Biomedical subjects
Publications and source records attributed to F Vicente.
The estrogen receptors are analyzed in 78 breast cancer and 25 fibroadenoma samples, confirming the correlation between the amount of estrogen receptors and the tumor size, stage and number of invaded lymph nodes.
The results of the surgical treatment of human hydatic cyst by cystojejunostomy are presented. This technique was performed in 17,3% of all cysts treated by the authors. The conditions for using technique, as well as it morbidity and mortality are reviewed. The authors' conclusion is that cystojejunostomy is a valid surgical technique for hydatic cyst in some cases in which it is indicated.
Three cases of symptomatic colonic lipoma are presented. All were submucous. Clinical findings were abdominal pain, changes in intestinal rythm and rectorragia. All patients had an important loss of weight, a previously undescribed finding. Two patients had a colonic diverticulosis too. The diagnosis was made by means of radiology (barium enema) and surgery was performed in all cases with excellent results.
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A rare case of primitiv mesenchimatous neoplasm of the duodenum is presented. After a review of the few cases reported in the literature, the authors emphasize the unspecificity of the clinical features and the diagnostic reliability of the fibroendoscopy. Alterations of the cellular immunity were presented in this case. The restricted posibilities of treatment in these highly malignant tumors are also discussed.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
A review with 123 references on the analysis of 1,4-benzodiazepines in biological samples using HPLC is presented. Some important physico-chemical and biopharmacological data for the development of analytical methods are collected. Different methods of sample pretreatment, chromatographic conditions and detection systems are discussed.
The solid-phase extraction (SPE) of seven 1,4-benzodiazepines (oxazepam, diazepam, temazepam, nordazepam, brotizolam, adinazolam and midazolam) using prazepam as internal standard was investigated. The 1,4-benzodiazepines were recovered from an aqueous buffer of suitable pH, using C18 Sep-Pak cartridges and mixtures of methanol-water as elution solvent. The recovery of oxazepam using different sorbent materials (C2, C8, C18, cyanopropyl, phenyl and cyclohexyl Bond-Elut) was also examined as a function of pH and the composition of the elution solvent. The SPE of oxazepam was investigated using spiked urine samples and the C2 cartridge gave rise to the cleanest urine extracts. The recoveries of the other 1,4-benzodiazepines from spiked urine and plasma samples using the C2 cartridge was then found to be higher than 90%, without any interference from endogenous compounds of the samples. Finally, the influence of other factors such as drug concentration, sample volume and the number of times the SPE cartridge had been used was also examined.
Near-infrared reflectance spectroscopy (NIRS) was used to predict the chemical composition, apparent digestibility and digestible nutrients and energy content of commercial extruded compound foods for dogs. Fifty-six foods of known chemical composition and in vivo apparent digestibility were analysed overall and 51 foods were used to predict gross energy digestibility and digestible energy content. Modified partial least square calibration models were developed for organic matter (OM), crude protein (CP), ether extract (EE), crude fibre (CF), nitrogen free extracts (NFE) and gross energy (GE) content, the apparent digestibility (OMD, CPD, EED, NFED and GED) and the digestible nutrient and energy content (DOM, DCP, DEE, DNFE and DE) of foods. The calibration equations obtained were evaluated by the standard error and the determination coefficient of cross-validation. The cross-validation coefficients of determination (R) were 0.61, 0.99, 0.91, 0.96, 0.94 and 0.92 for OM, CP, EE, CF, NFE and GE, the corresponding standard error of cross-validation (SECV) being 5.80, 3.51, 13.35, 3.64 and 16.95 g/kg dry matter (DM) and 0.29 MJ/kg DM respectively. The prediction of apparent digestibility was slightly less accurate, but NIRS prediction of digestible nutrient (g/kg DM) and DE (MJ/kg DM) gave satisfactory results, with high R (0.93, 0.97, 0.93, 0.83 and 0.93 for DOM, DCP, DEE, DNFE and DE respectively) and relatively low SECV (11.55, 6.85, 12.14 and 22.98 g/kg DM and 0.47 MJ/kg DM). It is concluded that the precision of NIRS in predicting the energy value of compound extruded foods for dogs is similar or better than by proximate analysis, as well as being faster and more accurate.