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Biomedical subjects

F Venza

Publications and source records attributed to F Venza.

14 recordsLinked to original sources

[HIV infection and acquired immunodeficiency syndrome. III].

The present third note describes diagnostic procedures, prognosis, prophylaxis, therapy, and forensic medical problems connected with HIV infection and acquired immunodeficiency syndrome (AIDS). All these are topics of the utmost public health importance which have elicited much interest both among scientists and the general public also during the recent international conference held in Florence last June. HIV infection and the associated syndromes are extremely worrying in view of their increasing diffusion and extreme severity. In spite of the wealth of data already available, as yet we know little about this infection. Besides, all attempts at treatment and organization of prevention have proved ineffective, the latter being rendered vain by the extreme geographic spread of the disease, especially in underdeveloped countries where economic resources and individual and collective public health education are lacking. The fact of having successfully informed the medical profession about these complex problems, even though within the limits of the readers of this journal, is a source of satisfaction to us.

Acquired Immunodeficiency Syndrome

[HIV infection and the acquired immunodeficiency syndrome. II].

In this second note on AIDS, clinical aspects and epidemiology of the disease are reviewed so as to complete what has already been said in the first note which was concerned with etiology and pathogenesis. Publications that have appeared so far are reviewed not only as far as the classification of the different superinfections due to the state of immunodeficiency is concerned but also with a view to the clinical course of its various stages, i.e. the impairment of the organs involved, from the internistic point of view as well as from that of different branches of medicine, including oncology. Finally, a statistical picture of epidemiology in Italy and in different regions of the country is presented with special attention to different epidemiological patterns and to the age groups involved. The third note, to be published, will be concerned with diagnostic, therapeutic, and above all preventive measures.

Acquired Immunodeficiency Syndrome

[HIV infection and acquired immunodeficiency syndrome. I].

This is the first of three articles on AIDS, in which the story of HIV infection, its etiology and pathogenesis, its pathology and clinical features, and finally its hygienic-prophylactic measures will be reviewed in the light of our present knowledge. Although the subject has been amply illustrated by many writers, it has been deemed useful to review it in this journal in order to present readers with an account of what is known so far and what must be the subject of further rapidly evolving research.

AIDS-Related Complex

[Immune protection against rubella in a group of women in Latium].

This paper reports data concerning the immune status of 252 pregnant women with regard to rubella infection. The inverse haemagglutination was used to titrate rubella virus-antibodies and it was carried out for each pregnant woman on two blood samples, collected at three weeks' interval. Thirty-nine of the 252 pregnant women (15.50%) contracted the infection in the first trimester of pregnancy. Fifty-seven women (22.60%) showed a low degree of protection against the infection while only forty-five women had a protective rubella virus-antibody titre. Finally, 111 of the 252 (44.60%) pregnant women were rubella virus seronegative and therefore susceptible to the infection.

Adolescent

[The food poisoning problem in communal restaurant facilities].

In view of the considerable development during the last few years of communal feeding facilities (factory, school, and university canteens, hospital kitchens, self service, fast food, and restaurants) in our country as well as elsewhere, the authors wish to supply detailed information on the incidence of food poisoning in Italy from 1979 to 1988 in such facilities. They report the findings of an epidemiological study they carried out in Rome and Lazio [correction of Latium] covering this period and which by and large confirmed the trend observed at the national level. As to prevention, the most recent techniques for food conservation are described.

Bacterial Infections

[Legionellosis].

In the above review, the authors intended to stress the epidemiologic importance of legionellosis which has become a frequent cause of respiratory pathology in the short time since its first appearance (1976), reaching a for from negligible proportion among respiratory disorders (2-8% of acute bronchopulmonary diseases) and a considerable death rate (10-40%). Clinical and diagnostic as well as therapeutic aspects and especially prophylaxis all discussed, the latter concerning above all the environment and adequate maintenance of heating and air-conditioning equipment in community centers, and particularly in hospitals and hotels.

Adult

[Up-date on the epidemiology of rheumatic diseases].

The present study is an up-date on rheumatic fever for the last ten years. The disease has erroneously been considered to have largely or completely disappeared whereas epidemiological data show it to be still prevalent especially in the developing countries. However, in the industrialized countries, too, its prevalence is by no means negligible; e.g. in the US the last ten years have witnessed an alarming recrudescence involving vast strata of the population and especially children, although this is masked by the paucity of reports, as is the case also in Italy. Chemoprophylaxis is then discussed. This is highly successful, especially if applied at an early stage, and finally therapy is described in great detail.

Adolescent

[Brucellosis].

Brucellosis is as yet an unsolved problem in view of its persistent occurrence in spite of government-sponsored prophylactic campaigns in animals. Environmental, social, economic and behavioral factors prevent the eradication of brucellosis from our country. The authors report epidemiological data of animal and human brucellosis during the last ten years, and stress the need for the vaccination of animals, hoping for an increased sensitivity among breeders and for a more efficient and consequent control by the responsible health authorities, as well as for appropriate and comprehensive control of foodstuffs, above all of milk and milk products.

Adolescent

[Ancylostomiasis].

Ancylostomiasis, i.e., infestation by Ancylostoma duodenale or Necator americanus, involves several thousands of subjects every year throughout the world and especially in tropical and subtropical regions where it is endemic. In Italy, after a severe epidemic during the construction of the St. Gotthard tunnel in the 1880s, and after a period of endemic infestation limited to some areas (1955-60), the last few years have witnessed a marked drop in the incidence of this disease which is nevertheless relevant in that it involves certain groups with occupational risk (farmers, miners, workers in clay quarries, etc.) and certain geographic areas of our country where inadequate hygienic behavior still persists among the rural population. After up-dating the epidemiology of the infestation, the authors review the principal prophylactic and therapeutic measures available.

Adolescent

[Acute respiratory virosis].

The authors discuss acute viral infections of the respiratory tract that cause high epidemic-pandemic morbidity and relevant mortality owing to secondary bacterial superinfections. Current measures of environmental and individual prevention do not seem to be effective. Similarly, the traditional therapeutic approach based on antibiotics is not always sufficient. However, the yearly prophylactic vaccination against influenza virus is the effective measure provided current WHO recommendations are followed.

Acute Disease

Chemotherapeutic agents with an imidazole moiety. III. Synthesis and microbiological activity of new 1,4-diarylimidazole and 1,4-pyrrolimidazolphenylene derivatives.

New 1,4-diarylimidazole and 1,4-pyrrolimidazol-phenylene derivatives were prepared in attempt to deepen S.A.R. study on chemotherapeutic agents with an imidazole moiety. Antimicrobial data in comparison with antifungal antibiotic pyrrolnitrin showed that all tested compounds are practically inactive against blastomycetes but some derivatives exhibited selective activity against strains of gram-negative bacteria. The results obtained are discussed on the basis of structure-activity relationships.

Anti-Bacterial Agents

[Anthrax].

Having dwelled on the etiopathogenetic, pathologic, and clinical features of human infections caused by B. anthracis, the authors review and analyze epidemiological data of the cases of anthrax registered in Italy during the last ten years. Actual possibilities for prevention are evaluated in view of the fact that enzootic foci still exist in our country which are clearly responsible for the typically occupational occurrence of this type of infection in certain at-risk categories (farmers, husbandmen, butchers, veterinarians, but also workers in those branches of industry which use materials of animal origin, such as wool, leather, bristles, fur, etc.).

Animals