Liposclerosing myxofibrous tumor of bone.
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Bone Neoplasms↗
Biomedical subjects
F W Gilkey
Publications and source records attributed to F W Gilkey.
Epithelioid hemangioendothelioma with osteoclastlike giant cells.
This article describes histopathologic and immunohistologic features of an epithelioid hemangioendothelioma that presented in the neck of a 40-year-old man. This tumor was unusual because of the presence of osteoclastlike giant cells scattered throughout the entire lesion. The tumor cells reacted positively for factor VIII-related antigen, and the osteoclastlike giant cells were reactive for KP1 antibody, a macrophage-associated antigen. We are aware of only one other previously reported example of soft-tissue epithelioid hemangioendothelioma with an abundance of osteoclast-like giant cells.
Adult↗
Osteoid osteoma.
Osteoid osteoma is a benign skeletal neoplasm composed of osteoid and woven bone that rarely exceeds 1.5 cm in greatest dimension. The lesion is most commonly located in the cortex of long bones where it is associated with dense, fusiform, reactive sclerosis. Less often, it may be cancellous, where reactive osteosclerosis is usually less intense and may be distant from the lesion. Cancellous lesions are frequently intraarticular (most often in the hip) and may be associated with synovitis and joint effusion. Rarely, osteoid osteomas occur in a subperiosteal location. Patients are usually young, and there is a strong male predominance. Pain is the most common symptom. Radiographs of patients with cortical osteoid osteoma are often diagnostic. Intraarticular lesions, however, may be subtle, and scintigraphy may be required to locate the lesion for subsequent computed tomography (CT). CT is useful to identify and precisely locate the lesion and to provide guidance for percutaneous localization or treatment.
Adolescent↗
Osteoblastoma of the spine. A review of 75 cases.
Clinical and radiologic features of 75 cases of osteoblastoma of the spine were reviewed. In addition to pain, which was the most frequent complaint, 18 patients demonstrated objective neurologic deficit, while scoliosis was observed in 17 patients. Aspirin yielded pain relief in 13 patients. Pathologic fracture was not encountered. The radiologic and histologic characteristics of osteoblastoma of the spine are indistinguishable from those arising in other sites. The typical lesion exhibited a well-defined, geographic margin with a sclerotic, frequently lobulated border. Approximately one half of the cases were predominantly lucent, the remainder displaying varying degrees of matrix mineralization. Distribution of the osteoblastomas through the spinal axis was as follows: cervical-29, thoracic-16, lumbar-17, sacral-13. Other significant findings included posterior element involvement in 73 of 75 cases, and a striking male to female ratio of 2.5 to 1.
Adult↗
From the archives of the AFIP. Giant cell tumor of the upper extremity.
Giant cell tumor (GCT) is a relatively common primary bone tumor that typically develops in young adults between the ages of 20 and 40 years. Our archives contain 1,183 cases of histologically proved and radiographically correlated GCTs, collected in consultation over 40 years. From this large series, we identified 243 lesions (21% of GCTs) arising in the upper extremity distal to the scapula. This report demonstrates the spectrum of radiologic findings of GCT of the upper extremity, augmented where appropriate by accompanying pathologic material.
Adolescent↗
Fibrous dysplasia.
Skeletal fibrous dysplasia is a developmental anomaly in which normal bone marrow is replaced by fibroosseous tissue. This process may be localized to a single bone, or even a small segment thereof, or affect the skeleton diffusely. The radiologic archives of the Armed Forces Institute of Pathology (AFIP) contain 501 cases of histologically proved and radiographically correlated fibrous dysplasia (of which 427 cases are monostotic and 74 cases are polyostotic). We present the spectrum of radiologic findings, including those from bone scintigraphy, computed tomography, and magnetic resonance imaging, augmented where appropriate by accompanying pathologic material.
Adult↗
Primary Ewing sarcoma of rib.
Ewing sarcoma is a relatively common, highly malignant bone tumor that typically occurs in adolescents and young adults aged 10-25 years. Our archives contain 328 cases of histologically proved and radiologically correlated Ewing sarcoma collected in consultation over 40 years. From this series, we identified 34 lesions (10%) arising in ribs. Radiographically, the affected rib was predominantly lytic in most (82%) cases, but mixed lytic-sclerotic (9%) and even predominantly sclerotic (9%) patterns were also encountered. The affected rib was "expanded" in 35% of cases, although the contour change was usually mild. Abnormalities of the affected ipsilateral hemithorax varied from subtle, isolated rib involvement to solitary rib involvement accompanied by complete opacification of the hemithorax. We describe the spectrum of radiologic findings of primary Ewing sarcoma of rib, augmented where appropriate by accompanying pathologic material.
Adolescent↗
Changing MFH to FHS.
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Histiocytoma, Benign Fibrous↗
Monitoring activity of fibrinolytic agents.
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Fibrinolysis↗
A 21-year-old woman with fever and pancytopenia.
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Adult↗
MR appearance of fibroxanthoma.
Magnetic resonance images of nine patients with 10 fibroxanthomas of bone were retrospectively reviewed. Eight of 10 lesions were characterized by a markedly decreased signal of both T1- and T2-weighted pulse sequences. This pattern of decreased signal intensities, when present, proved distinctive and has not been observed in other nonossified primary bone lesions. Possible etiologies for this observation are discussed.
Bone Neoplasms↗