1.7 +/- 0.44 l/min in comparison with the control (C) of 1.71 +/- 0.38 l/min. The maximal O2-uptake was insignificantly reduced by Pincolol (C 2.51 l/min; M 2.46 l/min; P 2.11 l/min). 4. Only under Pindolol we found in all patients a marked and insignificant (p less than 0.01) drop of the blood sugar level in the 30th min of ergometric work (C 76.2 +/- 11; M 72.6 +/- 9; P 55.3 +/- 11 mg/dl), under maximal work (C 74 +/- 12; M 73.2 +/- 10; P 54.2 +/- 11 mg/dl) and 5 min after (C 83.6 +/- 11; M 87.6 +/- 15; 69 +/- 19 mg/dl). 5. The lactic acid level showed under both beta-receptor blockers the same tendency to decrease. 6. The drop of the blood sugar to hypoglycemic values is due to an impaired glycogenolysis in the skeletal muscles and implies a considerable reduction of the physical capacity. Therefore the cardioselective beta-receptor blocker Metoprolol is recommended especially for the treatment of young hypertensives and for all patients who need their physical fitness in order to achieve their work or to perform a preventive and rehabilitative training.

Blood Glucose↗
PubMed1978

[Ergometry in the assessment of antihypertensive treatment (author's transl)].

A standardized ergometric test, suitable for recognizing abnormally high exercise blood pressures as well as the influence of hypotensive drugs on blood pressure, was employed in 13 of 28 hypertensives being treated with a combination of beta-receptor blockers (oxprenolol, 80 mg), a diuretic (chlortalidone, 10 mg), and a vasodilator (hydralazine, 25 mg). This combination was an effective antihypertensive measure with few side effects, particularly so in reducing elevated exercise blood pressures.

Adult↗