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Biomedical subjects

F Vrubel

Publications and source records attributed to F Vrubel.

14 recordsLinked to original sources

Carcinoma of the prostate. I. Histochemical examination as an aid in evaluating prostate carcinoma.

In 26 patients with carcinoma of the prostate (CaP) the histochemical and histological characteristics of the tumour were compared with the clinical course in both untreated patients and in those receiving hormonal therapy. In the control group 16 patients with BPH were examined in the same way. It was found that histological types of CaP cannot be identified by grading. Higher frequency of very strong LDH activity in CaP was the only distinction against BPH.

Acid Phosphatase

Carcinoma of the prostate. II. Serum activity of acid phosphatase, prostatic acid phosphatase, LDH and its isoenzymes.

In 25 patients with carcinoma of the prostate (CaP) T3 and in a comparative group of 18 patients with BPH the serum enzymes of AP, tartrate labile AP, LDH, and iso-LDH were investigated simultaneously in basal conditions and after standardized transrectal prostatic biopsy. AP, PAP as well as LDH were shown to be of small diagnostic aid. The reaction of serum enzyme levels following the standardized prostatic biopsy was the same in both CaP and BPH patients. In studying LDH-isoenzymes, we found that the third fraction was elevated in almost all patients. This change is apparently not of prostatic origin, and we could not attribute it to the concomitant diseases found in some patients.

Acid Phosphatase

Some new results of investigation of tuberous sclerosis.

The authors describe the case of a patient with tuberous sclerosis. The occurrence of M-protein with antigenous appurtenance of IgM not only in the patient himself but also in some of the healthy blood relations in the family is pointed out. The question of clinical and biochemical-immunological peculiarities occurring in connection with this disease is discussed.

Adenoma