Biomedical subjects

F W Bauer

Publications and source records attributed to F W Bauer.

At least 37 records · Page 2Linked to original sources

PubMed1985

Methotrexate inhibits the leukotriene B4 induced intraepidermal accumulation of polymorphonuclear leukocytes.

The penetration of polymorphonuclear leukocytes (PMNs) into the epidermis following topical application of leukotriene B4 was assessed in the clinically uninvolved skin of psoriatic patients treated with methotrexate and of psoriatic patients without treatment, and in normal controls. Inhibition of PMN infiltration was observed in those patients treated with methotrexate while there was no significant difference between untreated psoriatic patients and normal controls.

Adult↗

PubMed1983

Metabolic changes at the margin of the spreading psoriatic lesion.

Keratotome slices were cut across the margins of rapidly-spreading psoriatic plaques. Each slice was divided into eight sections and in each section we measured the percentage cells in S phase and the levels of glucose-6-phosphate dehydrogenase (both related to epidermal proliferation), acid phosphatase (associated with keratinization) and alkaline phosphatase (a marker for dermal capillaries). Disturbances in the epidermis extended only 2 to 4 mm into the 'uninvolved' skin, whereas the capillaries were metabolically abnormal for a distance of about 2 cm ahead of the advancing edge of the plaque. This implies that changes in the capillary may precede those in the epidermis during the spread of the psoriatic lesion.

Acid Phosphatase↗

PubMed1983

Response of the clinically uninvolved skin of psoriatic patients to standardized injury.

Test sites on healthy controls and on the clinically uninvolved skin of psoriatic patients were stripped with tape, and eight variables were quantified at intervals during the subsequent healing process. In the control groups, the stratum corneum regenerated at a constant rate and the underlying skin showed elevations of metabolic activity peaking around days 2-4. In the psoriatic groups, we observed that (I) the response of the keratinizing zone is identical to that of the controls, (2) the proliferative response is initially normal but remains elevated rather longer than usual, and (3) the dermal capillaries (indicated by alkaline phosphatase activity) show a gross hyper-reactivity which is already apparent after 1 day and which persists for more than a week. These findings support our previous conclusion that metabolic alteration of the dermal capillary precedes epidermal hyperplasia in the pathogenesis of the psoriatic lesion.

Acid Phosphatase↗

PubMed1982

Sarcomatous transformation of nasopharyngeal angiofibroma.

A case of fibrosarcoma arising in a recurrent nasopharyngeal angiofibroma 18 years after radiation therapy is described. A review of the medical literature revealed two other documented cases of sarcomatous transformation of angiofibroma, and in both, the angiofibromas had also been irradiated before the sarcomatous transformation. These occurrences should caution against the indiscriminate application of radiation therapy in nasopharyngeal angiofibromas.

Histiocytoma, Benign Fibrous↗

PubMed1981

Flow cytometry as a tool for the study of cell kinetics in skin 2. Cell kinetic data in psoriasis.

Flow cytometry was used to measure the DNA content of epidermal keratinocytes from psoriatic patients. Gross deviations were found in the lesions and minor but significant changes in the uninvolved skin. Statistical analysis revealed that the rather large variation in the DNA distribution of the lesions was due to inter-individual differences rather than to intra-individual differences. The duration of the S-phase seemed to be prolonged in the lesion, but the length of the overall cell cycle might be of the same order as that of normal skin.

Analysis of Variance↗

PubMed1980