Biomedical subjects

F Vella

Publications and source records attributed to F Vella.

At least 37 records · Page 2Linked to original sources

PubMed1975

Some physicochemical properties of hemoglobin-manitoba (alpha2 102Ser replaced by Arg (G9) beta2).

Hb-Manitoba was discovered in 1970 [1] in a Canadian family of British origin. Recently we observed the same variant in a second family, and found that the oxy-derivative of Hb-Manitoba is slightly unstable at 65 degrees C, dissociates less readily at alkaline pH than does Hb-A, and forms asymmetric hybrids with other hemoglobins which are readily detectable by electrophoresis.

Adult↗

PubMed1975

Haemoglobin G Norfolk: alpha 85 (F6) Asp leads to Asn.

The characterisation of haemoglobin G Norfolk (alpha2 85 Asp leads to Asn 2) is described. This variant has been identified in the heterozygous state in three apparently unrelated English families of which two are resident in England and the other in Canada.

Amino Acids↗

PubMed1975

The human hemoglobin variants in Canada.

This report summarizes the results of a search for abnormal hemoglobin variants by use of a filter paper electrophoresis technique on 228,300 blood samples obtained from various parts of four Canadian provinces. Abnormal variants were found in 438 samples and were of 27 different varieties, including six new ones. In addition, the characteristics of beta-thalassemia were found in 147 samples. The types of variant found, and their geographical and ethnic origin are presented.

Alberta↗

PubMed1975

Mechanical stability of human haemoglobins.

The mechanical stability of oxyhaemoglobins A, Agenogi, C, E, F, J Toronto, Little Rock, Riverdale-Bronx, San Diego, Stanleyville-2, and Tak was found to be similar, that of A2, Duarte and D Punjab was slightly subnormal, and of Bucuresti, H, Köln, M Saskatoon, S, Shepherds Bush and Zürich was markedly decreased. Cyanide increased the stability of the latter haemoglobins.

Cyanides↗

PubMed1974