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Biomedical subjects

F Vincent

Publications and source records attributed to F Vincent.

At least 73 records · Page 4Linked to original sources
PubMed1996

Successful treatment of severe hepatic veno-occlusive disease after allogeneic bone marrow transplantation by transjugular intrahepatic portosystemic stent-shunt (TIPS).

Severe veno-occlusive (VOD) disease is a major cause of morbidity and mortality in allogeneic bone marrow transplant recipients, and new approaches in managing patients who develop serious VOD is needed. In this report, we describe a patient who underwent transjugular intrahepatic portosystemic stent-shunt (TIPS) for life-threatening VOD are following allogeneic bone marrow transplantation for AML. Although the patient died of CMV-associated pneumonitis 5 weeks later, the TIPS functioned well until her death and permitted regression of the hepatic and renal symptoms. This report suggests that TIPS may be feasible and effective for managing patients with life-threatening liver dysfunction after marrow transplantation.

Adult↗
PubMed1996

[Survey of the use of contention shells in Centre-Rhône-Alpes area].

Contention shells are frequently used in radiotherapy. They allow improvements in the reproducibility of treatments and take part in quality assurance. The aim of our survey is to establish how centers use contention masks. Ninety-five percent of the centers questioned use contention masks. The fixation device is in most cases made of Plexiglas. The masks are always made of thermoplastics materials with low modeling temperature. They are made just before simulation or scanner by a radiographer. The surface dose problem can be overcome by two different techniques. One consists in the stretching of the material to reduce the density. The other consists of cutting out the mask where the irradiation fields are projected. Whatever the technique, there is a loss of rigidity of the mask, which means the immobilization is not so effective. Despite drawbacks, contention masks have an important role in the quality insurance in radiotherapy.

Biomechanical Phenomena↗
PubMed1996

Tumoricidal potential of human macrophages grown in vitro from blood monocytes.

Adoptive transfer of activated autologous human macrophages obtained by in vitro differentiation of monocytes in culture has successfully undergone phase I clinical trials in patients with metastatic cancer. The efficacy of these autologous macrophages in the in vivo killing of human tumors has now to be demonstrated. GM-CSF was shown to increase the number of monocytes differentiating in culture into macrophages. These were then activated with IFN gamma which was reported as the best cytokine for tumoricidal activation of macrophages. The aim of this paper was to evaluate the in vitro tumoricidal activity of macrophages grown with GM-CSF and IFN gamma. This tumoricidal function was investigated by measurement of the cytolytic (chromium-51 release assay), cytostatic (anti-proliferative activity as measured by inhibition of [3H]-thymidine incorporation in two different assays) and cytotoxic (MTT assay) activities on two tumor cells lines, U937 and K562 (respectively highly sensitive and resistant to soluble TNF alpha). Our results demonstrated that GM-CSF-grown macrophages exhibited significant cytolytic, cytotoxic and cytostatic activities on U937 cells. These were partly enhanced by IFN gamma activation. In contrast, they had no lytic and lower cytotoxic and cytostatic activities on K562 cells, and these were not modified by IFN gamma activation. Our data provide valuable information for future in vivo studies using adoptively transferred autologous macrophages.

Adoptive Transfer↗
PubMed1995

Expression of ras gene in flounder (Platichthys flesus) andred mullet (Mullus barbatus).

A member of the ras gene family was identified here for the first time in two marine fish, the flounder (Platichthys flesus) and the red mullet (Mullus barbatus). After RT-PCR the partial sequence of ras gene (exons 1 and 2) has been cloned and sequenced from normal liver. At the nucleic acid level, a very high extent of homology with the human ras genes is observed (80% to 86%) and a perfect homology is observed at the amino acid level. The high conservation of the 5' region of the ras gene suggest that the p21 protein has identical function in higher and lower vertebrates. The identification of ras gene should be a first step in understanding the molecular basis of carcinogenesis in these species.

Amino Acid Sequence↗
PubMed1995

Cerebral vasculitis after interleukin-2 therapy for renal cell carcinoma.

We report one patient with paralysis of the right upper extremity, bilateral cerebellar syndrome, and cognitive changes after treatment with interleukin-2 for metastatic renal cell carcinoma. Focal neurologic disturbances were associated with multiple images of cerebral infarcts but also with extraneurologic signs and autoantibodies. We suggest that this is a case of cerebral vasculitis with an autoimmune mechanism triggered by interleukin-2 therapy.

Adult↗